5F0W

Crystal structure of human copper homeostatic proteins atox1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006811	biological_process	monoatomic ion transport
A	0006825	biological_process	copper ion transport
A	0006878	biological_process	intracellular copper ion homeostasis
A	0006979	biological_process	response to oxidative stress
A	0016530	molecular_function	metallochaperone activity
A	0016531	molecular_function	copper chaperone activity
A	0032767	molecular_function	copper-dependent protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0046872	molecular_function	metal ion binding
A	0051117	molecular_function	ATPase binding
A	0060003	biological_process	copper ion export
A	1903136	molecular_function	cuprous ion binding
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006811	biological_process	monoatomic ion transport
B	0006825	biological_process	copper ion transport
B	0006878	biological_process	intracellular copper ion homeostasis
B	0006979	biological_process	response to oxidative stress
B	0016530	molecular_function	metallochaperone activity
B	0016531	molecular_function	copper chaperone activity
B	0032767	molecular_function	copper-dependent protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0046872	molecular_function	metal ion binding
B	0051117	molecular_function	ATPase binding
B	0060003	biological_process	copper ion export
B	1903136	molecular_function	cuprous ion binding
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006811	biological_process	monoatomic ion transport
C	0006825	biological_process	copper ion transport
C	0006878	biological_process	intracellular copper ion homeostasis
C	0006979	biological_process	response to oxidative stress
C	0016530	molecular_function	metallochaperone activity
C	0016531	molecular_function	copper chaperone activity
C	0032767	molecular_function	copper-dependent protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0046872	molecular_function	metal ion binding
C	0051117	molecular_function	ATPase binding
C	0060003	biological_process	copper ion export
C	1903136	molecular_function	cuprous ion binding
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006811	biological_process	monoatomic ion transport
D	0006825	biological_process	copper ion transport
D	0006878	biological_process	intracellular copper ion homeostasis
D	0006979	biological_process	response to oxidative stress
D	0016530	molecular_function	metallochaperone activity
D	0016531	molecular_function	copper chaperone activity
D	0032767	molecular_function	copper-dependent protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0046872	molecular_function	metal ion binding
D	0051117	molecular_function	ATPase binding
D	0060003	biological_process	copper ion export
D	1903136	molecular_function	cuprous ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue AG A 101

Chain	Residue
A	GLY14
A	CYS15
A	LYS60
A	AG102
A	HOH203
B	THR11
B	CYS12
B	AG102

---

site_id	AC2
Number of Residues	7
Details	binding site for residue AG A 102

Chain	Residue
A	CYS12
A	CYS15
A	AG101
B	CYS12
B	AG101
B	AG102
A	THR11

---

site_id	AC3
Number of Residues	8
Details	binding site for residue AG B 101

Chain	Residue
A	THR11
A	CYS12
A	AG102
B	GLY14
B	CYS15
B	LYS60
B	AG102
B	HOH202

---

site_id	AC4
Number of Residues	7
Details	binding site for residue AG B 102

Chain	Residue
A	CYS12
A	AG101
A	AG102
B	THR11
B	CYS12
B	CYS15
B	AG101

---

site_id	AC5
Number of Residues	7
Details	binding site for residue AG C 101

Chain	Residue
C	GLY14
C	CYS15
C	AG102
D	THR11
D	CYS12
D	AG102
D	HOH202

---

site_id	AC6
Number of Residues	7
Details	binding site for residue AG C 102

Chain	Residue
C	THR11
C	CYS12
C	CYS15
C	AG101
D	CYS12
D	AG101
D	AG102

---

site_id	AC7
Number of Residues	8
Details	binding site for residue AG D 101

Chain	Residue
C	THR11
C	CYS12
C	AG102
D	GLY14
D	CYS15
D	LYS60
D	AG102
D	HOH203

---

site_id	AC8
Number of Residues	7
Details	binding site for residue AG D 102

Chain	Residue
C	CYS12
C	AG101
C	AG102
D	THR11
D	CYS12
D	CYS15
D	AG101

---

Functional Information from PROSITE/UniProt

site_id	PS01047
Number of Residues	29
Details	HMA_1 Heavy-metal-associated domain. SvDMtCgGCaeaVSrvLnklggvkyd..IdL

Chain	Residue	Details
A	SER7-LEU35

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	248
Details	Domain: {"description":"HMA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00280","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00280","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31283225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5T7L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O08997","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---