5F6K
Crystal structure of the MLL3-Ash2L-RbBP5 complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 5001 |
| Chain | Residue |
| C | CYS4851 |
| C | CYS4899 |
| C | CYS4901 |
| C | CYS4906 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue SAH C 5002 |
| Chain | Residue |
| C | TYR4825 |
| C | ARG4845 |
| C | TYR4846 |
| C | ASN4848 |
| C | HIS4849 |
| C | TYR4886 |
| C | PRO4898 |
| C | CYS4899 |
| C | HIS4900 |
| C | ILE4780 |
| C | GLN4781 |
| C | GLY4782 |
| C | LEU4783 |
| C | VAL4824 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 5001 |
| Chain | Residue |
| E | CYS4851 |
| E | CYS4899 |
| E | CYS4901 |
| E | CYS4906 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue SAH E 5002 |
| Chain | Residue |
| E | ILE4780 |
| E | GLN4781 |
| E | GLY4782 |
| E | LEU4783 |
| E | TYR4825 |
| E | ARG4845 |
| E | TYR4846 |
| E | ASN4848 |
| E | HIS4849 |
| E | TYR4886 |
| E | CYS4899 |
| E | HIS4900 |
| E | MET4910 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| M | ARG2 | |
| F | SER350 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by HASPIN => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| M | THR3 | |
| E | CYS4906 | |
| C | CYS4851 | |
| C | CYS4899 | |
| C | CYS4901 | |
| C | CYS4906 | |
| E | ASN4848 | |
| E | CYS4851 | |
| E | CYS4899 | |
| E | CYS4901 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| M | LYS4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| M | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| M | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| M | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P68432 |
| Chain | Residue | Details |
| M | LYS9 |
