Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FMW

The poly-C9 component of the Complement Membrane Attack Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001906	biological_process	cell killing
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005579	cellular_component	membrane attack complex
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0006956	biological_process	complement activation
A	0006957	biological_process	complement activation, alternative pathway
A	0006958	biological_process	complement activation, classical pathway
A	0016020	cellular_component	membrane
A	0031640	biological_process	killing of cells of another organism
A	0044218	cellular_component	other organism cell membrane
A	0050778	biological_process	positive regulation of immune response
A	0051260	biological_process	protein homooligomerization
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
B	0001906	biological_process	cell killing
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005579	cellular_component	membrane attack complex
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006955	biological_process	immune response
B	0006956	biological_process	complement activation
B	0006957	biological_process	complement activation, alternative pathway
B	0006958	biological_process	complement activation, classical pathway
B	0016020	cellular_component	membrane
B	0031640	biological_process	killing of cells of another organism
B	0044218	cellular_component	other organism cell membrane
B	0050778	biological_process	positive regulation of immune response
B	0051260	biological_process	protein homooligomerization
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
C	0001906	biological_process	cell killing
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005579	cellular_component	membrane attack complex
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0006956	biological_process	complement activation
C	0006957	biological_process	complement activation, alternative pathway
C	0006958	biological_process	complement activation, classical pathway
C	0016020	cellular_component	membrane
C	0031640	biological_process	killing of cells of another organism
C	0044218	cellular_component	other organism cell membrane
C	0050778	biological_process	positive regulation of immune response
C	0051260	biological_process	protein homooligomerization
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
D	0001906	biological_process	cell killing
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005579	cellular_component	membrane attack complex
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0006956	biological_process	complement activation
D	0006957	biological_process	complement activation, alternative pathway
D	0006958	biological_process	complement activation, classical pathway
D	0016020	cellular_component	membrane
D	0031640	biological_process	killing of cells of another organism
D	0044218	cellular_component	other organism cell membrane
D	0050778	biological_process	positive regulation of immune response
D	0051260	biological_process	protein homooligomerization
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
E	0001906	biological_process	cell killing
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005579	cellular_component	membrane attack complex
E	0005615	cellular_component	extracellular space
E	0005886	cellular_component	plasma membrane
E	0006955	biological_process	immune response
E	0006956	biological_process	complement activation
E	0006957	biological_process	complement activation, alternative pathway
E	0006958	biological_process	complement activation, classical pathway
E	0016020	cellular_component	membrane
E	0031640	biological_process	killing of cells of another organism
E	0044218	cellular_component	other organism cell membrane
E	0050778	biological_process	positive regulation of immune response
E	0051260	biological_process	protein homooligomerization
E	0070062	cellular_component	extracellular exosome
E	0072562	cellular_component	blood microparticle
F	0001906	biological_process	cell killing
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005579	cellular_component	membrane attack complex
F	0005615	cellular_component	extracellular space
F	0005886	cellular_component	plasma membrane
F	0006955	biological_process	immune response
F	0006956	biological_process	complement activation
F	0006957	biological_process	complement activation, alternative pathway
F	0006958	biological_process	complement activation, classical pathway
F	0016020	cellular_component	membrane
F	0031640	biological_process	killing of cells of another organism
F	0044218	cellular_component	other organism cell membrane
