5G5S
Structure of the Argonaute protein from Methanocaldcoccus janaschii
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0044355 | biological_process | clearance of foreign intracellular DNA |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1714 |
| Chain | Residue |
| A | ALA289 |
| A | LEU292 |
| A | ILE295 |
| A | ASN297 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE TRS A 1715 |
| Chain | Residue |
| A | ARG529 |
| A | ARG530 |
| A | LYS706 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q746M7 |
| Chain | Residue | Details |
| A | ASP504 | |
| A | GLU541 | |
| A | ASP570 | |
| A | ASP688 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5G5T |
| Chain | Residue | Details |
| A | GLN457 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:28319084 |
| Chain | Residue | Details |
| A | GLN479 | |
| A | LYS483 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q746M7 |
| Chain | Residue | Details |
| A | ASP504 | |
| A | ASP570 | |
| A | ASP688 | |
| A | ILE713 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | SITE: Interacts with gDNA => ECO:0000269|PubMed:28319084, ECO:0007744|PDB:5G5T |
| Chain | Residue | Details |
| A | LYS107 | |
| A | HIS157 | |
| A | LYS191 | |
| A | TYR217 | |
| A | GLN479 | |
| A | SER669 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Interacts with 3'-end of gDNA => ECO:0000269|PubMed:28319084, ECO:0007744|PDB:5G5T |
| Chain | Residue | Details |
| A | TYR194 |
