5FTI
Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU A 900 |
| Chain | Residue |
| A | TYR450 |
| A | TYR732 |
| A | HOH2165 |
| A | HOH2166 |
| A | HOH2274 |
| A | PRO478 |
| A | LEU479 |
| A | THR480 |
| A | ARG485 |
| A | GLY653 |
| A | SER654 |
| A | THR655 |
| A | GLU705 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LI A 901 |
| Chain | Residue |
| A | GLU486 |
| A | ILE489 |
| A | ASP490 |
| A | MET738 |
| A | HOH2111 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 902 |
| Chain | Residue |
| A | SER652 |
| A | LYS656 |
| A | ARG660 |
| A | HOH2071 |
| A | HOH2085 |
| A | HOH2167 |
| A | HOH2169 |
| A | HOH2382 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 903 |
| Chain | Residue |
| A | MET408 |
| A | HIS412 |
| A | ARG420 |
| A | HOH2020 |
| A | HOH2033 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 904 |
| Chain | Residue |
| A | ARG660 |
| A | TRP671 |
| A | ARG675 |
| A | HOH2184 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU B 900 |
| Chain | Residue |
| B | TYR450 |
| B | PRO478 |
| B | LEU479 |
| B | THR480 |
| B | ARG485 |
| B | GLY653 |
| B | SER654 |
| B | THR655 |
| B | GLU705 |
| B | TYR732 |
| B | HOH2143 |
| B | HOH2144 |
| B | HOH2225 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LI B 901 |
| Chain | Residue |
| B | GLU486 |
| B | ILE489 |
| B | ASP490 |
| B | HOH2097 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 902 |
| Chain | Residue |
| B | SER652 |
| B | LYS656 |
| B | ARG660 |
| B | HOH2080 |
| B | HOH2147 |
| B | HOH2148 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 903 |
| Chain | Residue |
| A | LYS695 |
| A | HOH2269 |
| B | ARG420 |
| B | HOH2022 |
| B | HOH2024 |
| B | HOH2034 |
| B | HOH2038 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 904 |
| Chain | Residue |
| B | ARG660 |
| B | TRP671 |
| B | ARG675 |
| B | HOH2151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
