Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FT8

Crystal structure of the complex between the cysteine desulfurase CsdA and the sulfur-acceptor CsdE in the persulfurated state at 2.50 Angstroem resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000096	biological_process	sulfur amino acid metabolic process
A	0005515	molecular_function	protein binding
A	0006534	biological_process	cysteine metabolic process
A	0008826	molecular_function	cysteine sulfinate desulfinase activity
A	0009000	molecular_function	selenocysteine lyase activity
A	0016226	biological_process	iron-sulfur cluster assembly
A	0016261	biological_process	selenocysteine catabolic process
A	0016740	molecular_function	transferase activity
A	0016783	molecular_function	sulfurtransferase activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0019448	biological_process	L-cysteine catabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031071	molecular_function	cysteine desulfurase activity
A	0072348	biological_process	sulfur compound transport
A	1990221	cellular_component	L-cysteine desulfurase complex
C	0000096	biological_process	sulfur amino acid metabolic process
C	0005515	molecular_function	protein binding
C	0006534	biological_process	cysteine metabolic process
C	0008826	molecular_function	cysteine sulfinate desulfinase activity
C	0009000	molecular_function	selenocysteine lyase activity
C	0016226	biological_process	iron-sulfur cluster assembly
C	0016261	biological_process	selenocysteine catabolic process
C	0016740	molecular_function	transferase activity
C	0016783	molecular_function	sulfurtransferase activity
C	0016787	molecular_function	hydrolase activity
C	0016829	molecular_function	lyase activity
C	0019448	biological_process	L-cysteine catabolic process
C	0030170	molecular_function	pyridoxal phosphate binding
C	0031071	molecular_function	cysteine desulfurase activity
C	0072348	biological_process	sulfur compound transport
C	1990221	cellular_component	L-cysteine desulfurase complex
E	0000096	biological_process	sulfur amino acid metabolic process
E	0005515	molecular_function	protein binding
E	0006534	biological_process	cysteine metabolic process
E	0008826	molecular_function	cysteine sulfinate desulfinase activity
E	0009000	molecular_function	selenocysteine lyase activity
E	0016226	biological_process	iron-sulfur cluster assembly
E	0016261	biological_process	selenocysteine catabolic process
E	0016740	molecular_function	transferase activity
E	0016783	molecular_function	sulfurtransferase activity
E	0016787	molecular_function	hydrolase activity
E	0016829	molecular_function	lyase activity
E	0019448	biological_process	L-cysteine catabolic process
E	0030170	molecular_function	pyridoxal phosphate binding
E	0031071	molecular_function	cysteine desulfurase activity
E	0072348	biological_process	sulfur compound transport
E	1990221	cellular_component	L-cysteine desulfurase complex
G	0000096	biological_process	sulfur amino acid metabolic process
G	0005515	molecular_function	protein binding
G	0006534	biological_process	cysteine metabolic process
G	0008826	molecular_function	cysteine sulfinate desulfinase activity
G	0009000	molecular_function	selenocysteine lyase activity
G	0016226	biological_process	iron-sulfur cluster assembly
G	0016261	biological_process	selenocysteine catabolic process
G	0016740	molecular_function	transferase activity
G	0016783	molecular_function	sulfurtransferase activity
G	0016787	molecular_function	hydrolase activity
G	0016829	molecular_function	lyase activity
G	0019448	biological_process	L-cysteine catabolic process
G	0030170	molecular_function	pyridoxal phosphate binding
G	0031071	molecular_function	cysteine desulfurase activity
G	0072348	biological_process	sulfur compound transport
G	1990221	cellular_component	L-cysteine desulfurase complex
I	0000096	biological_process	sulfur amino acid metabolic process
I	0005515	molecular_function	protein binding
I	0006534	biological_process	cysteine metabolic process
I	0008826	molecular_function	cysteine sulfinate desulfinase activity
I	0009000	molecular_function	selenocysteine lyase activity
I	0016226	biological_process	iron-sulfur cluster assembly
I	0016261	biological_process	selenocysteine catabolic process
I	0016740	molecular_function	transferase activity
I	0016783	molecular_function	sulfurtransferase activity
I	0016787	molecular_function	hydrolase activity
I	0016829	molecular_function	lyase activity
I	0019448	biological_process	L-cysteine catabolic process
I	0030170	molecular_function	pyridoxal phosphate binding
I	0031071	molecular_function	cysteine desulfurase activity
I	0072348	biological_process	sulfur compound transport
I	1990221	cellular_component	L-cysteine desulfurase complex
K	0000096	biological_process	sulfur amino acid metabolic process
K	0005515	molecular_function	protein binding
