5FV4

Pig liver esterase 5 (PLE5)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005811	cellular_component	lipid droplet
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0106435	molecular_function	carboxylesterase activity
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005811	cellular_component	lipid droplet
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	0106435	molecular_function	carboxylesterase activity
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005811	cellular_component	lipid droplet
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0052689	molecular_function	carboxylic ester hydrolase activity
C	0106435	molecular_function	carboxylesterase activity
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005811	cellular_component	lipid droplet
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0052689	molecular_function	carboxylic ester hydrolase activity
D	0106435	molecular_function	carboxylesterase activity
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005811	cellular_component	lipid droplet
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
E	0052689	molecular_function	carboxylic ester hydrolase activity
E	0106435	molecular_function	carboxylesterase activity
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005811	cellular_component	lipid droplet
F	0016042	biological_process	lipid catabolic process
F	0016787	molecular_function	hydrolase activity
F	0052689	molecular_function	carboxylic ester hydrolase activity
F	0106435	molecular_function	carboxylesterase activity

Functional Information from PROSITE/UniProt

site_id	PS00122
Number of Residues	16
Details	CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpgsVtIfGeSAG

Chain	Residue	Details
A	PHE191-GLY206

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site_id	PS00941
Number of Residues	11
Details	CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIYtP

Chain	Residue	Details
A	GLU97-PRO107

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10039

Chain	Residue	Details
A	SER204
B	SER204
C	SER204
D	SER204
E	SER204
F	SER204

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site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
A	GLU336
E	HIS449
F	GLU336
F	HIS449
A	HIS449
B	GLU336
B	HIS449
C	GLU336
C	HIS449
D	GLU336
D	HIS449
E	GLU336

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site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23141

Chain	Residue	Details
A	SER361
B	SER361
C	SER361
D	SER361
E	SER361
F	SER361

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site_id	SWS_FT_FI4
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN62
B	ASN62
C	ASN62
D	ASN62
E	ASN62
F	ASN62

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