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5GIB

Succinic acid bound trypsin crystallized as dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007586biological_processdigestion
A0008236molecular_functionserine-type peptidase activity
A0046872molecular_functionmetal ion binding
A0097180cellular_componentserine protease inhibitor complex
A0097655molecular_functionserpin family protein binding
B0004175molecular_functionendopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0007586biological_processdigestion
B0008236molecular_functionserine-type peptidase activity
B0046872molecular_functionmetal ion binding
B0097180cellular_componentserine protease inhibitor complex
B0097655molecular_functionserpin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue SIN A 301
ChainResidue
APHE24
AHIS40
ACYS109
ATYR131
AGLN174
AGLY175
ASER177
ALYS208

site_idAC2
Number of Residues4
Detailsbinding site for residue CA A 302
ChainResidue
AASN54
AVAL57
AGLU62
AGLU52

site_idAC3
Number of Residues5
Detailsbinding site for residue CA B 301
ChainResidue
BGLU52
BASN54
BVAL57
BGLU59
BGLU62

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
AVAL36-CYS41

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV
ChainResidueDetails
AASP171-VAL182

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS40
AASP84
ASER177
BHIS40
BASP84
BSER177

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING:
ChainResidueDetails
AGLU52
BVAL57
BGLU62
BASP171
BGLN174
BSER177
AASN54
AVAL57
AGLU62
AASP171
AGLN174
ASER177
BGLU52
BASN54

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PDB entries from 2024-10-16

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