K	0006534	biological_process	cysteine metabolic process
K	0008826	molecular_function	cysteine sulfinate desulfinase activity
K	0009000	molecular_function	selenocysteine lyase activity
K	0016226	biological_process	iron-sulfur cluster assembly
K	0016261	biological_process	selenocysteine catabolic process
K	0016740	molecular_function	transferase activity
K	0016783	molecular_function	sulfurtransferase activity
K	0016787	molecular_function	hydrolase activity
K	0016829	molecular_function	lyase activity
K	0019448	biological_process	L-cysteine catabolic process
K	0030170	molecular_function	pyridoxal phosphate binding
K	0031071	molecular_function	cysteine desulfurase activity
K	0072348	biological_process	sulfur compound transport
K	1990221	cellular_component	L-cysteine desulfurase complex
M	0000096	biological_process	sulfur amino acid metabolic process
M	0005515	molecular_function	protein binding
M	0006534	biological_process	cysteine metabolic process
M	0008826	molecular_function	cysteine sulfinate desulfinase activity
M	0009000	molecular_function	selenocysteine lyase activity
M	0016226	biological_process	iron-sulfur cluster assembly
M	0016261	biological_process	selenocysteine catabolic process
M	0016740	molecular_function	transferase activity
M	0016783	molecular_function	sulfurtransferase activity
M	0016787	molecular_function	hydrolase activity
M	0016829	molecular_function	lyase activity
M	0019448	biological_process	L-cysteine catabolic process
M	0030170	molecular_function	pyridoxal phosphate binding
M	0031071	molecular_function	cysteine desulfurase activity
M	0072348	biological_process	sulfur compound transport
M	1990221	cellular_component	L-cysteine desulfurase complex
O	0000096	biological_process	sulfur amino acid metabolic process
O	0005515	molecular_function	protein binding
O	0006534	biological_process	cysteine metabolic process
O	0008826	molecular_function	cysteine sulfinate desulfinase activity
O	0009000	molecular_function	selenocysteine lyase activity
O	0016226	biological_process	iron-sulfur cluster assembly
O	0016261	biological_process	selenocysteine catabolic process
O	0016740	molecular_function	transferase activity
O	0016783	molecular_function	sulfurtransferase activity
O	0016787	molecular_function	hydrolase activity
O	0016829	molecular_function	lyase activity
O	0019448	biological_process	L-cysteine catabolic process
O	0030170	molecular_function	pyridoxal phosphate binding
O	0031071	molecular_function	cysteine desulfurase activity
O	0072348	biological_process	sulfur compound transport
O	1990221	cellular_component	L-cysteine desulfurase complex
Q	0005515	molecular_function	protein binding
Q	0008047	molecular_function	enzyme activator activity
Q	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
Q	0097163	molecular_function	sulfur carrier activity
Q	1990228	cellular_component	sulfurtransferase complex
S	0005515	molecular_function	protein binding
S	0008047	molecular_function	enzyme activator activity
S	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
S	0097163	molecular_function	sulfur carrier activity
S	1990228	cellular_component	sulfurtransferase complex
U	0005515	molecular_function	protein binding
U	0008047	molecular_function	enzyme activator activity
U	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
U	0097163	molecular_function	sulfur carrier activity
U	1990228	cellular_component	sulfurtransferase complex
W	0005515	molecular_function	protein binding
W	0008047	molecular_function	enzyme activator activity
W	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
W	0097163	molecular_function	sulfur carrier activity
W	1990228	cellular_component	sulfurtransferase complex
Y	0005515	molecular_function	protein binding
Y	0008047	molecular_function	enzyme activator activity
Y	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
Y	0097163	molecular_function	sulfur carrier activity
Y	1990228	cellular_component	sulfurtransferase complex
a	0005515	molecular_function	protein binding
a	0008047	molecular_function	enzyme activator activity
a	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
a	0097163	molecular_function	sulfur carrier activity
a	1990228	cellular_component	sulfurtransferase complex
c	0005515	molecular_function	protein binding
c	0008047	molecular_function	enzyme activator activity
c	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
c	0097163	molecular_function	sulfur carrier activity
c	1990228	cellular_component	sulfurtransferase complex
e	0005515	molecular_function	protein binding
e	0008047	molecular_function	enzyme activator activity
e	0061504	biological_process	cyclic threonylcarbamoyladenosine biosynthetic process
e	0097163	molecular_function	sulfur carrier activity
e	1990228	cellular_component	sulfurtransferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP A 501

