Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 370 |
| Chain | Residue |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | HOH2277 |
| A | HOH2309 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 371 |
| Chain | Residue |
| A | LEU202 |
| A | ASP178 |
| A | ASP180 |
| A | HIS182 |
| A | SER201 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 372 |
| Chain | Residue |
| A | TRP191 |
| A | ASP194 |
| A | VAL197 |
| A | TYR226 |
| A | HOH2314 |
| A | HOH2320 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PE A 373 |
| Chain | Residue |
| A | ARG173 |
| A | PRO195 |
| A | ASN222 |
| A | TYR226 |
| A | HOH2303 |
| A | HOH2304 |
| A | HOH2325 |
| A | HOH2354 |
| A | HOH2395 |
| A | HOH2484 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 374 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 375 |
| Chain | Residue |
| A | PRO61 |
| A | ALA63 |
| A | HOH2049 |
| A | HOH2486 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 370 |
| Chain | Residue |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | HOH2228 |
| B | HOH2253 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 371 |
| Chain | Residue |
| B | ASP178 |
| B | ASP180 |
| B | HIS182 |
| B | SER201 |
| B | LEU202 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 372 |
| Chain | Residue |
| B | TRP191 |
| B | ASP194 |
| B | VAL197 |
| B | THR199 |
| B | TYR226 |
| B | HOH2258 |
| B | HOH2264 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE B 373 |
| Chain | Residue |
| B | GLU172 |
| B | ARG173 |
| B | PRO195 |
| B | ASN222 |
| B | HOH2420 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG B 374 |
| Chain | Residue |
| B | ARG355 |
| B | HOH2421 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 375 |
| Chain | Residue |
| B | ASP189 |
| B | TRP192 |
| B | ASP211 |
| B | GLU217 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 376 |
| Chain | Residue |
| A | PRO145 |
| A | ASN147 |
| A | HOH2278 |
| B | THR127 |
| B | HOH2424 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1C","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
5G1B
