5FT4
Crystal structure of the cysteine desulfurase CsdA from Escherichia coli at 1.996 Angstroem resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000096 | biological_process | sulfur amino acid metabolic process |
| A | 0005515 | molecular_function | protein binding |
| A | 0006534 | biological_process | cysteine metabolic process |
| A | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| A | 0009000 | molecular_function | selenocysteine lyase activity |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0016261 | biological_process | selenocysteine catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019448 | biological_process | L-cysteine catabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031071 | molecular_function | cysteine desulfurase activity |
| A | 0072348 | biological_process | sulfur compound transport |
| B | 0000096 | biological_process | sulfur amino acid metabolic process |
| B | 0005515 | molecular_function | protein binding |
| B | 0006534 | biological_process | cysteine metabolic process |
| B | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| B | 0009000 | molecular_function | selenocysteine lyase activity |
| B | 0016226 | biological_process | iron-sulfur cluster assembly |
| B | 0016261 | biological_process | selenocysteine catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019448 | biological_process | L-cysteine catabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0031071 | molecular_function | cysteine desulfurase activity |
| B | 0072348 | biological_process | sulfur compound transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP A 1401 |
| Chain | Residue |
| A | THR91 |
| A | LYS222 |
| A | CIT1404 |
| A | HOH2112 |
| A | HOH2117 |
| A | HOH2300 |
| B | THR273 |
| A | HIS119 |
| A | ALA121 |
| A | ASN171 |
| A | ASP196 |
| A | ALA198 |
| A | GLN199 |
| A | SER219 |
| A | HIS221 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLP B 1401 |
| Chain | Residue |
| A | GLY272 |
| A | THR273 |
| A | HOH2222 |
| A | HOH2238 |
| B | THR90 |
| B | THR91 |
| B | HIS119 |
| B | ASN171 |
| B | ASP196 |
| B | ALA198 |
| B | GLN199 |
| B | SER219 |
| B | HIS221 |
| B | LYS222 |
| B | CIT1406 |
| B | HOH2089 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 1402 |
| Chain | Residue |
| B | GLN263 |
| B | TRP267 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1403 |
| Chain | Residue |
| B | PRO104 |
| B | HOH2095 |
| B | HOH2275 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1402 |
| Chain | Residue |
| A | TYR65 |
| A | ARG69 |
| A | TRP86 |
| A | TRP267 |
| A | HOH2089 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1403 |
| Chain | Residue |
| A | GLN99 |
| A | ARG103 |
| A | TRP245 |
| A | HOH2215 |
| A | HOH2301 |
| B | GLN99 |
| B | ARG103 |
| B | GLN132 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1404 |
| Chain | Residue |
| B | ALA47 |
| B | THR62 |
| B | TYR65 |
| B | HOH2276 |
| B | HOH2277 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1405 |
| Chain | Residue |
| B | TYR65 |
| B | ARG69 |
| B | TRP86 |
| B | TRP267 |
| B | HOH2055 |
| B | HOH2199 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CIT A 1404 |
| Chain | Residue |
| A | ALA26 |
| A | ALA27 |
| A | HIS119 |
| A | ASN171 |
| A | LYS222 |
| A | ARG353 |
| A | HIS357 |
| A | CYS358 |
| A | ARG373 |
| A | PLP1401 |
| A | HOH2045 |
| A | HOH2276 |
| A | HOH2300 |
| B | LYS250 |
| B | THR273 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CIT B 1406 |
| Chain | Residue |
| A | LYS250 |
| A | THR273 |
| A | HOH2222 |
| B | ALA26 |
| B | ALA27 |
| B | HIS119 |
| B | ASN171 |
| B | LYS222 |
| B | ARG353 |
| B | HIS357 |
| B | CYS358 |
| B | ARG373 |
| B | PLP1401 |
| B | HOH2022 |
| B | HOH2249 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CIT B 1407 |
| Chain | Residue |
| B | ASN5 |
| B | PRO6 |
| B | ALA7 |
| B | ARG10 |
| B | HOH2279 |
| B | HOH2280 |
| B | HOH2281 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT B 1408 |
| Chain | Residue |
| B | SER339 |
| B | ALA354 |
| B | GLY355 |
| B | GLY370 |
| B | THR371 |
| B | HOH2240 |
| B | HOH2283 |
| B | HIS337 |
| B | HIS338 |
Functional Information from PROSITE/UniProt
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDFYafSGHKlygpt.GiGvL |
| Chain | Residue | Details |
| A | ILE213-LEU232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"PubMed","id":"10739946","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
