5G5A
Glutathione transferase U25 from Arabidopsis thaliana in complex with glutathione disulfide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0009407 | biological_process | toxin catabolic process |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0009407 | biological_process | toxin catabolic process |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
| C | 0004364 | molecular_function | glutathione transferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0009407 | biological_process | toxin catabolic process |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0016740 | molecular_function | transferase activity |
| C | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
| D | 0004364 | molecular_function | glutathione transferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0009407 | biological_process | toxin catabolic process |
| D | 0009636 | biological_process | response to toxic substance |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | Binding site for residues GSH A1221 and GSH A1222 |
| Chain | Residue |
| A | SER13 |
| A | ARG111 |
| A | HOH2010 |
| A | HOH2064 |
| A | HOH2071 |
| A | HOH2111 |
| A | HOH2189 |
| A | HOH2190 |
| A | PHE15 |
| A | LYS40 |
| A | LYS53 |
| A | ILE54 |
| A | PRO55 |
| A | GLU66 |
| A | SER67 |
| A | TYR107 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | Binding site for residues GSH B1221 and GSH B1222 |
| Chain | Residue |
| B | SER13 |
| B | PHE15 |
| B | LYS40 |
| B | LYS53 |
| B | ILE54 |
| B | PRO55 |
| B | GLU66 |
| B | SER67 |
| B | TYR107 |
| B | ARG111 |
| B | HOH2088 |
| B | HOH2096 |
| B | HOH2129 |
| B | HOH2204 |
| B | HOH2205 |
| B | HOH2206 |
| B | HOH2207 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | Binding site for residues GSH C1221 and GSH C1222 |
| Chain | Residue |
| C | SER13 |
| C | PHE15 |
| C | LYS40 |
| C | LYS53 |
| C | ILE54 |
| C | PRO55 |
| C | GLU66 |
| C | SER67 |
| C | TYR107 |
| C | ARG111 |
| C | HOH2012 |
| C | HOH2057 |
| C | HOH2105 |
| C | HOH2168 |
| C | HOH2169 |
| C | HOH2170 |
| D | LYS104 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | Binding site for residues GSH D1221 and GSH D1222 |
| Chain | Residue |
| C | LYS104 |
| C | HOH2108 |
| D | SER13 |
| D | PHE15 |
| D | LEU37 |
| D | LYS40 |
| D | LYS53 |
| D | ILE54 |
| D | PRO55 |
| D | GLU66 |
| D | SER67 |
| D | TYR107 |
| D | ARG111 |
| D | HOH2027 |
| D | HOH2043 |
| D | HOH2047 |
| D | HOH2149 |
| D | HOH2150 |
| D | HOH2151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER13 | |
| C | ASN39 | |
| C | LYS53 | |
| C | GLU66 | |
| D | SER13 | |
| D | ASN39 | |
| D | LYS53 | |
| D | GLU66 | |
| A | ASN39 | |
| A | LYS53 | |
| A | GLU66 | |
| B | SER13 | |
| B | ASN39 | |
| B | LYS53 | |
| B | GLU66 | |
| C | SER13 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ZW27 |
| Chain | Residue | Details |
| A | THR149 | |
| B | THR149 | |
| C | THR149 | |
| D | THR149 |