F	0050778	biological_process	positive regulation of immune response
F	0051260	biological_process	protein homooligomerization
F	0070062	cellular_component	extracellular exosome
F	0072562	cellular_component	blood microparticle
G	0001906	biological_process	cell killing
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005579	cellular_component	membrane attack complex
G	0005615	cellular_component	extracellular space
G	0005886	cellular_component	plasma membrane
G	0006955	biological_process	immune response
G	0006956	biological_process	complement activation
G	0006957	biological_process	complement activation, alternative pathway
G	0006958	biological_process	complement activation, classical pathway
G	0016020	cellular_component	membrane
G	0031640	biological_process	killing of cells of another organism
G	0044218	cellular_component	other organism cell membrane
G	0050778	biological_process	positive regulation of immune response
G	0051260	biological_process	protein homooligomerization
G	0070062	cellular_component	extracellular exosome
G	0072562	cellular_component	blood microparticle
H	0001906	biological_process	cell killing
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005579	cellular_component	membrane attack complex
H	0005615	cellular_component	extracellular space
H	0005886	cellular_component	plasma membrane
H	0006955	biological_process	immune response
H	0006956	biological_process	complement activation
H	0006957	biological_process	complement activation, alternative pathway
H	0006958	biological_process	complement activation, classical pathway
H	0016020	cellular_component	membrane
H	0031640	biological_process	killing of cells of another organism
H	0044218	cellular_component	other organism cell membrane
H	0050778	biological_process	positive regulation of immune response
H	0051260	biological_process	protein homooligomerization
H	0070062	cellular_component	extracellular exosome
H	0072562	cellular_component	blood microparticle
I	0001906	biological_process	cell killing
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005579	cellular_component	membrane attack complex
I	0005615	cellular_component	extracellular space
I	0005886	cellular_component	plasma membrane
I	0006955	biological_process	immune response
I	0006956	biological_process	complement activation
I	0006957	biological_process	complement activation, alternative pathway
I	0006958	biological_process	complement activation, classical pathway
I	0016020	cellular_component	membrane
I	0031640	biological_process	killing of cells of another organism
I	0044218	cellular_component	other organism cell membrane
I	0050778	biological_process	positive regulation of immune response
I	0051260	biological_process	protein homooligomerization
I	0070062	cellular_component	extracellular exosome
I	0072562	cellular_component	blood microparticle
J	0001906	biological_process	cell killing
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005579	cellular_component	membrane attack complex
J	0005615	cellular_component	extracellular space
J	0005886	cellular_component	plasma membrane
J	0006955	biological_process	immune response
J	0006956	biological_process	complement activation
J	0006957	biological_process	complement activation, alternative pathway
J	0006958	biological_process	complement activation, classical pathway
J	0016020	cellular_component	membrane
J	0031640	biological_process	killing of cells of another organism
J	0044218	cellular_component	other organism cell membrane
J	0050778	biological_process	positive regulation of immune response
J	0051260	biological_process	protein homooligomerization
J	0070062	cellular_component	extracellular exosome
J	0072562	cellular_component	blood microparticle
K	0001906	biological_process	cell killing
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005579	cellular_component	membrane attack complex
K	0005615	cellular_component	extracellular space
K	0005886	cellular_component	plasma membrane
K	0006955	biological_process	immune response
K	0006956	biological_process	complement activation
K	0006957	biological_process	complement activation, alternative pathway
K	0006958	biological_process	complement activation, classical pathway
K	0016020	cellular_component	membrane
K	0031640	biological_process	killing of cells of another organism
K	0044218	cellular_component	other organism cell membrane
K	0050778	biological_process	positive regulation of immune response
K	0051260	biological_process	protein homooligomerization
K	0070062	cellular_component	extracellular exosome
K	0072562	cellular_component	blood microparticle
L	0001906	biological_process	cell killing
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005579	cellular_component	membrane attack complex