Chain	Residue
A	THR90
A	LYS222
A	HOH654
A	HOH692
C	THR273
A	THR91
A	HIS119
A	ASN171
A	ASP196
A	ALA198
A	GLN199
A	SER219
A	HIS221

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CSS A 358

Chain	Residue
A	HIS119
A	HIS120
A	GLN356
A	HIS357
A	ALA359
C	HOH703
C	GLY249
C	LYS250

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG A 502

Chain	Residue
A	GLN99
A	ARG103
A	PRO244
A	TRP245
C	GLN99
C	ARG103
C	MET128
C	GLN132

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG A 503

Chain	Residue
A	ARG60
A	ALA63
A	ARG64
A	ALA67
A	LYS71
A	GLU287
A	HOH635

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 504

Chain	Residue
A	GLN41
A	SER44
A	GLN54

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 505

Chain	Residue
A	HIS187
A	ASP212

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 506

Chain	Residue
A	MET1
A	VAL3
A	GLN8
A	ASP291
A	TYR292

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 507

Chain	Residue
A	GLU37
A	GLN41
A	GLU57

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 508

Chain	Residue
A	LYS314
A	ARG315
A	HOH680
A	HOH673

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 509

Chain	Residue
A	ASN143
A	GLN145
A	ASP149
A	ASP151

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 510

Chain	Residue
A	PHE42
A	THR62

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 511

Chain	Residue
A	THR306
A	GLU309
A	ASP310
A	ASP325
A	GOL512
A	HOH607

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 512

Chain	Residue
A	GLU309
A	ASP310
A	ALA313
A	GOL511
A	HOH678

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 513

Chain	Residue
A	ALA364
A	GLU365
A	LEU366
A	GLY367

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 514

Chain	Residue
A	GLN74

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 515

Chain	Residue
A	ASP258

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CSS Q 61

Chain	Residue
A	GLY355
A	GLN356
A	HOH618
A	HOH723
Q	GLY60
Q	GLU62
Q	ASN63

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG Q 201

Chain	Residue
Q	SER126
Q	ALA127
Q	SER128
Q	ARG129
Q	SER130
Q	GLN131
G	GLU155

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL Q 202

Chain	Residue
Q	SER111
Q	HOH308

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL Q 203

Chain	Residue
A	GLU347
Q	TRP30
Q	HOH326

site_id	CC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP C 501

Chain	Residue
C	HIS119
C	ASN171
C	ASP196
C	ALA198
C	GLN199
C	SER219
C	HIS221
C	LYS222
C	HOH623
C	HOH641
A	THR273
A	HOH624
C	THR90
C	THR91

