5FS6

Crystal structure of the V243L mutant of human apoptosis inducing factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0046983	molecular_function	protein dimerization activity
B	0016491	molecular_function	oxidoreductase activity
B	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	39
Details	BINDING SITE FOR RESIDUE FAD A 1000

Chain	Residue
A	GLY138
A	PRO173
A	SER176
A	LYS177
A	LYS232
A	VAL233
A	ALA259
A	THR260
A	GLY261
A	PHE284
A	ARG285
A	GLY139
A	LYS286
A	LEU311
A	GLY437
A	ASP438
A	GLU453
A	HIS454
A	HIS455
A	ALA458
A	PHE482
A	TRP483
A	GLY140
A	HOH2008
A	HOH2009
A	HOH2013
A	HOH2015
A	HOH2137
A	HOH2138
A	HOH2214
A	HOH2215
A	HOH2299
A	HOH2362
A	THR141
A	ALA142
A	VAL162
A	GLU164
A	ASP165
A	ARG172

---

site_id	AC2
Number of Residues	39
Details	BINDING SITE FOR RESIDUE FAD B 1000

Chain	Residue
B	GLY138
B	GLY139
B	GLY140
B	THR141
B	ALA142
B	VAL162
B	GLU164
B	ASP165
B	ARG172
B	PRO173
B	SER176
B	LYS177
B	LYS231
B	LYS232
B	VAL233
B	ALA259
B	THR260
B	GLY261
B	ARG285
B	LYS286
B	GLY437
B	ASP438
B	GLU453
B	HIS454
B	HIS455
B	ALA458
B	PHE482
B	TRP483
B	HOH2009
B	HOH2012
B	HOH2013
B	HOH2014
B	HOH2044
B	HOH2145
B	HOH2146
B	HOH2184
B	HOH2291
B	HOH2342
B	TRS7000

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TRS B 7000

Chain	Residue
B	GLU164
B	LYS232
B	THR263
B	ASN403
B	GLU405
B	FAD1000
B	HOH2149
B	HOH2286
B	HOH2445

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TRS B 7001

Chain	Residue
B	THR328
B	GLU329
B	VAL330
B	GLY360
B	THR470
B	HOH2025
B	HOH2236
B	HOH2446

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	698
Details	Region: {"description":"FAD-dependent oxidoreductase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22103349","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---