Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FL7

Structure of the F1c10 complex from Yarrowia lipolytica ATP synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
D	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0043531	molecular_function	ADP binding
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
E	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0043531	molecular_function	ADP binding
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
F	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0043531	molecular_function	ADP binding
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005756	cellular_component	mitochondrial proton-transporting ATP synthase, central stalk
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006754	biological_process	ATP biosynthetic process
K	0006811	biological_process	monoatomic ion transport
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016020	cellular_component	membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	1902600	biological_process	proton transmembrane transport
L	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006754	biological_process	ATP biosynthetic process
L	0006811	biological_process	monoatomic ion transport
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
L	1902600	biological_process	proton transmembrane transport
M	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006754	biological_process	ATP biosynthetic process
M	0006811	biological_process	monoatomic ion transport
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
M	1902600	biological_process	proton transmembrane transport
N	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006754	biological_process	ATP biosynthetic process
N	0006811	biological_process	monoatomic ion transport
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016020	cellular_component	membrane
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
N	1902600	biological_process	proton transmembrane transport
O	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006754	biological_process	ATP biosynthetic process
O	0006811	biological_process	monoatomic ion transport
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
O	1902600	biological_process	proton transmembrane transport
P	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006754	biological_process	ATP biosynthetic process
P	0006811	biological_process	monoatomic ion transport
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016020	cellular_component	membrane
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
P	1902600	biological_process	proton transmembrane transport
Q	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006754	biological_process	ATP biosynthetic process
Q	0006811	biological_process	monoatomic ion transport
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0016020	cellular_component	membrane
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
Q	1902600	biological_process	proton transmembrane transport
R	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006754	biological_process	ATP biosynthetic process
R	0006811	biological_process	monoatomic ion transport
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0016020	cellular_component	membrane
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
R	1902600	biological_process	proton transmembrane transport
S	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006754	biological_process	ATP biosynthetic process
S	0006811	biological_process	monoatomic ion transport
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0016020	cellular_component	membrane
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
S	1902600	biological_process	proton transmembrane transport
T	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0006754	biological_process	ATP biosynthetic process
T	0006811	biological_process	monoatomic ion transport
T	0008289	molecular_function	lipid binding
T	0015078	molecular_function	proton transmembrane transporter activity
T	0015986	biological_process	proton motive force-driven ATP synthesis
T	0016020	cellular_component	membrane
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
T	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP A 600

Chain	Residue
A	GLN198
A	GLN456
A	GLN458
A	MG601
A	HOH2001
A	HOH2003
A	THR199
A	GLY200
A	LYS201
A	THR202
A	GLN203
A	PHE383
A	ARG388
A	PRO389

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	THR202
A	ATP600
A	HOH2001
A	HOH2002
A	HOH2003

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP B 600

Chain	Residue
B	GLN198
B	THR199
B	GLY200
B	LYS201
B	THR202
B	GLN203
B	PHE383
B	PRO389
B	GLN456
B	LYS457
B	GLN458
B	MG601
B	HOH2001
B	HOH2002
B	HOH2003
E	ARG387
E	ASP390

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 601

Chain	Residue
B	THR202
B	ATP600
B	HOH2001
B	HOH2002
B	HOH2003

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP C 600

Chain	Residue
C	ARG197
C	GLN198
C	THR199
C	GLY200
C	LYS201
C	THR202
C	GLN203
C	PHE383
C	ARG388
C	PRO389
C	GLN456
C	GLN458
C	MG601
C	HOH2002
C	HOH2003
F	ASP390

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 601

Chain	Residue
C	THR202
C	ATP600
C	HOH2001
C	HOH2002
C	HOH2003

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP D 600

Chain	Residue
C	VAL397
C	SER398
C	ARG399
D	GLY189
D	GLY191
D	GLY193
D	LYS194
D	THR195
D	VAL196
D	TYR376
D	PHE449
D	ALA452
D	PHE455
D	MG601
D	HOH2001
D	HOH2003
D	HOH2004

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 601

Chain	Residue
D	THR195
D	ARG221
D	ADP600
D	HOH2001
D	HOH2002
D	HOH2003
D	HOH2004

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP F 600

Chain	Residue
F	HOH2004
B	VAL397
B	ARG399
F	GLY191
F	GLY193
F	LYS194
F	THR195
F	VAL196
F	TYR376
F	PHE449
F	PHE455
F	MG601
F	HOH2001
F	HOH2003

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG F 601

Chain	Residue
F	THR195
F	GLU220
F	ADP600
F	HOH2001
F	HOH2002
F	HOH2003
F	HOH2004

Functional Information from PROSITE/UniProt

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITnElvDiitGAsS

Chain	Residue	Details
G	ILE278-SER291

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. SRNPalkgqLfTysILgfaLsE

Chain	Residue	Details
K	SER38-GLU59

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSKS

Chain	Residue	Details
D	PRO377-SER386
A	PRO389-SER398

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
K	LEU14-ILE34
O	ILE52-LEU72
P	LEU14-ILE34
P	ILE52-LEU72
Q	LEU14-ILE34
Q	ILE52-LEU72
R	LEU14-ILE34
R	ILE52-LEU72
S	LEU14-ILE34
S	ILE52-LEU72
T	LEU14-ILE34
K	ILE52-LEU72
T	ILE52-LEU72
L	LEU14-ILE34
L	ILE52-LEU72
M	LEU14-ILE34
M	ILE52-LEU72
N	LEU14-ILE34
N	ILE52-LEU72
O	LEU14-ILE34

site_id	SWS_FT_FI2
Number of Residues	10
Details	SITE: Reversibly protonated during proton transport => ECO:0000305\|PubMed:27373333

Chain	Residue	Details
K	GLU59
T	GLU59
L	GLU59
M	GLU59
N	GLU59
O	GLU59
P	GLU59
Q	GLU59
R	GLU59
S	GLU59

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N-formylmethionine => ECO:0000269\|PubMed:7533057

Chain	Residue	Details
K	MET1
T	MET1
L	MET1
M	MET1
N	MET1
O	MET1
P	MET1
Q	MET1
R	MET1
S	MET1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)