Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5GAM

Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0005681	cellular_component	spliceosomal complex
C	0000166	molecular_function	nucleotide binding
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000974	cellular_component	Prp19 complex
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0000243	cellular_component	commitment complex
b	0000245	biological_process	spliceosomal complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000395	biological_process	mRNA 5'-splice site recognition
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0000974	cellular_component	Prp19 complex
b	0003674	molecular_function	molecular_function
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0032991	cellular_component	protein-containing complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0070990	molecular_function	snRNP binding
b	0071001	cellular_component	U4/U6 snRNP
b	0071004	cellular_component	U2-type prespliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990904	cellular_component	ribonucleoprotein complex
d	0000243	cellular_component	commitment complex
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000395	biological_process	mRNA 5'-splice site recognition
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0000974	cellular_component	Prp19 complex
d	0003723	molecular_function	RNA binding
d	0003729	molecular_function	mRNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006396	biological_process	RNA processing
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071001	cellular_component	U4/U6 snRNP
d	0071004	cellular_component	U2-type prespliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
d	1990904	cellular_component	ribonucleoprotein complex
e	0000243	cellular_component	commitment complex
e	0000245	biological_process	spliceosomal complex assembly
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000395	biological_process	mRNA 5'-splice site recognition
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005737	cellular_component	cytoplasm
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0032991	cellular_component	protein-containing complex
e	0034715	cellular_component	pICln-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071001	cellular_component	U4/U6 snRNP
e	0071004	cellular_component	U2-type prespliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
e	1990935	molecular_function	splicing factor binding
f	0000243	cellular_component	commitment complex
f	0000245	biological_process	spliceosomal complex assembly
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000395	biological_process	mRNA 5'-splice site recognition
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0000974	cellular_component	Prp19 complex
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005737	cellular_component	cytoplasm
f	0006397	biological_process	mRNA processing
f	0008266	molecular_function	poly(U) RNA binding
f	0008380	biological_process	RNA splicing
f	0034715	cellular_component	pICln-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071001	cellular_component	U4/U6 snRNP
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0120114	cellular_component	Sm-like protein family complex
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
f	1990935	molecular_function	splicing factor binding
g	0000243	cellular_component	commitment complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000395	biological_process	mRNA 5'-splice site recognition
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003674	molecular_function	molecular_function
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005737	cellular_component	cytoplasm
g	0006397	biological_process	mRNA processing
g	0008150	biological_process	biological_process
g	0008380	biological_process	RNA splicing
g	0032991	cellular_component	protein-containing complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071001	cellular_component	U4/U6 snRNP
g	0071004	cellular_component	U2-type prespliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
h	0000243	cellular_component	commitment complex
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000395	biological_process	mRNA 5'-splice site recognition
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0000974	cellular_component	Prp19 complex
h	0003723	molecular_function	RNA binding
h	0003729	molecular_function	mRNA binding
h	0005634	cellular_component	nucleus
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0071001	cellular_component	U4/U6 snRNP
h	0071004	cellular_component	U2-type prespliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0097525	cellular_component	spliceosomal snRNP complex
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
j	0000243	cellular_component	commitment complex
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000395	biological_process	mRNA 5'-splice site recognition
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0000974	cellular_component	Prp19 complex
j	0003674	molecular_function	molecular_function
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008150	biological_process	biological_process
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034715	cellular_component	pICln-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071001	cellular_component	U4/U6 snRNP
j	0071004	cellular_component	U2-type prespliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue GTP C 1101

Chain	Residue
C	LEU142
C	GLY217
C	LYS269
C	SER315
C	THR316
C	LYS317
C	HIS143
C	GLY145
C	LYS146
C	THR147
C	SER148
C	LEU189
C	SER190
C	ALA215

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	207
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	72
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)