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5FMW

The poly-C9 component of the Complement Membrane Attack Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001906biological_processcell killing
A0002376biological_processimmune system process
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005579cellular_componentmembrane attack complex
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0006958biological_processcomplement activation, classical pathway
A0022829molecular_functionwide pore channel activity
A0031640biological_processkilling of cells of another organism
A0044218cellular_componentother organism cell membrane
A0045087biological_processinnate immune response
A0050778biological_processpositive regulation of immune response
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0072562cellular_componentblood microparticle
A0160257biological_processcomplement activation, GZMK pathway
B0001906biological_processcell killing
B0002376biological_processimmune system process
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005579cellular_componentmembrane attack complex
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006955biological_processimmune response
B0006956biological_processcomplement activation
B0006957biological_processcomplement activation, alternative pathway
B0006958biological_processcomplement activation, classical pathway
B0022829molecular_functionwide pore channel activity
B0031640biological_processkilling of cells of another organism
B0044218cellular_componentother organism cell membrane
B0045087biological_processinnate immune response
B0050778biological_processpositive regulation of immune response
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0072562cellular_componentblood microparticle
B0160257biological_processcomplement activation, GZMK pathway
C0001906biological_processcell killing
C0002376biological_processimmune system process
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005579cellular_componentmembrane attack complex
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0006956biological_processcomplement activation
C0006957biological_processcomplement activation, alternative pathway
C0006958biological_processcomplement activation, classical pathway
C0022829molecular_functionwide pore channel activity
C0031640biological_processkilling of cells of another organism
C0044218cellular_componentother organism cell membrane
C0045087biological_processinnate immune response
C0050778biological_processpositive regulation of immune response
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0072562cellular_componentblood microparticle
C0160257biological_processcomplement activation, GZMK pathway
D0001906biological_processcell killing
D0002376biological_processimmune system process
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005579cellular_componentmembrane attack complex
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0006958biological_processcomplement activation, classical pathway
D0022829molecular_functionwide pore channel activity
D0031640biological_processkilling of cells of another organism
D0044218cellular_componentother organism cell membrane
D0045087biological_processinnate immune response
D0050778biological_processpositive regulation of immune response
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0070062cellular_componentextracellular exosome
D0072562cellular_componentblood microparticle
D0160257biological_processcomplement activation, GZMK pathway
E0001906biological_processcell killing
E0002376biological_processimmune system process
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005579cellular_componentmembrane attack complex
E0005615cellular_componentextracellular space
E0005886cellular_componentplasma membrane
E0006955biological_processimmune response
E0006956biological_processcomplement activation
E0006957biological_processcomplement activation, alternative pathway
E0006958biological_processcomplement activation, classical pathway
E0022829molecular_functionwide pore channel activity
E0031640biological_processkilling of cells of another organism
E0044218cellular_componentother organism cell membrane
E0045087biological_processinnate immune response
E0050778biological_processpositive regulation of immune response
E0051260biological_processprotein homooligomerization
E0055085biological_processtransmembrane transport
E0070062cellular_componentextracellular exosome
E0072562cellular_componentblood microparticle
E0160257biological_processcomplement activation, GZMK pathway
F0001906biological_processcell killing
F0002376biological_processimmune system process
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005579cellular_componentmembrane attack complex
F0005615cellular_componentextracellular space
F0005886cellular_componentplasma membrane
F0006955biological_processimmune response
F0006956biological_processcomplement activation
F0006957biological_processcomplement activation, alternative pathway
F0006958biological_processcomplement activation, classical pathway
F0022829molecular_functionwide pore channel activity
F0031640biological_processkilling of cells of another organism
F0044218cellular_componentother organism cell membrane
F0045087biological_processinnate immune response
F0050778biological_processpositive regulation of immune response
F0051260biological_processprotein homooligomerization
F0055085biological_processtransmembrane transport
F0070062cellular_componentextracellular exosome
F0072562cellular_componentblood microparticle
F0160257biological_processcomplement activation, GZMK pathway
G0001906biological_processcell killing
G0002376biological_processimmune system process
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005579cellular_componentmembrane attack complex
G0005615cellular_componentextracellular space
G0005886cellular_componentplasma membrane
G0006955biological_processimmune response
G0006956biological_processcomplement activation
