5G2E

Structure of the Nap1 H2A H2B complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006334	biological_process	nucleosome assembly
B	0005634	cellular_component	nucleus
B	0006334	biological_process	nucleosome assembly
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0005634	cellular_component	nucleus
E	0006334	biological_process	nucleosome assembly
F	0005634	cellular_component	nucleus
F	0006334	biological_process	nucleosome assembly
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
I	0005634	cellular_component	nucleus
I	0006334	biological_process	nucleosome assembly
J	0005634	cellular_component	nucleus
J	0006334	biological_process	nucleosome assembly
K	0000786	cellular_component	nucleosome
K	0003677	molecular_function	DNA binding
K	0030527	molecular_function	structural constituent of chromatin
K	0046982	molecular_function	protein heterodimerization activity
L	0000786	cellular_component	nucleosome
L	0003677	molecular_function	DNA binding
L	0030527	molecular_function	structural constituent of chromatin
L	0046982	molecular_function	protein heterodimerization activity
M	0005634	cellular_component	nucleus
M	0006334	biological_process	nucleosome assembly
N	0005634	cellular_component	nucleus
N	0006334	biological_process	nucleosome assembly
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0030527	molecular_function	structural constituent of chromatin
O	0046982	molecular_function	protein heterodimerization activity
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
P	0030527	molecular_function	structural constituent of chromatin
P	0046982	molecular_function	protein heterodimerization activity
Q	0005634	cellular_component	nucleus
Q	0006334	biological_process	nucleosome assembly
R	0005634	cellular_component	nucleus
R	0006334	biological_process	nucleosome assembly
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0030527	molecular_function	structural constituent of chromatin
S	0046982	molecular_function	protein heterodimerization activity
T	0000786	cellular_component	nucleosome
T	0003677	molecular_function	DNA binding
T	0030527	molecular_function	structural constituent of chromatin
T	0046982	molecular_function	protein heterodimerization activity
U	0005634	cellular_component	nucleus
U	0006334	biological_process	nucleosome assembly
V	0005634	cellular_component	nucleus
V	0006334	biological_process	nucleosome assembly
W	0000786	cellular_component	nucleosome
W	0003677	molecular_function	DNA binding
W	0030527	molecular_function	structural constituent of chromatin
W	0046982	molecular_function	protein heterodimerization activity
X	0000786	cellular_component	nucleosome
X	0003677	molecular_function	DNA binding
X	0030527	molecular_function	structural constituent of chromatin
X	0046982	molecular_function	protein heterodimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

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site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
D	SER109
R	LEU330-ALA356
U	LEU330-ALA356
V	LEU330-ALA356
H	SER109
L	SER109
P	SER109
T	SER109
X	SER109
M	LEU330-ALA356
N	LEU330-ALA356
Q	LEU330-ALA356

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site_id	SWS_FT_FI2
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0C1H4

Chain	Residue	Details
D	LYS117
S	LYS75
X	LYS117
W	LYS75
C	LYS75
H	LYS117
G	LYS75
L	LYS117
K	LYS75
P	LYS117
O	LYS75
T	LYS117

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site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS95
R	SER82
U	SER82
V	SER82
G	LYS95
K	LYS95
O	LYS95
S	LYS95
W	LYS95
M	SER82
N	SER82
Q	SER82

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N5-methylglutamine => ECO:0000250

Chain	Residue	Details
C	GLN104
I	SER104
J	SER98
J	SER104
M	SER98
M	SER104
N	SER98
N	SER104
Q	SER98
Q	SER104
R	SER98
G	GLN104
R	SER104
U	SER98
U	SER104
V	SER98
V	SER104
K	GLN104
O	GLN104
S	GLN104
W	GLN104
F	SER98
F	SER104
I	SER98

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS118
R	SER140
U	SER140
V	SER140
G	LYS118
K	LYS118
O	LYS118
S	LYS118
W	LYS118
M	SER140
N	SER140
Q	SER140

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
C	LYS13
O	LYS13
U	SER159
O	LYS15
S	LYS13
S	LYS15
W	LYS13
W	LYS15
B	SER159
C	LYS15
G	LYS13
I	SER159
G	LYS15
K	LYS13
N	SER159
K	LYS15

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site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:18086883, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER177
R	SER177
U	SER177
V	SER177
B	SER177
E	SER177
F	SER177
I	SER177
J	SER177
M	SER177
N	SER177
Q	SER177

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