5FJK

Crystal structure of human JMJD2C catalytic domain in complex 6-ethyl- 5-methyl-7-oxo-4,7-dihydropyrazolo(1,5-a)pyrimidine-3-carbonitrile

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1348

Chain	Residue
A	CYS236
A	HIS242
A	CYS308
A	CYS310

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 1349

Chain	Residue
A	HOH2227
A	HIS190
A	GLU192
A	HIS278
A	EM61350
A	HOH2221

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EM6 A 1350

Chain	Residue
A	TYR134
A	THR186
A	PHE187
A	HIS190
A	ASN200
A	LYS208
A	HIS278
A	ASN282
A	NI1349
A	HOH2221
A	HOH2227
A	HOH2346

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1351

Chain	Residue
A	ARG112
A	ASN126
A	TRP183

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1352

Chain	Residue
A	TYR179
A	SER290

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1353

Chain	Residue
A	ALA238
A	PHE239
A	LEU240
A	HOH2264

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1354

Chain	Residue
A	PRO111
A	PRO111
A	ARG112
A	ARG112

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1355

Chain	Residue
A	ASN88
A	GLN90
A	EDO1356
A	HOH2347
A	HOH2348

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1356

Chain	Residue
A	GLN90
A	EDO1355

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1357

Chain	Residue
A	LYS56
A	GLU149
A	HOH2078
A	HOH2349
A	HOH2350

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1358

Chain	Residue
A	TYR116
A	GLU117
A	GLU120
A	SER209
A	LYS261
A	HOH2288

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1359

Chain	Residue
A	LYS107
A	GLN327
A	PRO328
A	ASP329
A	HOH2335

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21914792","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---