Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5G1S

Open conformation of Francisella tularensis ClpP at 1.7 A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0016787	molecular_function	hydrolase activity
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0016787	molecular_function	hydrolase activity
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0016787	molecular_function	hydrolase activity
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0016787	molecular_function	hydrolase activity
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0016787	molecular_function	hydrolase activity
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0016787	molecular_function	hydrolase activity
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0016787	molecular_function	hydrolase activity
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0016787	molecular_function	hydrolase activity
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0016787	molecular_function	hydrolase activity
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0016787	molecular_function	hydrolase activity
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0016787	molecular_function	hydrolase activity
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0016787	molecular_function	hydrolase activity
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0016787	molecular_function	hydrolase activity
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0016787	molecular_function	hydrolase activity
N	0051117	molecular_function	ATPase binding
O	0004176	molecular_function	ATP-dependent peptidase activity
O	0004252	molecular_function	serine-type endopeptidase activity
O	0005737	cellular_component	cytoplasm
O	0006508	biological_process	proteolysis
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0008233	molecular_function	peptidase activity
O	0008236	molecular_function	serine-type peptidase activity
O	0009368	cellular_component	endopeptidase Clp complex
O	0016787	molecular_function	hydrolase activity
O	0051117	molecular_function	ATPase binding
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005737	cellular_component	cytoplasm
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0008233	molecular_function	peptidase activity
P	0008236	molecular_function	serine-type peptidase activity
P	0009368	cellular_component	endopeptidase Clp complex
P	0016787	molecular_function	hydrolase activity
P	0051117	molecular_function	ATPase binding
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005737	cellular_component	cytoplasm
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0008233	molecular_function	peptidase activity
Q	0008236	molecular_function	serine-type peptidase activity
Q	0009368	cellular_component	endopeptidase Clp complex
Q	0016787	molecular_function	hydrolase activity
Q	0051117	molecular_function	ATPase binding
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005737	cellular_component	cytoplasm
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0008233	molecular_function	peptidase activity
R	0008236	molecular_function	serine-type peptidase activity
R	0009368	cellular_component	endopeptidase Clp complex
R	0016787	molecular_function	hydrolase activity
R	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005737	cellular_component	cytoplasm
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0008233	molecular_function	peptidase activity
S	0008236	molecular_function	serine-type peptidase activity
S	0009368	cellular_component	endopeptidase Clp complex
S	0016787	molecular_function	hydrolase activity
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005737	cellular_component	cytoplasm
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008233	molecular_function	peptidase activity
T	0008236	molecular_function	serine-type peptidase activity
T	0009368	cellular_component	endopeptidase Clp complex
T	0016787	molecular_function	hydrolase activity
T	0051117	molecular_function	ATPase binding
U	0004176	molecular_function	ATP-dependent peptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005737	cellular_component	cytoplasm
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0008233	molecular_function	peptidase activity
U	0008236	molecular_function	serine-type peptidase activity
U	0009368	cellular_component	endopeptidase Clp complex
U	0016787	molecular_function	hydrolase activity
U	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD A 800

