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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FS8

Crystal structure of the G308E mutant of human apoptosis inducing factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	40
Details	BINDING SITE FOR RESIDUE FAD A 1000

Chain	Residue
A	GLY138
A	PRO173
A	SER176
A	LYS177
A	LYS231
A	LYS232
A	VAL233
A	ALA259
A	THR260
A	GLY261
A	ARG285
A	GLY139
A	LYS286
A	ASN403
A	GLY437
A	ASP438
A	GLU453
A	HIS454
A	HIS455
A	ALA458
A	PHE482
A	TRP483
A	GLY140
A	HOH2013
A	HOH2016
A	HOH2017
A	HOH2019
A	HOH2058
A	HOH2233
A	HOH2237
A	HOH2304
A	HOH2350
A	HOH2453
A	THR141
A	HOH2521
A	ALA142
A	VAL162
A	GLU164
A	ASP165
A	ARG172

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:23217327, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	GLY138

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:23217327, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVH, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	GLU164
A	ARG172
A	VAL233
A	ASP438

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	LYS177

site_id	SWS_FT_FI4
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269\|PubMed:24914854, ECO:0007744\|PDB:4BUR

Chain	Residue	Details
A	TRP196
A	GLU308
A	GLU336
A	GLY399
A	GLU453
A	GLU493
A	ASN583

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:23217327, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVH

Chain	Residue	Details
A	ARG285

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q9Z0X1

Chain	Residue	Details
A	LYS342

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVH, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	HIS454

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:24914854, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6

Chain	Residue	Details
A	TRP483

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR105

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9Z0X1

Chain	Residue	Details
A	LYS109

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER116

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER118
A	SER371
A	SER524
A	SER530

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER268

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER292

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9Z0X1

Chain	Residue	Details
A	LYS388
A	LYS593

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR521

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:22103349

Chain	Residue	Details
A	LYS255

224004

PDB entries from 2024-08-21

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