5F7O

Crystal structure of Mutant Q289L of adenosine/Methylthioadenosine phosphorylase from Schistosoma mansoni in complex with Adenine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0003824	molecular_function	catalytic activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0009116	biological_process	nucleoside metabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0003824	molecular_function	catalytic activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0009116	biological_process	nucleoside metabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
C	0019509	biological_process	L-methionine salvage from methylthioadenosine

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ADE A 301

Chain	Residue
A	ALA88
A	ASP232
A	HOH434
A	HOH501
A	CYS89
A	GLY90
A	PHE187
A	VAL204
A	ASN205
A	MET206
A	THR229
A	ASP230

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site_id	AC2
Number of Residues	11
Details	binding site for residue ADE B 301

Chain	Residue
B	ALA88
B	CYS89
B	GLY90
B	PHE187
B	VAL204
B	ASN205
B	THR229
B	ASP230
B	ASP232
B	VAL241
B	HOH474

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site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 B 302

Chain	Residue
B	GLY11
B	SER12
B	ARG54
B	HIS55
B	ASN87
B	ALA88
B	THR207
B	HOH470
B	HOH490

---

site_id	AC4
Number of Residues	11
Details	binding site for residue SO4 C 301

Chain	Residue
C	GLY11
C	SER12
C	ARG54
C	HIS55
C	ASN87
C	ALA88
C	THR207
C	HOH475
C	HOH481
C	HOH532
C	HOH579

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Functional Information from PROSITE/UniProt

site_id	PS01240
Number of Residues	41
Details	PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGkgHlIppseVnyrAn.VwAlkdlGcth.ILatNAcGSL

Chain	Residue	Details
A	LEU52-LEU92

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