5FS9
Crystal structure of the G338E mutant of human apoptosis inducing factor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 1000 |
| Chain | Residue |
| A | GLY138 |
| A | SER176 |
| A | LYS177 |
| A | LYS231 |
| A | LYS232 |
| A | VAL233 |
| A | ALA259 |
| A | THR260 |
| A | GLY261 |
| A | ARG285 |
| A | GLY437 |
| A | GLY139 |
| A | ASP438 |
| A | GLU453 |
| A | HIS454 |
| A | HIS455 |
| A | ALA458 |
| A | PHE482 |
| A | TRP483 |
| A | HOH2006 |
| A | HOH2009 |
| A | HOH2010 |
| A | GLY140 |
| A | HOH2012 |
| A | HOH2029 |
| A | HOH2089 |
| A | HOH2090 |
| A | HOH2133 |
| A | HOH2214 |
| A | HOH2274 |
| A | THR141 |
| A | ALA142 |
| A | VAL162 |
| A | GLU164 |
| A | ARG172 |
| A | PRO173 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1002 |
| Chain | Residue |
| A | MET481 |
| A | SER530 |
| A | MET585 |
| A | ARG589 |
| B | HIS611 |
| site_id | AC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD B 1000 |
| Chain | Residue |
| B | GLY138 |
| B | GLY139 |
| B | GLY140 |
| B | THR141 |
| B | ALA142 |
| B | VAL162 |
| B | GLU164 |
| B | ASP165 |
| B | ARG172 |
| B | PRO173 |
| B | SER176 |
| B | LYS177 |
| B | LYS231 |
| B | VAL233 |
| B | ALA259 |
| B | THR260 |
| B | GLY261 |
| B | PHE284 |
| B | ARG285 |
| B | GLY437 |
| B | ASP438 |
| B | GLU453 |
| B | HIS454 |
| B | HIS455 |
| B | ALA458 |
| B | PHE482 |
| B | TRP483 |
| B | HOH2006 |
| B | HOH2007 |
| B | HOH2009 |
| B | HOH2072 |
| B | HOH2073 |
| B | HOH2117 |
| B | HOH2167 |
| B | HOH2207 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1001 |
| Chain | Residue |
| B | MET481 |
| B | ARG529 |
| B | SER530 |
| B | MET585 |
| B | PRO586 |
| B | ARG589 |
| B | HOH2275 |
| B | HOH2276 |
| B | HOH2277 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVI |
| Chain | Residue | Details |
| A | GLY138 | |
| B | GLY138 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH, ECO:0007744|PDB:5KVI |
| Chain | Residue | Details |
| A | GLU164 | |
| A | ARG172 | |
| A | VAL233 | |
| A | ASP438 | |
| B | GLU164 | |
| B | ARG172 | |
| B | VAL233 | |
| B | ASP438 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVI |
| Chain | Residue | Details |
| A | LYS177 | |
| B | LYS177 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24914854, ECO:0007744|PDB:4BUR |
| Chain | Residue | Details |
| A | TRP196 | |
| B | GLU336 | |
| B | GLY399 | |
| B | GLU453 | |
| B | GLU493 | |
| B | ASN583 | |
| A | GLY308 | |
| A | GLU336 | |
| A | GLY399 | |
| A | GLU453 | |
| A | GLU493 | |
| A | ASN583 | |
| B | TRP196 | |
| B | GLY308 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH |
| Chain | Residue | Details |
| A | ARG285 | |
| B | ARG285 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9Z0X1 |
| Chain | Residue | Details |
| A | LYS342 | |
| B | LYS342 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH, ECO:0007744|PDB:5KVI |
| Chain | Residue | Details |
| A | HIS454 | |
| B | HIS454 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24914854, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6 |
| Chain | Residue | Details |
| A | TRP483 | |
| B | TRP483 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR105 | |
| B | THR105 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9Z0X1 |
| Chain | Residue | Details |
| A | LYS109 | |
| B | LYS109 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER116 | |
| B | SER116 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER118 | |
| A | SER371 | |
| A | SER524 | |
| A | SER530 | |
| B | SER118 | |
| B | SER371 | |
| B | SER524 | |
| B | SER530 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER268 | |
| B | SER268 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER292 | |
| B | SER292 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9Z0X1 |
| Chain | Residue | Details |
| A | LYS388 | |
| A | LYS593 | |
| B | LYS388 | |
| B | LYS593 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR521 | |
| B | THR521 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:22103349 |
| Chain | Residue | Details |
| A | LYS255 | |
| B | LYS255 |
