5GAP

Body region of the U4/U6.U5 tri-snRNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
A	0000386	molecular_function	second spliceosomal transesterification activity
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000389	biological_process	mRNA 3'-splice site recognition
A	0000395	biological_process	mRNA 5'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003724	molecular_function	RNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0042802	molecular_function	identical protein binding
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0000244	biological_process	spliceosomal tri-snRNP complex assembly
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003674	molecular_function	molecular_function
F	0003723	molecular_function	RNA binding
F	0005634	cellular_component	nucleus
F	0005681	cellular_component	spliceosomal complex
F	0005687	cellular_component	U4 snRNP
F	0005739	cellular_component	mitochondrion
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071001	cellular_component	U4/U6 snRNP
F	0071011	cellular_component	precatalytic spliceosome
F	0097526	cellular_component	spliceosomal tri-snRNP complex
G	0000245	biological_process	spliceosomal complex assembly
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003674	molecular_function	molecular_function
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005681	cellular_component	spliceosomal complex
G	0005687	cellular_component	U4 snRNP
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0071001	cellular_component	U4/U6 snRNP
H	0000245	biological_process	spliceosomal complex assembly
H	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003674	molecular_function	molecular_function
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005681	cellular_component	spliceosomal complex
H	0005687	cellular_component	U4 snRNP
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0017070	molecular_function	U6 snRNA binding
H	0030621	molecular_function	U4 snRNA binding
H	0034247	biological_process	snoRNA splicing
H	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
H	0071001	cellular_component	U4/U6 snRNP
J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0005682	cellular_component	U5 snRNP
J	0006396	biological_process	RNA processing
J	0006397	biological_process	mRNA processing
J	0008150	biological_process	biological_process
J	0008380	biological_process	RNA splicing
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0071001	cellular_component	U4/U6 snRNP
J	0071013	cellular_component	catalytic step 2 spliceosome
K	0000245	biological_process	spliceosomal complex assembly
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000452	biological_process	snoRNA guided rRNA 2'-O-methylation
K	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0005687	cellular_component	U4 snRNP
K	0005730	cellular_component	nucleolus
K	0006364	biological_process	rRNA processing
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0030490	biological_process	maturation of SSU-rRNA
K	0030621	molecular_function	U4 snRNA binding
K	0031428	cellular_component	box C/D methylation guide snoRNP complex
K	0032040	cellular_component	small-subunit processome
K	0034511	molecular_function	U3 snoRNA binding
K	0042254	biological_process	ribosome biogenesis
K	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
K	0071001	cellular_component	U4/U6 snRNP
K	0071011	cellular_component	precatalytic spliceosome
K	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. GINIDSLKFNELVKLM

Chain	Residue	Details
B	GLY174-MET189

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IGSAshDmTWRLWDA

Chain	Residue	Details
H	ILE280-ALA294
H	VAL322-ILE336
H	VAL364-ILE378

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site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVpSRvaLG

Chain	Residue	Details
K	CYS71-GLY88

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
B	ALA521
B	SER1370

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
B	SER403

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