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0006956	biological_process	complement activation
L	0006957	biological_process	complement activation, alternative pathway
L	0006958	biological_process	complement activation, classical pathway
L	0016020	cellular_component	membrane
L	0031640	biological_process	killing of cells of another organism
L	0044218	cellular_component	other organism cell membrane
L	0050778	biological_process	positive regulation of immune response
L	0051260	biological_process	protein homooligomerization
L	0070062	cellular_component	extracellular exosome
L	0072562	cellular_component	blood microparticle
M	0001906	biological_process	cell killing
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005579	cellular_component	membrane attack complex
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0006955	biological_process	immune response
M	0006956	biological_process	complement activation
M	0006957	biological_process	complement activation, alternative pathway
M	0006958	biological_process	complement activation, classical pathway
M	0016020	cellular_component	membrane
M	0031640	biological_process	killing of cells of another organism
M	0044218	cellular_component	other organism cell membrane
M	0050778	biological_process	positive regulation of immune response
M	0051260	biological_process	protein homooligomerization
M	0070062	cellular_component	extracellular exosome
M	0072562	cellular_component	blood microparticle
N	0001906	biological_process	cell killing
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005579	cellular_component	membrane attack complex
N	0005615	cellular_component	extracellular space
N	0005886	cellular_component	plasma membrane
N	0006955	biological_process	immune response
N	0006956	biological_process	complement activation
N	0006957	biological_process	complement activation, alternative pathway
N	0006958	biological_process	complement activation, classical pathway
N	0016020	cellular_component	membrane
N	0031640	biological_process	killing of cells of another organism
N	0044218	cellular_component	other organism cell membrane
N	0050778	biological_process	positive regulation of immune response
N	0051260	biological_process	protein homooligomerization
N	0070062	cellular_component	extracellular exosome
N	0072562	cellular_component	blood microparticle
O	0001906	biological_process	cell killing
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005579	cellular_component	membrane attack complex
O	0005615	cellular_component	extracellular space
O	0005886	cellular_component	plasma membrane
O	0006955	biological_process	immune response
O	0006956	biological_process	complement activation
O	0006957	biological_process	complement activation, alternative pathway
O	0006958	biological_process	complement activation, classical pathway
O	0016020	cellular_component	membrane
O	0031640	biological_process	killing of cells of another organism
O	0044218	cellular_component	other organism cell membrane
O	0050778	biological_process	positive regulation of immune response
O	0051260	biological_process	protein homooligomerization
O	0070062	cellular_component	extracellular exosome
O	0072562	cellular_component	blood microparticle
P	0001906	biological_process	cell killing
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005579	cellular_component	membrane attack complex
P	0005615	cellular_component	extracellular space
P	0005886	cellular_component	plasma membrane
P	0006955	biological_process	immune response
P	0006956	biological_process	complement activation
P	0006957	biological_process	complement activation, alternative pathway
P	0006958	biological_process	complement activation, classical pathway
P	0016020	cellular_component	membrane
P	0031640	biological_process	killing of cells of another organism
P	0044218	cellular_component	other organism cell membrane
P	0050778	biological_process	positive regulation of immune response
P	0051260	biological_process	protein homooligomerization
P	0070062	cellular_component	extracellular exosome
P	0072562	cellular_component	blood microparticle
Q	0001906	biological_process	cell killing
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005579	cellular_component	membrane attack complex
Q	0005615	cellular_component	extracellular space
Q	0005886	cellular_component	plasma membrane
Q	0006955	biological_process	immune response
Q	0006956	biological_process	complement activation
Q	0006957	biological_process	complement activation, alternative pathway
Q	0006958	biological_process	complement activation, classical pathway
Q	0016020	cellular_component	membrane
Q	0031640	biological_process	killing of cells of another organism
