5FS8
Crystal structure of the G308E mutant of human apoptosis inducing factor
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 40 |
Details | BINDING SITE FOR RESIDUE FAD A 1000 |
Chain | Residue |
A | GLY138 |
A | PRO173 |
A | SER176 |
A | LYS177 |
A | LYS231 |
A | LYS232 |
A | VAL233 |
A | ALA259 |
A | THR260 |
A | GLY261 |
A | ARG285 |
A | GLY139 |
A | LYS286 |
A | ASN403 |
A | GLY437 |
A | ASP438 |
A | GLU453 |
A | HIS454 |
A | HIS455 |
A | ALA458 |
A | PHE482 |
A | TRP483 |
A | GLY140 |
A | HOH2013 |
A | HOH2016 |
A | HOH2017 |
A | HOH2019 |
A | HOH2058 |
A | HOH2233 |
A | HOH2237 |
A | HOH2304 |
A | HOH2350 |
A | HOH2453 |
A | THR141 |
A | HOH2521 |
A | ALA142 |
A | VAL162 |
A | GLU164 |
A | ASP165 |
A | ARG172 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
A | GLY138 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
A | GLU164 | |
A | ARG172 | |
A | VAL233 | |
A | ASP438 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
A | LYS177 |
site_id | SWS_FT_FI4 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24914854, ECO:0007744|PDB:4BUR |
Chain | Residue | Details |
A | TRP196 | |
A | GLU308 | |
A | GLU336 | |
A | GLY399 | |
A | GLU453 | |
A | GLU493 | |
A | ASN583 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH |
Chain | Residue | Details |
A | ARG285 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9Z0X1 |
Chain | Residue | Details |
A | LYS342 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
A | HIS454 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24914854, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6 |
Chain | Residue | Details |
A | TRP483 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR105 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9Z0X1 |
Chain | Residue | Details |
A | LYS109 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER116 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER118 | |
A | SER371 | |
A | SER524 | |
A | SER530 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER268 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER292 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9Z0X1 |
Chain | Residue | Details |
A | LYS388 | |
A | LYS593 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR521 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:22103349 |
Chain | Residue | Details |
A | LYS255 |