G0006957biological_processcomplement activation, alternative pathway
G0006958biological_processcomplement activation, classical pathway
G0022829molecular_functionwide pore channel activity
G0031640biological_processkilling of cells of another organism
G0044218cellular_componentother organism cell membrane
G0045087biological_processinnate immune response
G0050778biological_processpositive regulation of immune response
G0051260biological_processprotein homooligomerization
G0055085biological_processtransmembrane transport
G0070062cellular_componentextracellular exosome
G0072562cellular_componentblood microparticle
G0160257biological_processcomplement activation, GZMK pathway
H0001906biological_processcell killing
H0002376biological_processimmune system process
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005579cellular_componentmembrane attack complex
H0005615cellular_componentextracellular space
H0005886cellular_componentplasma membrane
H0006955biological_processimmune response
H0006956biological_processcomplement activation
H0006957biological_processcomplement activation, alternative pathway
H0006958biological_processcomplement activation, classical pathway
H0022829molecular_functionwide pore channel activity
H0031640biological_processkilling of cells of another organism
H0044218cellular_componentother organism cell membrane
H0045087biological_processinnate immune response
H0050778biological_processpositive regulation of immune response
H0051260biological_processprotein homooligomerization
H0055085biological_processtransmembrane transport
H0070062cellular_componentextracellular exosome
H0072562cellular_componentblood microparticle
H0160257biological_processcomplement activation, GZMK pathway
I0001906biological_processcell killing
I0002376biological_processimmune system process
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005579cellular_componentmembrane attack complex
I0005615cellular_componentextracellular space
I0005886cellular_componentplasma membrane
I0006955biological_processimmune response
I0006956biological_processcomplement activation
I0006957biological_processcomplement activation, alternative pathway
I0006958biological_processcomplement activation, classical pathway
I0022829molecular_functionwide pore channel activity
I0031640biological_processkilling of cells of another organism
I0044218cellular_componentother organism cell membrane
I0045087biological_processinnate immune response
I0050778biological_processpositive regulation of immune response
I0051260biological_processprotein homooligomerization
I0055085biological_processtransmembrane transport
I0070062cellular_componentextracellular exosome
I0072562cellular_componentblood microparticle
I0160257biological_processcomplement activation, GZMK pathway
J0001906biological_processcell killing
J0002376biological_processimmune system process
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005579cellular_componentmembrane attack complex
J0005615cellular_componentextracellular space
J0005886cellular_componentplasma membrane
J0006955biological_processimmune response
J0006956biological_processcomplement activation
J0006957biological_processcomplement activation, alternative pathway
J0006958biological_processcomplement activation, classical pathway
J0022829molecular_functionwide pore channel activity
J0031640biological_processkilling of cells of another organism
J0044218cellular_componentother organism cell membrane
J0045087biological_processinnate immune response
J0050778biological_processpositive regulation of immune response
J0051260biological_processprotein homooligomerization
J0055085biological_processtransmembrane transport
J0070062cellular_componentextracellular exosome
J0072562cellular_componentblood microparticle
J0160257biological_processcomplement activation, GZMK pathway
K0001906biological_processcell killing
K0002376biological_processimmune system process
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005579cellular_componentmembrane attack complex
K0005615cellular_componentextracellular space
K0005886cellular_componentplasma membrane
K0006955biological_processimmune response
K0006956biological_processcomplement activation
K0006957biological_processcomplement activation, alternative pathway
K0006958biological_processcomplement activation, classical pathway
K0022829molecular_functionwide pore channel activity
K0031640biological_processkilling of cells of another organism
K0044218cellular_componentother organism cell membrane
K0045087biological_processinnate immune response
K0050778biological_processpositive regulation of immune response
K0051260biological_processprotein homooligomerization
K0055085biological_processtransmembrane transport
K0070062cellular_componentextracellular exosome
K0072562cellular_componentblood microparticle
K0160257biological_processcomplement activation, GZMK pathway
L0001906biological_processcell killing
L0002376biological_processimmune system process
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005579cellular_componentmembrane attack complex
L0005615cellular_componentextracellular space
L0005886cellular_componentplasma membrane
L0006955biological_processimmune response
L0006956biological_processcomplement activation
L0006957biological_processcomplement activation, alternative pathway
L0006958biological_processcomplement activation, classical pathway
L0022829molecular_functionwide pore channel activity
L0031640biological_processkilling of cells of another organism
L0044218cellular_componentother organism cell membrane
L0045087biological_processinnate immune response
L0050778biological_processpositive regulation of immune response
L0051260biological_processprotein homooligomerization
L0055085biological_processtransmembrane transport
L0070062cellular_componentextracellular exosome
L0072562cellular_componentblood microparticle
L0160257biological_processcomplement activation, GZMK pathway
M0001906biological_processcell killing
