5G1P
Aspartate transcarbamoylase domain of human CAD bound to carbamoyl phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| E | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| F | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CP D 3226 |
| Chain | Residue |
| D | SER1973 |
| E | SER2000 |
| D | THR1974 |
| D | ARG1975 |
| D | THR1976 |
| D | ARG2024 |
| D | HIS2052 |
| D | GLN2055 |
| D | PRO2184 |
| D | MET2185 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CP E 3226 |
| Chain | Residue |
| E | SER1973 |
| E | THR1974 |
| E | ARG1975 |
| E | THR1976 |
| E | ARG2024 |
| E | GLN2055 |
| E | MET2185 |
| F | SER2000 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CP F 3226 |
| Chain | Residue |
| D | SER2000 |
| F | SER1973 |
| F | THR1974 |
| F | ARG1975 |
| F | THR1976 |
| F | ARG2024 |
| F | GLN2055 |
| F | PRO2184 |
| F | MET2185 |
| F | PRO2186 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CP B 3226 |
| Chain | Residue |
| B | SER1973 |
| B | THR1974 |
| B | ARG1975 |
| B | THR1976 |
| B | ARG2024 |
| B | HIS2052 |
| B | GLN2055 |
| B | PRO2184 |
| B | MET2185 |
| B | PRO2186 |
| C | SER2000 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CP C 3226 |
| Chain | Residue |
| C | ARG1975 |
| C | THR1976 |
| C | ARG2024 |
| C | HIS2052 |
| C | GLN2055 |
| C | MET2185 |
| C | PRO2186 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CP A 3226 |
| Chain | Residue |
| A | SER1973 |
| A | THR1974 |
| A | ARG1975 |
| A | THR1976 |
| A | ARG2024 |
| A | HIS2052 |
| A | GLN2055 |
| A | PRO2184 |
| A | MET2185 |
| B | SER2000 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FyEvSTRT |
| Chain | Residue | Details |
| A | PHE1969-THR1976 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A786 |
| Chain | Residue | Details |
| A | ARG1975 | |
| A | PRO2186 | |
| B | ARG1975 | |
| B | THR1976 | |
| B | LYS2003 | |
| B | ARG2024 | |
| B | HIS2052 | |
| B | GLN2055 | |
| B | ARG2085 | |
| B | ARG2146 | |
| B | MET2185 | |
| A | THR1976 | |
| B | PRO2186 | |
| C | ARG1975 | |
| C | THR1976 | |
| C | LYS2003 | |
| C | ARG2024 | |
| C | HIS2052 | |
| C | GLN2055 | |
| C | ARG2085 | |
| C | ARG2146 | |
| C | MET2185 | |
| A | LYS2003 | |
| C | PRO2186 | |
| D | ARG1975 | |
| D | THR1976 | |
| D | LYS2003 | |
| D | ARG2024 | |
| D | HIS2052 | |
| D | GLN2055 | |
| D | ARG2085 | |
| D | ARG2146 | |
| D | MET2185 | |
| A | ARG2024 | |
| D | PRO2186 | |
| E | ARG1975 | |
| E | THR1976 | |
| E | LYS2003 | |
| E | ARG2024 | |
| E | HIS2052 | |
| E | GLN2055 | |
| E | ARG2085 | |
| E | ARG2146 | |
| E | MET2185 | |
| A | HIS2052 | |
| E | PRO2186 | |
| F | ARG1975 | |
| F | THR1976 | |
| F | LYS2003 | |
| F | ARG2024 | |
| F | HIS2052 | |
| F | GLN2055 | |
| F | ARG2085 | |
| F | ARG2146 | |
| F | MET2185 | |
| A | GLN2055 | |
| F | PRO2186 | |
| A | ARG2085 | |
| A | ARG2146 | |
| A | MET2185 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1938 | |
| B | SER1938 | |
| C | SER1938 | |
| D | SER1938 | |
| E | SER1938 | |
| F | SER1938 |
