Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FCR

MOUSE COMPLEMENT FACTOR D

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006957	biological_process	complement activation, alternative pathway
A	0007219	biological_process	Notch signaling pathway
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009617	biological_process	response to bacterium
A	0016787	molecular_function	hydrolase activity
A	0031638	biological_process	zymogen activation
A	0035886	biological_process	vascular associated smooth muscle cell differentiation
A	0045087	biological_process	innate immune response
A	0051604	biological_process	protein maturation
A	0060041	biological_process	retina development in camera-type eye
B	0002376	biological_process	immune system process
B	0004175	molecular_function	endopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006957	biological_process	complement activation, alternative pathway
B	0007219	biological_process	Notch signaling pathway
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009617	biological_process	response to bacterium
B	0016787	molecular_function	hydrolase activity
B	0031638	biological_process	zymogen activation
B	0035886	biological_process	vascular associated smooth muscle cell differentiation
B	0045087	biological_process	innate immune response
B	0051604	biological_process	protein maturation
B	0060041	biological_process	retina development in camera-type eye
C	0002376	biological_process	immune system process
C	0004175	molecular_function	endopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0006957	biological_process	complement activation, alternative pathway
C	0007219	biological_process	Notch signaling pathway
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009617	biological_process	response to bacterium
C	0016787	molecular_function	hydrolase activity
C	0031638	biological_process	zymogen activation
C	0035886	biological_process	vascular associated smooth muscle cell differentiation
C	0045087	biological_process	innate immune response
C	0051604	biological_process	protein maturation
C	0060041	biological_process	retina development in camera-type eye
D	0002376	biological_process	immune system process
D	0004175	molecular_function	endopeptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006508	biological_process	proteolysis
D	0006957	biological_process	complement activation, alternative pathway
D	0007219	biological_process	Notch signaling pathway
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009617	biological_process	response to bacterium
D	0016787	molecular_function	hydrolase activity
D	0031638	biological_process	zymogen activation
D	0035886	biological_process	vascular associated smooth muscle cell differentiation
D	0045087	biological_process	innate immune response
D	0051604	biological_process	protein maturation
D	0060041	biological_process	retina development in camera-type eye

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue EPE B 301

Chain	Residue
B	HIS91
B	GLU100
B	ASP101
B	ASN179
B	SER233
B	TYR234
B	MET236
B	TRP237
B	HOH545

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL B 302

Chain	Residue
B	GLU21
B	ARG150
B	PRO152
B	ASP153
B	VAL154
B	HIS156

site_id	AC3
Number of Residues	10
Details	binding site for residue EPE C 301

Chain	Residue
C	HIS91
C	GLU100
C	ASP101
C	ASN179
C	SER233
C	TYR234
C	MET236
C	TRP237
C	HOH432
C	HOH515

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG150
C	PRO152
C	ASP153
C	VAL154
C	HIS156

site_id	AC5
Number of Residues	6
Details	binding site for residue DMS D 301

Chain	Residue
D	HIS91
D	TYR234
D	MET236
D	TRP237
D	HOH493
D	HOH556

site_id	AC6
Number of Residues	6
Details	binding site for residue DMS D 302

Chain	Residue
D	GLU21
D	ARG150
D	PRO152
D	ASP153
D	VAL154
D	HIS156

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
A	LEU53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DTcrGDSGSPLV

Chain	Residue	Details
A	ASP189-VAL200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	912
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Self-inhibitor loop","evidences":[{"source":"UniProtKB","id":"P00746","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"P00746","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16944957","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17330941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)