5G0X

Pseudomonas aeruginosa HDAH bound to acetate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004407	molecular_function	histone deacetylase activity
A	0016787	molecular_function	hydrolase activity
A	0040029	biological_process	epigenetic regulation of gene expression
A	0046872	molecular_function	metal ion binding
C	0004407	molecular_function	histone deacetylase activity
C	0016787	molecular_function	hydrolase activity
C	0040029	biological_process	epigenetic regulation of gene expression
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1372

Chain	Residue
A	ASP181
A	HIS183
A	ASP269
A	ACT1375

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 1373

Chain	Residue
A	ASP179
A	ASP181
A	HIS183
A	SER202
A	LEU203

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1374

Chain	Residue
A	TYR192
A	ARG195
A	VAL198
A	PHE227
A	HOH2143
A	HOH2146

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A 1375

Chain	Residue
A	HIS143
A	HIS144
A	GLY152
A	ASP181
A	HIS183
A	ASP269
A	GLY311
A	TYR313
A	ZN1372

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE A 1376

Chain	Residue
A	GLN189
A	ALA190
A	TYR193
A	GLU217
A	ASP218
A	HOH2141
A	HOH2173
A	HOH2266
C	HOH2158

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EPE A 1377

Chain	Residue
A	GLY29
A	TRP30
A	ARG258
A	HOH2267

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EPE A 1378

Chain	Residue
A	THR24
A	LEU25
A	PRO26
A	GLN100
A	ASP101
C	PRO339
C	PHE343

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1378

Chain	Residue
C	ASP181
C	HIS183
C	ASP269
C	ACT1381

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 1379

Chain	Residue
C	TYR192
C	ARG195
C	VAL198
C	PHE227
C	HOH2149
C	HOH2153

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 1380

Chain	Residue
C	ASP179
C	ASP181
C	HIS183
C	SER202
C	LEU203

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT C 1381

Chain	Residue
C	HIS143
C	HIS144
C	GLY152
C	ASP181
C	HIS183
C	ASP269
C	GLY311
C	TYR313
C	ZN1378

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EPE C 1382

Chain	Residue
C	GLN189
C	ALA190
C	TYR193
C	ASP218
C	HOH2147

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EPE C 1383

Chain	Residue
A	PHE343
C	THR24
C	ASP101
C	HOH2267

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27951649","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LI3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5G0X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---