Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 370 |
| Chain | Residue |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | 7H1373 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 371 |
| Chain | Residue |
| A | ASP178 |
| A | ASP180 |
| A | HIS182 |
| A | SER201 |
| A | LEU202 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 372 |
| Chain | Residue |
| A | TRP191 |
| A | ASP194 |
| A | VAL197 |
| A | THR199 |
| A | TYR226 |
| A | HOH2300 |
| A | HOH2306 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 7H1 A 373 |
| Chain | Residue |
| A | LEU21 |
| A | ILE100 |
| A | HIS142 |
| A | HIS143 |
| A | GLY151 |
| A | PHE152 |
| A | ASP180 |
| A | HIS182 |
| A | PHE208 |
| A | ASP268 |
| A | LEU275 |
| A | TYR312 |
| A | PHE341 |
| A | ZN370 |
| A | PEG379 |
| A | HOH2212 |
| A | HOH2213 |
| A | HOH2468 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE A 374 |
| Chain | Residue |
| A | ARG173 |
| A | PRO195 |
| A | ASN222 |
| A | TYR226 |
| A | HOH2291 |
| A | HOH2309 |
| A | HOH2312 |
| A | HOH2469 |
| A | HOH2470 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 375 |
| Chain | Residue |
| A | HIS205 |
| A | HOH2472 |
| A | HOH2473 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 376 |
| Chain | Residue |
| A | THR92 |
| A | HOH2202 |
| A | HOH2475 |
| A | HOH2476 |
| B | ALA23 |
| B | HOH2055 |
| B | HOH2203 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 377 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 378 |
| Chain | Residue |
| A | GLN188 |
| A | GLU217 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 379 |
| Chain | Residue |
| A | PRO337 |
| A | TYR338 |
| A | 7H1373 |
| A | HOH2478 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 370 |
| Chain | Residue |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | 7H1373 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 371 |
| Chain | Residue |
| B | ASP178 |
| B | ASP180 |
| B | HIS182 |
| B | SER201 |
| B | LEU202 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 372 |
| Chain | Residue |
| B | TRP191 |
| B | ASP194 |
| B | VAL197 |
| B | THR199 |
| B | TYR226 |
| B | HOH2282 |
| B | HOH2290 |
| site_id | BC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 7H1 B 373 |
| Chain | Residue |
| B | LEU21 |
| B | ILE100 |
| B | HIS142 |
| B | HIS143 |
| B | GLY151 |
| B | PHE152 |
| B | ASP180 |
| B | HIS182 |
| B | PHE208 |
| B | ASP268 |
| B | TYR312 |
| B | PHE341 |
| B | ZN370 |
| B | PEG376 |
| B | HOH2194 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1PE B 374 |
| Chain | Residue |
| B | GLU172 |
| B | ARG173 |
| B | PRO195 |
| B | TYR226 |
| B | HOH2145 |
| B | HOH2273 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG B 375 |
| Chain | Residue |
| B | THR92 |
| B | HOH2207 |
| B | HOH2450 |
| B | HOH2451 |
| B | HOH2452 |
| A | ALA23 |
| A | HOH2061 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 376 |
| Chain | Residue |
| B | MET30 |
| B | PRO337 |
| B | TYR338 |
| B | 7H1373 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 377 |
| Chain | Residue |
| B | ASP283 |
| B | HIS339 |
| B | HOH2372 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1C","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