Chain	Residue
A	TYR64
A	TYR66
A	ILE94

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 801

Chain	Residue
A	SER101
A	SER104
A	ILE125
A	HIS126
A	LEU157

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD B 800

Chain	Residue
B	THR161
B	GLY162
B	HOH2217
B	HOH2218
B	ARG115

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 801

Chain	Residue
B	SER101
B	SER104
B	LEU105
B	ILE125
B	HIS126

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD C 800

Chain	Residue
C	TYR66
C	TYR116
C	HOH2070
C	HOH2099
C	HOH2200

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD C 801

Chain	Residue
C	ARG115
C	HIS160
C	THR161
C	MRD802
C	HOH2208

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD C 802

Chain	Residue
C	THR161
C	GLY162
C	GLN163
C	ALA185
C	MRD801

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 803

Chain	Residue
C	SER101
C	SER104
C	LEU105
C	ILE125
C	HIS126

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT D 800

Chain	Residue
D	SER101
D	SER104
D	LEU105
D	ILE125
D	HIS126
D	LEU157

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MRD D 801

Chain	Residue
D	ARG115

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD E 800

Chain	Residue
E	ARG115
E	THR161

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT E 801

Chain	Residue
E	SER101
E	SER104
E	LEU105
E	ILE125
E	HIS126
E	LEU157

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD F 800

Chain	Residue
F	TYR64
F	ILE193
F	ARG196

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD F 801

Chain	Residue
F	THR161
F	GLY162
F	GLN163

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT F 802

Chain	Residue
F	SER101
F	SER104
F	LEU105
F	ILE125
F	HIS126

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD G 800

Chain	Residue
G	TYR64
G	TYR66
G	ARG196

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD G 801

Chain	Residue
G	ARG115
G	HIS159
G	HIS160
G	THR161
G	HOH2188

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT G 802

Chain	Residue
G	SER101
G	SER104
G	LEU105
G	ILE125
G	HIS126

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT H 800

Chain	Residue
H	SER101
H	SER104
H	LEU105
H	ILE125
H	HIS126

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MPD I 800

Chain	Residue
I	THR161

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD I 801

Chain	Residue
I	TYR64
I	TYR116
I	ILE193

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT I 802

Chain	Residue
I	SER101
I	SER104
I	ILE125
I	HIS126
I	LEU157

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD J 800

Chain	Residue
J	THR161
J	GLN163
J	ALA185
J	HOH2142

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT J 801

Chain	Residue
J	HIS126
J	SER101
J	SER104
J	LEU105
J	ILE125

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD K 800

Chain	Residue
K	TYR66
K	ARG196
L	PHE86

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD K 801

Chain	Residue
K	ARG115
K	HIS159
K	HIS160
K	THR161
K	GLY162
K	HOH2172

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD K 802

Chain	Residue
K	THR161
K	GLY162
K	GLN163

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT K 803

Chain	Residue
K	SER101
K	SER104
K	LEU105
K	ILE125
K	HIS126

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD L 800

Chain	Residue
L	TYR66
L	TYR116
L	HOH2175
M	PHE86

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD L 801

Chain	Residue
L	ARG115
L	HIS159
L	HIS160
L	THR161
L	GLY162

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT L 802

Chain	Residue
L	SER101
L	SER104
L	ILE125
L	HIS126

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD M 800

Chain	Residue
M	HIS159
M	HIS160
M	THR161

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT M 801

Chain	Residue
M	SER101
M	SER104
M	LEU105
M	ILE125
M	HIS126

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD N 800

Chain	Residue
N	TYR64
N	TYR66
N	ILE94
N	HOH2098

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MRD N 801

Chain	Residue
N	THR161
N	GLY162

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT N 802

Chain	Residue
N	SER101
N	SER104
N	LEU105
N	ILE125
N	HIS126
N	LEU157

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD O 800

Chain	Residue
O	TYR64
O	SER92
O	ILE193
O	HOH2101

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT O 801

Chain	Residue
O	SER101
O	SER104
O	ILE125
O	HIS126
O	LEU157

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD P 800

Chain	Residue
P	ARG115
P	HIS160
P	THR161
P	GLY187
P	HOH2183
P	HOH2184

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT P 801

Chain	Residue
P	SER101
P	SER104
P	LEU105
P	ILE125
P	HIS126

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD Q 800

Chain	Residue
Q	ARG115
Q	HIS159
Q	HIS160
Q	THR161
Q	HOH2157

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT Q 801

Chain	Residue
Q	SER101
Q	SER104
Q	LEU105
Q	ILE125
Q	HIS126

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT R 800

Chain	Residue
R	SER101
R	SER104
R	LEU105
R	ILE125
R	HIS126

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD S 800

Chain	Residue
S	TYR64
S	TYR66
S	ILE193
S	ARG196

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD S 801

Chain	Residue
S	THR161
S	GLY162
S	GLN163
S	ALA185
S	TYR186

site_id	FC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT S 802

Chain	Residue
S	SER101
S	SER104
S	ILE125
S	HIS126
S	LEU157

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD T 800

Chain	Residue
T	ILE94
T	ILE193
T	ARG196
T	HOH2204

site_id	FC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD T 801

Chain	Residue
T	HIS159
T	THR161
T	MRD802
T	HOH2205

site_id	FC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD T 802

Chain	Residue
T	THR161
T	GLY162
T	ALA185
T	TYR186
T	MRD801

site_id	FC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT T 803

Chain	Residue
T	SER101
T	SER104
T	LEU105
T	ILE125
T	HIS126
T	LEU157

site_id	FC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MRD U 800

Chain	Residue
U	ILE94
U	ILE193

site_id	FC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD U 801

Chain	Residue
U	ARG115
U	HIS159
U	HIS160
U	THR161

site_id	FC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT U 802

Chain	Residue
U	SER101
U	SER104
U	LEU105
U	ILE125
U	HIS126

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TicIGlAASMGS

Chain	Residue	Details
A	THR93-SER104

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyslPssqIMIHQP

Chain	Residue	Details
A	ARG115-PRO128

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	21
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)