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5FW3

Crystal structure of SpCas9 variant VRER bound to sgRNA and TGCG PAM target DNA

Functional Information from GO Data
ChainGOidnamespacecontents
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0004519molecular_functionendonuclease activity
B0004520molecular_functionDNA endonuclease activity
B0004527molecular_functionexonuclease activity
B0008408molecular_function3'-5' exonuclease activity
B0043571biological_processmaintenance of CRISPR repeat elements
B0046872molecular_functionmetal ion binding
B0051607biological_processdefense response to virus
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1083
ChainResidue
AU22
AHOH2010
AHOH2011
AHOH2012
AHOH2053
AHOH2054

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1084
ChainResidue
AHOH2029
AHOH2030
AHOH2037
AU50
AHOH2027
AHOH2028

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K B 2366
ChainResidue
AA68
AHOH2051
BGLN1350
BHOH2075

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K B 2367
ChainResidue
BGLU584
BARG586
BASN588
BHOH2042
BHOH2043
BHOH2044

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K B 2368
ChainResidue
AA65
AU66
AHOH2045
AHOH2046
AHOH2049
BTHR1102

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A 1182
ChainResidue
AG21
AU45
AHOH2002
AHOH2011
AHOH2022

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K B 2369
ChainResidue
BLEU623
BTHR624
BPHE626
BTYR656
BHOH2048
CHOH2002

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K B 2370
ChainResidue
BGLY361
BTYR362
BGLY365
BALA367
BLYS401

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K B 2371
ChainResidue
BILE226
BLEU229
BGLU232

site_idBC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE K B 2372
ChainResidue
BALA640
BPHE643

site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE K A 1183
ChainResidue
AU12
AG13

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K B 2373
ChainResidue
BGLU57
BHOH2006
BHOH2007
BHOH2077

site_idBC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE K B 2374
ChainResidue
BLYS111
BHOH2010

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: For RuvC-like nuclease domain => ECO:0000305|PubMed:24529477
ChainResidueDetails
BALA10

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton acceptor for HNH nuclease domain => ECO:0000305|PubMed:24529477
ChainResidueDetails
BALA840

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:24505130
ChainResidueDetails
BALA10
BGLU762
BGLU766
BHIS983
BHIS1297
BASP1328

223532

PDB entries from 2024-08-07

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