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CSS C 358

Chain	Residue
A	GLY249
C	HIS119
C	HIS120
C	GLN356
C	HIS357
C	ALA359

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG C 502

Chain	Residue
C	THR261
C	HOH622

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG C 503

Chain	Residue
C	VAL137
C	VAL138
C	PEG504
C	HOH636

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG C 504

Chain	Residue
C	GLU111
C	PEG503
C	HOH636

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG C 505

Chain	Residue
C	GLN74
C	GOL509
C	HOH654
C	HOH639

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 506

Chain	Residue
C	GLU240
C	HOH604
I	SER188

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 507

Chain	Residue
C	THR62
C	GOL508

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL C 508

Chain	Residue
C	GOL507

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 509

Chain	Residue
C	GLU70
C	GLN74
C	ASN77
C	ALA78
C	PRO79
C	PEG505
C	HOH654

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL C 510

Chain	Residue
C	PRO316

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 511

Chain	Residue
C	ALA364
C	GLY367

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 512

Chain	Residue
C	PRO108
I	GLN107
I	PRO108

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 513

Chain	Residue
C	GLY367
C	THR369
C	HOH617
C	HOH640

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 514

Chain	Residue
C	GLU309
C	ASP310
C	ASP325

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 515

Chain	Residue
C	TYR65
C	ARG69
C	TRP86

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 516

Chain	Residue
A	VAL137
C	ASP258
U	GLU18
U	ARG21

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CSS S 61

Chain	Residue
C	ALA354
S	GLY60
S	GLU62
S	ASN63

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL S 201

Chain	Residue
S	LEU27
S	LYS33
S	GLU118
S	LEU119
S	GLY120
E	LYS136

site_id	EC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP E 501

Chain	Residue
E	THR90
E	THR91
E	HIS119
E	ASN171
E	ASP196
E	ALA198
E	GLN199
E	SER219
E	HIS221
E	LYS222
E	HOH673
E	HOH605
G	HOH606
G	THR273

site_id	EC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CSS E 358

Chain	Residue
E	HIS119
E	HIS120
E	GLN356
E	HIS357
E	ALA359
G	GLY249
G	LYS250

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG E 502

Chain	Residue
E	ARG302

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG E 503

Chain	Residue
E	ASP212
E	GOL515
E	HOH680

site_id	EC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG E 504

Chain	Residue
E	GLN132

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG E 505

Chain	Residue
E	ARG103
E	GLN132
E	HOH604
E	HOH639
G	ARG103

site_id	FC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL E 506

Chain	Residue
E	THR262
E	GLN263

site_id	FC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL E 507

Chain	Residue
E	GLU237
E	ALA241

site_id	FC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL E 508

Chain	Residue
E	GLU66

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL E 509

Chain	Residue
A	GLN59
E	PRO104
E	ARG105
E	GLN107

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL E 510

Chain	Residue
E	ARG10
E	LEU16
E	GLN17

site_id	FC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL E 511

Chain	Residue
E	HOH666
I	ASP149

site_id	FC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 512

Chain	Residue
E	CYS176
E	PRO177
E	ASP178
E	GLN324
E	HOH638

site_id	FC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL E 513

Chain	Residue
E	ASP80
E	LYS82

site_id	FC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL E 514

Chain	Residue
E	ASN77

site_id	GC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL E 515

Chain	Residue
E	PEG503

site_id	GC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CSS U 61

Chain	Residue
E	GLY355
E	HIS357
E	HOH671
U	GLY60
U	GLU62
U	ASN63

site_id	GC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP G 501

Chain	Residue
E	THR273
G	HOH646
G	HOH671
G	THR90
G	THR91
G	HIS119
G	ASN171
G	ASP196
G	ALA198
G	GLN199
G	SER219
G	HIS221
G	LYS222

