5FAE

N184K pathological variant of gelsolin domain 2 (trigonal form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 301

Chain	Residue
A	GLY186
A	ASP187
A	GLU209
A	HOH402
A	HOH433
A	HOH453

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG168
A	ASN206
A	ARG207

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 303

Chain	Residue
A	GLN164
A	LYS166
A	LYS218
A	ARG221
A	HOH420
A	HOH428

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 304

Chain	Residue
A	GLY148
A	ARG172
A	ALA173
A	LYS212
A	ARG230
A	HOH424

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 305

Chain	Residue
A	ARG168
A	ASN206
A	HOH402

---

site_id	AC6
Number of Residues	5
Details	binding site for residue PEG A 306

Chain	Residue
A	ASN185
A	TRP200
A	GLU239
A	LYS250
A	PRO251

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CL A 307

Chain	Residue
A	GLY148
A	HIS151
A	HIS232
A	HOH424

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Repeat: {"description":"Gelsolin-like 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19666512","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FFK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---