5FPH

The GTPase domains of the immunity-related Irga6 dimerize in a parallel head-to-head fashion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000166	molecular_function	nucleotide binding
A	0002376	biological_process	immune system process
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0009617	biological_process	response to bacterium
A	0010506	biological_process	regulation of autophagy
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0020005	cellular_component	symbiont-containing vacuole membrane
A	0031965	cellular_component	nuclear membrane
A	0032580	cellular_component	Golgi cisterna membrane
A	0035458	biological_process	cellular response to interferon-beta
A	0042802	molecular_function	identical protein binding
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0050829	biological_process	defense response to Gram-negative bacterium
B	0000045	biological_process	autophagosome assembly
B	0000166	molecular_function	nucleotide binding
B	0002376	biological_process	immune system process
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0009617	biological_process	response to bacterium
B	0010506	biological_process	regulation of autophagy
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0019003	molecular_function	GDP binding
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0020005	cellular_component	symbiont-containing vacuole membrane
B	0031965	cellular_component	nuclear membrane
B	0032580	cellular_component	Golgi cisterna membrane
B	0035458	biological_process	cellular response to interferon-beta
B	0042802	molecular_function	identical protein binding
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0050829	biological_process	defense response to Gram-negative bacterium
C	0000045	biological_process	autophagosome assembly
C	0000166	molecular_function	nucleotide binding
C	0002376	biological_process	immune system process
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0009617	biological_process	response to bacterium
C	0010506	biological_process	regulation of autophagy
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0019003	molecular_function	GDP binding
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0020005	cellular_component	symbiont-containing vacuole membrane
C	0031965	cellular_component	nuclear membrane
C	0032580	cellular_component	Golgi cisterna membrane
C	0035458	biological_process	cellular response to interferon-beta
C	0042802	molecular_function	identical protein binding
C	0042832	biological_process	defense response to protozoan
C	0045087	biological_process	innate immune response
C	0050829	biological_process	defense response to Gram-negative bacterium
D	0000045	biological_process	autophagosome assembly
D	0000166	molecular_function	nucleotide binding
D	0002376	biological_process	immune system process
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0009617	biological_process	response to bacterium
D	0010506	biological_process	regulation of autophagy
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0019003	molecular_function	GDP binding
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0020005	cellular_component	symbiont-containing vacuole membrane
D	0031965	cellular_component	nuclear membrane
D	0032580	cellular_component	Golgi cisterna membrane
D	0035458	biological_process	cellular response to interferon-beta
D	0042802	molecular_function	identical protein binding
D	0042832	biological_process	defense response to protozoan
D	0045087	biological_process	innate immune response
D	0050829	biological_process	defense response to Gram-negative bacterium
E	0000045	biological_process	autophagosome assembly
E	0000166	molecular_function	nucleotide binding
E	0002376	biological_process	immune system process
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0009617	biological_process	response to bacterium
E	0010506	biological_process	regulation of autophagy
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0019003	molecular_function	GDP binding
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0020005	cellular_component	symbiont-containing vacuole membrane
E	0031965	cellular_component	nuclear membrane
E	0032580	cellular_component	Golgi cisterna membrane
E	0035458	biological_process	cellular response to interferon-beta
E	0042802	molecular_function	identical protein binding
E	0042832	biological_process	defense response to protozoan
E	0045087	biological_process	innate immune response
E	0050829	biological_process	defense response to Gram-negative bacterium
F	0000045	biological_process	autophagosome assembly
F	0000166	molecular_function	nucleotide binding
F	0002376	biological_process	immune system process
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0009617	biological_process	response to bacterium
F	0010506	biological_process	regulation of autophagy
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0019003	molecular_function	GDP binding
F	0019221	biological_process	cytokine-mediated signaling pathway
F	0020005	cellular_component	symbiont-containing vacuole membrane
F	0031965	cellular_component	nuclear membrane
F	0032580	cellular_component	Golgi cisterna membrane
F	0035458	biological_process	cellular response to interferon-beta
F	0042802	molecular_function	identical protein binding
F	0042832	biological_process	defense response to protozoan
F	0045087	biological_process	innate immune response
F	0050829	biological_process	defense response to Gram-negative bacterium
G	0000045	biological_process	autophagosome assembly
G	0000166	molecular_function	nucleotide binding
G	0002376	biological_process	immune system process
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0009617	biological_process	response to bacterium
G	0010506	biological_process	regulation of autophagy
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0019003	molecular_function	GDP binding
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0020005	cellular_component	symbiont-containing vacuole membrane
G	0031965	cellular_component	nuclear membrane
G	0032580	cellular_component	Golgi cisterna membrane
G	0035458	biological_process	cellular response to interferon-beta
G	0042802	molecular_function	identical protein binding
G	0042832	biological_process	defense response to protozoan
G	0045087	biological_process	innate immune response
G	0050829	biological_process	defense response to Gram-negative bacterium

