5FW5
Crystal structure of human G3BP1 in complex with Semliki Forest Virus nsP3-25 comprising two FGDF motives
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1136 |
| Chain | Residue |
| A | PRO8 |
| B | HOH2101 |
| A | HIS83 |
| A | ALA84 |
| A | HOH2101 |
| A | HOH2147 |
| A | HOH2148 |
| B | TYR56 |
| B | ARG78 |
| B | HOH2070 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1139 |
| Chain | Residue |
| A | ARG78 |
| A | ARG107 |
| A | HOH2150 |
| B | LYS50 |
| B | GOL1142 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1140 |
| Chain | Residue |
| A | LYS76 |
| A | ARG78 |
| A | HOH2152 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1137 |
| Chain | Residue |
| B | LYS36 |
| B | GLY57 |
| B | GLN58 |
| B | LYS59 |
| B | HOH2034 |
| B | HOH2052 |
| B | HOH2054 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 1141 |
| Chain | Residue |
| A | HOH2019 |
| A | HOH2153 |
| B | LYS76 |
| B | ARG78 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1140 |
| Chain | Residue |
| A | SER0 |
| B | THR21 |
| B | ASN24 |
| B | HIS74 |
| B | THR75 |
| B | HOH2026 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1141 |
| Chain | Residue |
| B | PRO6 |
| B | ASP88 |
| B | GLY89 |
| B | HOH2104 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 1142 |
| Chain | Residue |
| A | SO41139 |
| B | ASP135 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K B 1143 |
| Chain | Residue |
| B | ALA26 |
| B | PRO27 |
| B | ASP28 |
| B | HOH2027 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K B 1144 |
| Chain | Residue |
| A | TYR56 |
| A | HOH2077 |
| B | ALA84 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | Binding site for residues ACT B1138 and GOL B1139 |
| Chain | Residue |
| B | GLN18 |
| B | LEU22 |
| B | HOH2022 |
| B | HOH2102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 244 |
| Details | Domain: {"description":"NTF2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00137","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34739333","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34739333","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"FGDF; binding to host G3BP1","evidences":[{"source":"PubMed","id":"25658430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24623412","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
