5GIO

Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0030515	molecular_function	snoRNA binding
A	0031428	cellular_component	box C/D methylation guide snoRNP complex
A	0032040	cellular_component	small-subunit processome
B	0005515	molecular_function	protein binding
B	0030515	molecular_function	snoRNA binding
B	0031428	cellular_component	box C/D methylation guide snoRNP complex
B	0032040	cellular_component	small-subunit processome
C	0001682	biological_process	tRNA 5'-leader removal
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0004526	molecular_function	ribonuclease P activity
C	0005737	cellular_component	cytoplasm
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0008033	biological_process	tRNA processing
C	0019843	molecular_function	rRNA binding
C	0042254	biological_process	ribosome biogenesis
C	1990904	cellular_component	ribonucleoprotein complex
D	0001682	biological_process	tRNA 5'-leader removal
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0004526	molecular_function	ribonuclease P activity
D	0005737	cellular_component	cytoplasm
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0008033	biological_process	tRNA processing
D	0019843	molecular_function	rRNA binding
D	0042254	biological_process	ribosome biogenesis
D	1990904	cellular_component	ribonucleoprotein complex
E	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0006338	biological_process	chromatin remodeling
E	0006364	biological_process	rRNA processing
E	0008033	biological_process	tRNA processing
E	0008168	molecular_function	methyltransferase activity
E	0008649	molecular_function	rRNA methyltransferase activity
E	0016740	molecular_function	transferase activity
E	0031167	biological_process	rRNA methylation
E	0031428	cellular_component	box C/D methylation guide snoRNP complex
E	0032259	biological_process	methylation
E	1990259	molecular_function	histone H2AQ104 methyltransferase activity
F	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0006338	biological_process	chromatin remodeling
F	0006364	biological_process	rRNA processing
F	0008033	biological_process	tRNA processing
F	0008168	molecular_function	methyltransferase activity
F	0008649	molecular_function	rRNA methyltransferase activity
F	0016740	molecular_function	transferase activity
F	0031167	biological_process	rRNA methylation
F	0031428	cellular_component	box C/D methylation guide snoRNP complex
F	0032259	biological_process	methylation
F	1990259	molecular_function	histone H2AQ104 methyltransferase activity
K	0005515	molecular_function	protein binding
K	0030515	molecular_function	snoRNA binding
K	0031428	cellular_component	box C/D methylation guide snoRNP complex
K	0032040	cellular_component	small-subunit processome
L	0001682	biological_process	tRNA 5'-leader removal
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0004526	molecular_function	ribonuclease P activity
L	0005737	cellular_component	cytoplasm
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0008033	biological_process	tRNA processing
L	0019843	molecular_function	rRNA binding
L	0042254	biological_process	ribosome biogenesis
L	1990904	cellular_component	ribonucleoprotein complex
M	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0006338	biological_process	chromatin remodeling
M	0006364	biological_process	rRNA processing
M	0008033	biological_process	tRNA processing
M	0008168	molecular_function	methyltransferase activity
M	0008649	molecular_function	rRNA methyltransferase activity
M	0016740	molecular_function	transferase activity
M	0031167	biological_process	rRNA methylation
M	0031428	cellular_component	box C/D methylation guide snoRNP complex
M	0032259	biological_process	methylation
M	1990259	molecular_function	histone H2AQ104 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue SAH E 301

Chain	Residue
E	TYR82
E	ASP133
E	ALA134
E	ASP153
E	ALA155
E	GLN156
G	U25
E	GLY84
E	ALA86
E	THR89
E	THR90
E	GLU108
E	PHE109
E	SER110
E	ALA132

---

site_id	AC2
Number of Residues	16
Details	binding site for residue SAH F 301

Chain	Residue
F	TYR82
F	GLY84
F	ALA86
F	THR90
F	GLU108
F	PHE109
F	SER110
F	ASP133
F	ALA134
F	ASP153
F	ILE154
F	ALA155
F	GLN156
H	U25
J	U4
J	G5

---

site_id	AC3
Number of Residues	12
Details	binding site for residue SAH M 301

Chain	Residue
M	LYS60
M	TYR82
M	GLY84
M	THR90
M	GLU108
M	PHE109
M	ASP133
M	ALA134
M	ASP153
M	ILE154
M	ALA155
M	GLN156

---

Functional Information from PROSITE/UniProt

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CdekkIPYvyVsSKkaLG

Chain	Residue	Details
C	CYS73-GLY90

---

site_id	PS00566
Number of Residues	15
Details	FIBRILLARIN Fibrillarin signature. GKAYGVEFSpRvvRE

Chain	Residue	Details
E	GLY102-GLU116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
E	THR89
E	GLU108
E	ASP133
E	ASP153
F	THR89
F	GLU108
F	ASP133
F	ASP153
M	THR89
M	GLU108
M	ASP133
M	ASP153

---