Q	0044218	cellular_component	other organism cell membrane
Q	0050778	biological_process	positive regulation of immune response
Q	0051260	biological_process	protein homooligomerization
Q	0070062	cellular_component	extracellular exosome
Q	0072562	cellular_component	blood microparticle
R	0001906	biological_process	cell killing
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005579	cellular_component	membrane attack complex
R	0005615	cellular_component	extracellular space
R	0005886	cellular_component	plasma membrane
R	0006955	biological_process	immune response
R	0006956	biological_process	complement activation
R	0006957	biological_process	complement activation, alternative pathway
R	0006958	biological_process	complement activation, classical pathway
R	0016020	cellular_component	membrane
R	0031640	biological_process	killing of cells of another organism
R	0044218	cellular_component	other organism cell membrane
R	0050778	biological_process	positive regulation of immune response
R	0051260	biological_process	protein homooligomerization
R	0070062	cellular_component	extracellular exosome
R	0072562	cellular_component	blood microparticle
S	0001906	biological_process	cell killing
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005579	cellular_component	membrane attack complex
S	0005615	cellular_component	extracellular space
S	0005886	cellular_component	plasma membrane
S	0006955	biological_process	immune response
S	0006956	biological_process	complement activation
S	0006957	biological_process	complement activation, alternative pathway
S	0006958	biological_process	complement activation, classical pathway
S	0016020	cellular_component	membrane
S	0031640	biological_process	killing of cells of another organism
S	0044218	cellular_component	other organism cell membrane
S	0050778	biological_process	positive regulation of immune response
S	0051260	biological_process	protein homooligomerization
S	0070062	cellular_component	extracellular exosome
S	0072562	cellular_component	blood microparticle
T	0001906	biological_process	cell killing
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005579	cellular_component	membrane attack complex
T	0005615	cellular_component	extracellular space
T	0005886	cellular_component	plasma membrane
T	0006955	biological_process	immune response
T	0006956	biological_process	complement activation
T	0006957	biological_process	complement activation, alternative pathway
T	0006958	biological_process	complement activation, classical pathway
T	0016020	cellular_component	membrane
T	0031640	biological_process	killing of cells of another organism
T	0044218	cellular_component	other organism cell membrane
T	0050778	biological_process	positive regulation of immune response
T	0051260	biological_process	protein homooligomerization
T	0070062	cellular_component	extracellular exosome
T	0072562	cellular_component	blood microparticle
U	0001906	biological_process	cell killing
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005579	cellular_component	membrane attack complex
U	0005615	cellular_component	extracellular space
U	0005886	cellular_component	plasma membrane
U	0006955	biological_process	immune response
U	0006956	biological_process	complement activation
U	0006957	biological_process	complement activation, alternative pathway
U	0006958	biological_process	complement activation, classical pathway
U	0016020	cellular_component	membrane
U	0031640	biological_process	killing of cells of another organism
U	0044218	cellular_component	other organism cell membrane
U	0050778	biological_process	positive regulation of immune response
U	0051260	biological_process	protein homooligomerization
U	0070062	cellular_component	extracellular exosome
U	0072562	cellular_component	blood microparticle
V	0001906	biological_process	cell killing
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005579	cellular_component	membrane attack complex
V	0005615	cellular_component	extracellular space
V	0005886	cellular_component	plasma membrane
V	0006955	biological_process	immune response
V	0006956	biological_process	complement activation
V	0006957	biological_process	complement activation, alternative pathway
V	0006958	biological_process	complement activation, classical pathway
V	0016020	cellular_component	membrane
V	0031640	biological_process	killing of cells of another organism
V	0044218	cellular_component	other organism cell membrane
V	0050778	biological_process	positive regulation of immune response
V	0051260	biological_process	protein homooligomerization
V	0070062	cellular_component	extracellular exosome
V	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CaCpfKfeGIaC

