5G4P

Crystal structure of human hippocalcin at 2.4 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0019722	biological_process	calcium-mediated signaling
A	0019900	molecular_function	kinase binding
A	0030424	cellular_component	axon
A	0032590	cellular_component	dendrite membrane
A	0032809	cellular_component	neuronal cell body membrane
A	0032839	cellular_component	dendrite cytoplasm
A	0042802	molecular_function	identical protein binding
A	0043204	cellular_component	perikaryon
A	0044327	cellular_component	dendritic spine head
A	0046872	molecular_function	metal ion binding
A	0048839	biological_process	inner ear development
A	0060041	biological_process	retina development in camera-type eye
A	0071257	biological_process	cellular response to electrical stimulus
A	0071277	biological_process	cellular response to calcium ion
A	0090314	biological_process	positive regulation of protein targeting to membrane
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099149	biological_process	regulation of postsynaptic neurotransmitter receptor internalization
A	1901385	biological_process	regulation of voltage-gated calcium channel activity
A	1901986	biological_process	response to ketamine
A	1902065	biological_process	response to L-glutamate
A	1904010	biological_process	response to Aroclor 1254
A	1905232	biological_process	cellular response to L-glutamate
E	0003779	molecular_function	actin binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009966	biological_process	regulation of signal transduction
E	0016020	cellular_component	membrane
E	0019722	biological_process	calcium-mediated signaling
E	0019900	molecular_function	kinase binding
E	0030424	cellular_component	axon
E	0032590	cellular_component	dendrite membrane
E	0032809	cellular_component	neuronal cell body membrane
E	0032839	cellular_component	dendrite cytoplasm
E	0042802	molecular_function	identical protein binding
E	0043204	cellular_component	perikaryon
E	0044327	cellular_component	dendritic spine head
E	0046872	molecular_function	metal ion binding
E	0048839	biological_process	inner ear development
E	0060041	biological_process	retina development in camera-type eye
E	0071257	biological_process	cellular response to electrical stimulus
E	0071277	biological_process	cellular response to calcium ion
E	0090314	biological_process	positive regulation of protein targeting to membrane
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099149	biological_process	regulation of postsynaptic neurotransmitter receptor internalization
E	1901385	biological_process	regulation of voltage-gated calcium channel activity
E	1901986	biological_process	response to ketamine
E	1902065	biological_process	response to L-glutamate
E	1904010	biological_process	response to Aroclor 1254
E	1905232	biological_process	cellular response to L-glutamate

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 201

Chain	Residue
A	ASP73
A	ASN75
A	ASP77
A	THR79
A	GLU84
A	HOH301

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 202

Chain	Residue
A	LYS163
A	GLU168
A	ASP157
A	ASN159
A	ASP161

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 203

Chain	Residue
A	ASP109
A	ASP111
A	ASN113
A	TYR115
A	GLU120

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CA E 201

Chain	Residue
E	ASP73
E	ASN75
E	ASP77
E	THR79
E	GLU84

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA E 202

Chain	Residue
E	ASP157
E	ASN159
E	ASP161
E	LYS163
E	GLU168

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CA E 203

Chain	Residue
E	ASP109
E	ASP111
E	ASN113
E	TYR115
E	GLU120

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DTNSDGTIDfrEF

Chain	Residue	Details
A	ASP73-PHE85
A	ASP109-MET121
A	ASP157-PHE169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	70
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28398555","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5G58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5M6C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---