M0002376biological_processimmune system process
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005579cellular_componentmembrane attack complex
M0005615cellular_componentextracellular space
M0005886cellular_componentplasma membrane
M0006955biological_processimmune response
M0006956biological_processcomplement activation
M0006957biological_processcomplement activation, alternative pathway
M0006958biological_processcomplement activation, classical pathway
M0022829molecular_functionwide pore channel activity
M0031640biological_processkilling of cells of another organism
M0044218cellular_componentother organism cell membrane
M0045087biological_processinnate immune response
M0050778biological_processpositive regulation of immune response
M0051260biological_processprotein homooligomerization
M0055085biological_processtransmembrane transport
M0070062cellular_componentextracellular exosome
M0072562cellular_componentblood microparticle
M0160257biological_processcomplement activation, GZMK pathway
N0001906biological_processcell killing
N0002376biological_processimmune system process
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005579cellular_componentmembrane attack complex
N0005615cellular_componentextracellular space
N0005886cellular_componentplasma membrane
N0006955biological_processimmune response
N0006956biological_processcomplement activation
N0006957biological_processcomplement activation, alternative pathway
N0006958biological_processcomplement activation, classical pathway
N0022829molecular_functionwide pore channel activity
N0031640biological_processkilling of cells of another organism
N0044218cellular_componentother organism cell membrane
N0045087biological_processinnate immune response
N0050778biological_processpositive regulation of immune response
N0051260biological_processprotein homooligomerization
N0055085biological_processtransmembrane transport
N0070062cellular_componentextracellular exosome
N0072562cellular_componentblood microparticle
N0160257biological_processcomplement activation, GZMK pathway
O0001906biological_processcell killing
O0002376biological_processimmune system process
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005579cellular_componentmembrane attack complex
O0005615cellular_componentextracellular space
O0005886cellular_componentplasma membrane
O0006955biological_processimmune response
O0006956biological_processcomplement activation
O0006957biological_processcomplement activation, alternative pathway
O0006958biological_processcomplement activation, classical pathway
O0022829molecular_functionwide pore channel activity
O0031640biological_processkilling of cells of another organism
O0044218cellular_componentother organism cell membrane
O0045087biological_processinnate immune response
O0050778biological_processpositive regulation of immune response
O0051260biological_processprotein homooligomerization
O0055085biological_processtransmembrane transport
O0070062cellular_componentextracellular exosome
O0072562cellular_componentblood microparticle
O0160257biological_processcomplement activation, GZMK pathway
P0001906biological_processcell killing
P0002376biological_processimmune system process
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005579cellular_componentmembrane attack complex
P0005615cellular_componentextracellular space
P0005886cellular_componentplasma membrane
P0006955biological_processimmune response
P0006956biological_processcomplement activation
P0006957biological_processcomplement activation, alternative pathway
P0006958biological_processcomplement activation, classical pathway
P0022829molecular_functionwide pore channel activity
P0031640biological_processkilling of cells of another organism
P0044218cellular_componentother organism cell membrane
P0045087biological_processinnate immune response
P0050778biological_processpositive regulation of immune response
P0051260biological_processprotein homooligomerization
P0055085biological_processtransmembrane transport
P0070062cellular_componentextracellular exosome
P0072562cellular_componentblood microparticle
P0160257biological_processcomplement activation, GZMK pathway
Q0001906biological_processcell killing
Q0002376biological_processimmune system process
Q0005515molecular_functionprotein binding
Q0005576cellular_componentextracellular region
Q0005579cellular_componentmembrane attack complex
Q0005615cellular_componentextracellular space
Q0005886cellular_componentplasma membrane
Q0006955biological_processimmune response
Q0006956biological_processcomplement activation
Q0006957biological_processcomplement activation, alternative pathway
Q0006958biological_processcomplement activation, classical pathway
Q0022829molecular_functionwide pore channel activity
Q0031640biological_processkilling of cells of another organism
Q0044218cellular_componentother organism cell membrane
Q0045087biological_processinnate immune response
Q0050778biological_processpositive regulation of immune response
Q0051260biological_processprotein homooligomerization
Q0055085biological_processtransmembrane transport
Q0070062cellular_componentextracellular exosome
Q0072562cellular_componentblood microparticle
Q0160257biological_processcomplement activation, GZMK pathway
R0001906biological_processcell killing
R0002376biological_processimmune system process
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005579cellular_componentmembrane attack complex
R0005615cellular_componentextracellular space
R0005886cellular_componentplasma membrane
R0006955biological_processimmune response
R0006956biological_processcomplement activation
R0006957biological_processcomplement activation, alternative pathway
R0006958biological_processcomplement activation, classical pathway
R0022829molecular_functionwide pore channel activity
R0031640biological_processkilling of cells of another organism
R0044218cellular_componentother organism cell membrane
R0045087biological_processinnate immune response