Chain	Residue	Details
A	CYS507-CYS518

site_id	PS00279
Number of Residues	12
Details	MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YfafletYGTHY

Chain	Residue	Details
A	TYR314-TYR325

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. ClCacPFkfegia..C

Chain	Residue	Details
A	CYS505-CYS518

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIkmrlr.CNgdnDCgdfsDEDd....C

Chain	Residue	Details
A	CYS91-CYS113

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	770
Details	TRANSMEM: Beta stranded => ECO:0000255

Chain	Residue	Details
A	VAL293-TYR309
E	TYR314-GLY333
F	VAL293-TYR309
F	TYR314-GLY333
G	VAL293-TYR309
G	TYR314-GLY333
H	VAL293-TYR309
H	TYR314-GLY333
I	VAL293-TYR309
I	TYR314-GLY333
J	VAL293-TYR309
A	TYR314-GLY333
J	TYR314-GLY333
K	VAL293-TYR309
K	TYR314-GLY333
L	VAL293-TYR309
L	TYR314-GLY333
M	VAL293-TYR309
M	TYR314-GLY333
N	VAL293-TYR309
N	TYR314-GLY333
O	VAL293-TYR309
B	VAL293-TYR309
O	TYR314-GLY333
P	VAL293-TYR309
P	TYR314-GLY333
Q	VAL293-TYR309
Q	TYR314-GLY333
R	VAL293-TYR309
R	TYR314-GLY333
S	VAL293-TYR309
S	TYR314-GLY333
T	VAL293-TYR309
B	TYR314-GLY333
T	TYR314-GLY333
U	VAL293-TYR309
U	TYR314-GLY333
V	VAL293-TYR309
V	TYR314-GLY333
C	VAL293-TYR309
C	TYR314-GLY333
D	VAL293-TYR309
D	TYR314-GLY333
E	VAL293-TYR309

site_id	SWS_FT_FI2
Number of Residues	22
Details	SITE: Cleavage; by thrombin

Chain	Residue	Details
A	HIS244
J	HIS244
K	HIS244
L	HIS244
M	HIS244
N	HIS244
O	HIS244
P	HIS244
Q	HIS244
R	HIS244
S	HIS244
B	HIS244
T	HIS244
U	HIS244
V	HIS244
C	HIS244
D	HIS244
E	HIS244
F	HIS244
G	HIS244
H	HIS244
I	HIS244

site_id	SWS_FT_FI3
Number of Residues	22
Details	CARBOHYD: C-linked (Man) tryptophan => ECO:0000269\|PubMed:10551839

Chain	Residue	Details
A	TRP27
J	TRP27
K	TRP27
L	TRP27
M	TRP27
N	TRP27
O	TRP27
P	TRP27
Q	TRP27
R	TRP27
S	TRP27
B	TRP27
T	TRP27
U	TRP27
V	TRP27
C	TRP27
D	TRP27
E	TRP27
F	TRP27
G	TRP27
H	TRP27
I	TRP27

site_id	SWS_FT_FI4
Number of Residues	22
Details	CARBOHYD: C-linked (Man) tryptophan; partial => ECO:0000269\|PubMed:10551839

Chain	Residue	Details
A	TRP30
J	TRP30
K	TRP30
L	TRP30
M	TRP30
N	TRP30
O	TRP30
P	TRP30
Q	TRP30
R	TRP30
S	TRP30
B	TRP30
T	TRP30
U	TRP30
V	TRP30
C	TRP30
D	TRP30
E	TRP30
F	TRP30
G	TRP30
H	TRP30
I	TRP30

site_id	SWS_FT_FI5
Number of Residues	22
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:4055801

Chain	Residue	Details
A	ASN256
J	ASN256
K	ASN256
L	ASN256
M	ASN256
N	ASN256
O	ASN256
P	ASN256
Q	ASN256
R	ASN256
S	ASN256
B	ASN256
T	ASN256
U	ASN256
V	ASN256
C	ASN256
D	ASN256
E	ASN256
F	ASN256
G	ASN256
H	ASN256
I	ASN256

site_id	SWS_FT_FI6
Number of Residues	22
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:14760718, ECO:0000269\|PubMed:16263699, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19139490, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:4055801

Chain	Residue	Details
A	ASN394
J	ASN394
K	ASN394
L	ASN394
M	ASN394
N	ASN394
O	ASN394
P	ASN394
Q	ASN394
R	ASN394
S	ASN394
B	ASN394
T	ASN394
U	ASN394
V	ASN394
C	ASN394
D	ASN394
E	ASN394
F	ASN394
G	ASN394
H	ASN394
I	ASN394

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)