5FCR
MOUSE COMPLEMENT FACTOR D
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0006957 | biological_process | complement activation, alternative pathway |
| A | 0007219 | biological_process | Notch signaling pathway |
| A | 0009617 | biological_process | response to bacterium |
| A | 0031638 | biological_process | zymogen activation |
| A | 0035886 | biological_process | vascular associated smooth muscle cell differentiation |
| A | 0051604 | biological_process | protein maturation |
| A | 0060041 | biological_process | retina development in camera-type eye |
| B | 0004175 | molecular_function | endopeptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0006957 | biological_process | complement activation, alternative pathway |
| B | 0007219 | biological_process | Notch signaling pathway |
| B | 0009617 | biological_process | response to bacterium |
| B | 0031638 | biological_process | zymogen activation |
| B | 0035886 | biological_process | vascular associated smooth muscle cell differentiation |
| B | 0051604 | biological_process | protein maturation |
| B | 0060041 | biological_process | retina development in camera-type eye |
| C | 0004175 | molecular_function | endopeptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0006957 | biological_process | complement activation, alternative pathway |
| C | 0007219 | biological_process | Notch signaling pathway |
| C | 0009617 | biological_process | response to bacterium |
| C | 0031638 | biological_process | zymogen activation |
| C | 0035886 | biological_process | vascular associated smooth muscle cell differentiation |
| C | 0051604 | biological_process | protein maturation |
| C | 0060041 | biological_process | retina development in camera-type eye |
| D | 0004175 | molecular_function | endopeptidase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006508 | biological_process | proteolysis |
| D | 0006957 | biological_process | complement activation, alternative pathway |
| D | 0007219 | biological_process | Notch signaling pathway |
| D | 0009617 | biological_process | response to bacterium |
| D | 0031638 | biological_process | zymogen activation |
| D | 0035886 | biological_process | vascular associated smooth muscle cell differentiation |
| D | 0051604 | biological_process | protein maturation |
| D | 0060041 | biological_process | retina development in camera-type eye |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue EPE B 301 |
| Chain | Residue |
| B | HIS91 |
| B | GLU100 |
| B | ASP101 |
| B | ASN179 |
| B | SER233 |
| B | TYR234 |
| B | MET236 |
| B | TRP237 |
| B | HOH545 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | GLU21 |
| B | ARG150 |
| B | PRO152 |
| B | ASP153 |
| B | VAL154 |
| B | HIS156 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue EPE C 301 |
| Chain | Residue |
| C | HIS91 |
| C | GLU100 |
| C | ASP101 |
| C | ASN179 |
| C | SER233 |
| C | TYR234 |
| C | MET236 |
| C | TRP237 |
| C | HOH432 |
| C | HOH515 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 302 |
| Chain | Residue |
| C | ARG150 |
| C | PRO152 |
| C | ASP153 |
| C | VAL154 |
| C | HIS156 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue DMS D 301 |
| Chain | Residue |
| D | HIS91 |
| D | TYR234 |
| D | MET236 |
| D | TRP237 |
| D | HOH493 |
| D | HOH556 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue DMS D 302 |
| Chain | Residue |
| D | GLU21 |
| D | ARG150 |
| D | PRO152 |
| D | ASP153 |
| D | VAL154 |
| D | HIS156 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 912 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Self-inhibitor loop","evidences":[{"source":"UniProtKB","id":"P00746","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"P00746","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16944957","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17330941","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