R0050778biological_processpositive regulation of immune response
R0051260biological_processprotein homooligomerization
R0055085biological_processtransmembrane transport
R0070062cellular_componentextracellular exosome
R0072562cellular_componentblood microparticle
R0160257biological_processcomplement activation, GZMK pathway
S0001906biological_processcell killing
S0002376biological_processimmune system process
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005579cellular_componentmembrane attack complex
S0005615cellular_componentextracellular space
S0005886cellular_componentplasma membrane
S0006955biological_processimmune response
S0006956biological_processcomplement activation
S0006957biological_processcomplement activation, alternative pathway
S0006958biological_processcomplement activation, classical pathway
S0022829molecular_functionwide pore channel activity
S0031640biological_processkilling of cells of another organism
S0044218cellular_componentother organism cell membrane
S0045087biological_processinnate immune response
S0050778biological_processpositive regulation of immune response
S0051260biological_processprotein homooligomerization
S0055085biological_processtransmembrane transport
S0070062cellular_componentextracellular exosome
S0072562cellular_componentblood microparticle
S0160257biological_processcomplement activation, GZMK pathway
T0001906biological_processcell killing
T0002376biological_processimmune system process
T0005515molecular_functionprotein binding
T0005576cellular_componentextracellular region
T0005579cellular_componentmembrane attack complex
T0005615cellular_componentextracellular space
T0005886cellular_componentplasma membrane
T0006955biological_processimmune response
T0006956biological_processcomplement activation
T0006957biological_processcomplement activation, alternative pathway
T0006958biological_processcomplement activation, classical pathway
T0022829molecular_functionwide pore channel activity
T0031640biological_processkilling of cells of another organism
T0044218cellular_componentother organism cell membrane
T0045087biological_processinnate immune response
T0050778biological_processpositive regulation of immune response
T0051260biological_processprotein homooligomerization
T0055085biological_processtransmembrane transport
T0070062cellular_componentextracellular exosome
T0072562cellular_componentblood microparticle
T0160257biological_processcomplement activation, GZMK pathway
U0001906biological_processcell killing
U0002376biological_processimmune system process
U0005515molecular_functionprotein binding
U0005576cellular_componentextracellular region
U0005579cellular_componentmembrane attack complex
U0005615cellular_componentextracellular space
U0005886cellular_componentplasma membrane
U0006955biological_processimmune response
U0006956biological_processcomplement activation
U0006957biological_processcomplement activation, alternative pathway
U0006958biological_processcomplement activation, classical pathway
U0022829molecular_functionwide pore channel activity
U0031640biological_processkilling of cells of another organism
U0044218cellular_componentother organism cell membrane
U0045087biological_processinnate immune response
U0050778biological_processpositive regulation of immune response
U0051260biological_processprotein homooligomerization
U0055085biological_processtransmembrane transport
U0070062cellular_componentextracellular exosome
U0072562cellular_componentblood microparticle
U0160257biological_processcomplement activation, GZMK pathway
V0001906biological_processcell killing
V0002376biological_processimmune system process
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005579cellular_componentmembrane attack complex
V0005615cellular_componentextracellular space
V0005886cellular_componentplasma membrane
V0006955biological_processimmune response
V0006956biological_processcomplement activation
V0006957biological_processcomplement activation, alternative pathway
V0006958biological_processcomplement activation, classical pathway
V0022829molecular_functionwide pore channel activity
V0031640biological_processkilling of cells of another organism
V0044218cellular_componentother organism cell membrane
V0045087biological_processinnate immune response
V0050778biological_processpositive regulation of immune response
V0051260biological_processprotein homooligomerization
V0055085biological_processtransmembrane transport
V0070062cellular_componentextracellular exosome
V0072562cellular_componentblood microparticle
V0160257biological_processcomplement activation, GZMK pathway
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CaCpfKfeGIaC
ChainResidueDetails
ACYS507-CYS518

site_idPS00279
Number of Residues12
DetailsMACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YfafletYGTHY
ChainResidueDetails
ATYR314-TYR325

site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. ClCacPFkfegia..C
ChainResidueDetails
ACYS505-CYS518

site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIkmrlr.CNgdnDCgdfsDEDd....C
ChainResidueDetails
ACYS91-CYS113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues484
DetailsTransmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1166
DetailsDomain: {"description":"TSP type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues660
DetailsDomain: {"description":"EGF-like"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues22
DetailsGlycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"10551839","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues22
DetailsGlycosylation: {"description":"C-linked (Man) tryptophan; partial","evidences":[{"source":"PubMed","id":"10551839","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues22
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues22
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4055801","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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