5F6K

Crystal structure of the MLL3-Ash2L-RbBP5 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0048188	cellular_component	Set1C/COMPASS complex
B	0048188	cellular_component	Set1C/COMPASS complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN C 5001

Chain	Residue
C	CYS4851
C	CYS4899
C	CYS4901
C	CYS4906

---

site_id	AC2
Number of Residues	14
Details	binding site for residue SAH C 5002

Chain	Residue
C	TYR4825
C	ARG4845
C	TYR4846
C	ASN4848
C	HIS4849
C	TYR4886
C	PRO4898
C	CYS4899
C	HIS4900
C	ILE4780
C	GLN4781
C	GLY4782
C	LEU4783
C	VAL4824

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN E 5001

Chain	Residue
E	CYS4851
E	CYS4899
E	CYS4901
E	CYS4906

---

site_id	AC4
Number of Residues	13
Details	binding site for residue SAH E 5002

Chain	Residue
E	ILE4780
E	GLN4781
E	GLY4782
E	LEU4783
E	TYR4825
E	ARG4845
E	TYR4846
E	ASN4848
E	HIS4849
E	TYR4886
E	CYS4899
E	HIS4900
E	MET4910

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---