Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FWQ

Apo structure of human Leukotriene A4 hydrolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004177	molecular_function	aminopeptidase activity
A	0004301	molecular_function	epoxide hydrolase activity
A	0004463	molecular_function	leukotriene-A4 hydrolase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006629	biological_process	lipid metabolic process
A	0006691	biological_process	leukotriene metabolic process
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0010043	biological_process	response to zinc ion
A	0016787	molecular_function	hydrolase activity
A	0019370	biological_process	leukotriene biosynthetic process
A	0043171	biological_process	peptide catabolic process
A	0043434	biological_process	response to peptide hormone
A	0045148	molecular_function	tripeptide aminopeptidase activity
A	0046872	molecular_function	metal ion binding
A	0060509	biological_process	type I pneumocyte differentiation
A	0070006	molecular_function	metalloaminopeptidase activity
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE YB A 2612

Chain	Residue
A	GLU46
A	ASP175
A	HOH2031
A	HOH2032

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A 1611

Chain	Residue
A	GLU318
A	TYR383
A	ZN1612
A	HOH2114
A	GLY269
A	GLU271
A	HIS295
A	GLU296
A	HIS299

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1612

Chain	Residue
A	HIS295
A	HIS299
A	GLU318
A	TYR383
A	ACT1611

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE YB A 1613

Chain	Residue
A	ASP47
A	ASP481
A	HOH2036
A	HOH2330
A	HOH2331
A	HOH2406
A	HOH2407

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE YB A 1614

Chain	Residue
A	GLU70
A	GLU121

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE YB A 1615

Chain	Residue
A	ASP422
A	ASP426
A	HOH2294

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE YB A 1616

Chain	Residue
A	ASP47
A	ASP481
A	HOH2036
A	HOH2330
A	HOH2331
A	HOH2406
A	HOH2407

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE YB A 1617

Chain	Residue
A	GLU46
A	ASP175
A	HOH2032

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 1618

Chain	Residue
A	GLN136
A	TYR267
A	PHE314
A	PRO374
A	ASP375
A	HOH2265

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IMD A 1619

Chain	Residue
A	TRP311
A	PHE314
A	ALA377
A	HOH2265

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 1620

Chain	Residue
A	GLY344
A	GLY347
A	GLU348
A	GLU501
A	ALA504
A	GLN508

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHEISHSW

Chain	Residue	Details
A	VAL292-TRP301

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18804029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11917124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15078870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18804029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19618939","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3U9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DPR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3U9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DPR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Pro-Gly-Pro binding","evidences":[{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Essential for epoxide hydrolase activity, but not for aminopeptidase activity","evidences":[{"source":"PubMed","id":"11917124","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Covalently modified during suicide inhibition by leukotrienes","evidences":[{"source":"PubMed","id":"7667299","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9395533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 166

Chain	Residue	Details
A	GLU271	electrostatic stabiliser, hydrogen bond acceptor, nucleofuge, nucleophile
A	HIS295	metal ligand
A	GLU296	electrostatic stabiliser
A	HIS299	metal ligand
A	GLU318	metal ligand
A	ASP375	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	TYR383	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)