5F28

Crystal structure of FAT domain of Focal Adhesion Kinase (FAK) bound to the transcription factor MEF2C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046983	molecular_function	protein dimerization activity
B	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046983	molecular_function	protein dimerization activity
C	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046983	molecular_function	protein dimerization activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0005925	cellular_component	focal adhesion
E	0006468	biological_process	protein phosphorylation
E	0007172	biological_process	signal complex assembly
F	0004713	molecular_function	protein tyrosine kinase activity
F	0005925	cellular_component	focal adhesion
F	0006468	biological_process	protein phosphorylation
F	0007172	biological_process	signal complex assembly
G	0004713	molecular_function	protein tyrosine kinase activity
G	0005925	cellular_component	focal adhesion
G	0006468	biological_process	protein phosphorylation
G	0007172	biological_process	signal complex assembly

Functional Information from PROSITE/UniProt

site_id	PS00350
Number of Residues	55
Details	MADS_BOX_1 MADS-box domain signature. RkKiqitrImDernRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnstnkLfqY

Chain	Residue	Details
A	ARG3-TYR57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	112
Details	DNA binding: {"description":"Mef2-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"8663403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"11420674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7997267","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8816475","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9148935","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18034455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---