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP A 501

Chain	Residue
A	THR78
A	GLY103
A	VAL104
A	VAL105
A	LYS184
A	ASP186
A	SER231
A	ASN232
A	LYS233
A	MG502
A	GLY79
A	SER80
A	GLY81
A	LYS82
A	SER83
A	SER84
A	THR102
A	GLY103

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	SER83
A	GLU106
A	ASP126
A	GNP501

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GNP B 501

Chain	Residue
B	THR78
B	GLY79
B	SER80
B	GLY81
B	LYS82
B	SER83
B	SER84
B	THR102
B	VAL104
B	ASP126
B	LYS184
B	ASP186
B	SER231
B	ASN232
B	LYS233
B	MG502

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 502

Chain	Residue
B	LYS82
B	SER83
B	ASP126
B	GNP501

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP C 501

Chain	Residue
C	THR78
C	GLY79
C	SER80
C	GLY81
C	LYS82
C	SER83
C	SER84
C	THR102
C	GLY103
C	VAL105
C	ASP126
C	LYS184
C	ASP186
C	SER231
C	ASN232
C	LYS233
C	MG502
C	TRS504

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 502

Chain	Residue
C	SER83
C	LYS101
C	ASP126
C	GNP501

---

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GNP E 501

Chain	Residue
E	GLU77
E	GLY79
E	SER80
E	GLY81
E	LYS82
E	SER83
E	SER84
E	THR102
E	VAL104
E	ASP126
E	LYS184
E	ASP186
E	SER231
E	ASN232
E	LYS233
E	MG502
E	TRS504

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 502

Chain	Residue
E	SER83
E	ASP126
E	GNP501

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP F 501

Chain	Residue
F	ASN232
F	LYS233
F	MG502
F	GLU77
F	THR78
F	GLY79
F	SER80
F	GLY81
F	LYS82
F	SER83
F	SER84
F	THR102
F	GLY103
F	ASP126
F	LYS184
F	ASP186
F	SER187
F	SER231

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG F 502

Chain	Residue
F	SER83
F	ASP126
F	GNP501

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GNP G 501

Chain	Residue
G	THR78
G	GLY79
G	SER80
G	GLY81
G	LYS82
G	SER83
G	SER84
G	THR102
G	VAL104
G	LYS184
G	ASP186
G	ASN232
G	LYS233
G	MG502

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG G 502

Chain	Residue
G	SER83
G	ASP126
G	GNP501

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 503

Chain	Residue
F	ASP150
F	GLU176
F	GLU177
F	HOH602

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 501

Chain	Residue
D	ASP150
D	GLU176
D	GLU177

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 503

Chain	Residue
B	ASP150
B	GLU176
B	GLU177
B	HOH602

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 503

Chain	Residue
A	ASP150
A	GLU176
A	GLU177

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 503

Chain	Residue
E	ASP150
E	GLU176
E	GLU177

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG G 503

Chain	Residue
G	ASP150
G	GLU176
G	GLU177

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 503

Chain	Residue
C	ASP150
C	GLU176
C	GLU177

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TRS C 504

Chain	Residue
B	LYS196
C	THR102
C	GLY103
C	GNP501

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TRS E 504

Chain	Residue
D	LYS162
D	ASN163
E	THR102
E	GNP501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Modified residue: {"description":"(Microbial infection) Phosphothreonine; by ROP18","evidences":[{"source":"PubMed","id":"21203588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---