5G3J
Discovery of New Selective Glucocorticoid Receptor Agonist Leads
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CPS A 1777 |
| Chain | Residue |
| A | TRP610 |
| A | ASP638 |
| A | ASP641 |
| A | TYR660 |
| A | TYR735 |
| A | MET745 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1778 |
| Chain | Residue |
| A | HOH2020 |
| A | HOH2021 |
| A | PRO541 |
| A | TRP577 |
| A | LYS667 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE E7T A 1779 |
| Chain | Residue |
| A | MET560 |
| A | LEU563 |
| A | ASN564 |
| A | GLN570 |
| A | TRP600 |
| A | MET601 |
| A | MET604 |
| A | ARG611 |
| A | PHE623 |
| A | GLN642 |
| A | MET646 |
| A | THR739 |
| A | PHE749 |
| A | LEU753 |
| A | HOH2033 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 165 |
| Details | Region: {"description":"Interaction with CRY1","evidences":[{"source":"PubMed","id":"22170608","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"12144530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"LXXLL motif 3"} |
| Chain | Residue | Details |