site_id	GC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CSS G 358

Chain	Residue
E	GLY249
E	HOH662
G	HIS119
G	HIS120
G	GLN356
G	HIS357
G	ALA359

site_id	GC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG G 502

Chain	Residue
E	GLN131
G	ASP258

site_id	GC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL G 503

Chain	Residue
E	ASN49
G	HOH607
G	ASP24
G	VAL342
G	LEU352
G	ARG353
G	HOH603

site_id	GC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL G 504

Chain	Residue
G	SER303
G	THR306
G	LEU307

site_id	GC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL G 505

Chain	Residue
G	MET1

site_id	GC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL G 506

Chain	Residue
G	HIS51
G	PHE55

site_id	HC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL G 507

Chain	Residue
G	PRO79
G	ASP80

site_id	HC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL G 508

Chain	Residue
G	ALA313
G	ARG315
G	PRO316
G	GLY317
G	PHE318
G	HOH658

site_id	HC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL G 509

Chain	Residue
G	GLN40

site_id	HC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CSS W 61

Chain	Residue
G	GLN356
W	GLY60
W	GLU62
W	ASN63

site_id	HC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG W 201

Chain	Residue
W	PRO48
W	ASP49

site_id	HC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL W 202

Chain	Residue
A	GLN17
C	ARG52
C	SER53
W	GLN146
W	LYS148

site_id	HC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP I 501

Chain	Residue
I	THR90
I	THR91
I	HIS119
I	ASN171
I	ASP196
I	ALA198
I	GLN199
I	SER219
I	HIS221
I	LYS222
I	HOH655
I	HOH652
K	THR273

site_id	HC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CSS I 358

Chain	Residue
I	HIS119
I	HIS120
I	GLN356
I	HIS357
I	ALA359
Y	CSS61
K	GLY249
K	LYS250

site_id	HC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG I 502

Chain	Residue
I	PRO108
I	GLY134
I	LYS136
I	HOH606
I	HOH605

site_id	IC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL I 503

Chain	Residue
I	ASN2
I	VAL3
I	PHE4
I	ASN5
I	ASP293

site_id	IC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL I 504

Chain	Residue
I	GLU33

site_id	IC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL I 505

Chain	Residue
I	ASP386
I	ALA387
I	ASN390

site_id	IC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL I 506

Chain	Residue
C	HOH650
I	LYS235
I	GLU237

site_id	IC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CSS Y 61

Chain	Residue
I	GLY355
I	GLN356
I	HIS357
I	CSS358
I	HOH669
Y	GLY60
Y	GLU62
Y	ASN63

site_id	IC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP K 501

Chain	Residue
I	THR273
K	HOH617
I	HOH610
K	THR90
K	THR91
K	HIS119
K	ASN171
K	ASP196
K	ALA198
K	GLN199
K	SER219
K	HIS221
K	LYS222

site_id	IC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CSS K 358

Chain	Residue
I	GLY249
K	HIS119
K	HIS120
K	GLN356
K	HIS357
K	ALA359

site_id	IC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG K 502

Chain	Residue
K	GLN263
K	TRP267

site_id	IC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CSS a 61

Chain	Residue
K	GLN356
a	HOH202
a	GLY60
a	GLU62
a	ASN63
a	HOH205

site_id	JC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP M 501

Chain	Residue
M	THR90
M	THR91
M	HIS119
M	ASN171
M	ASP196
M	ALA198
M	GLN199
M	SER219
M	HIS221
M	LYS222
O	THR273

site_id	JC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CSS M 358

Chain	Residue
M	HIS119
M	HIS120
M	GLN356
M	HIS357
M	ALA359
O	GLY249

site_id	JC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL M 502

Chain	Residue
K	LYS314
M	ASP310

site_id	JC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CSS c 61

Chain	Residue
M	GLN356
c	GLY60
c	GLU62
c	ASN63

site_id	JC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP O 501

Chain	Residue
M	THR273
O	THR90
O	THR91
O	HIS119
O	ASN171
O	ASP196
O	ALA198
O	GLN199
O	SER219
O	HIS221
O	LYS222

site_id	JC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CSS O 358

Chain	Residue
O	HIS119
O	HIS120
O	GLN356
O	HIS357
O	ALA359

Functional Information from PROSITE/UniProt

site_id	PS00595
Number of Residues	20
Details	AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDFYafSGHKlygpt.GiGvL

Chain	Residue	Details
A	ILE213-LEU232

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"PubMed","id":"10739946","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	7
Details	Active site: {"description":"Cysteine persulfide intermediate"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"Cysteine persulfide","evidences":[{"source":"PubMed","id":"15901727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)