5F0S
Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer and manganese ion
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 A 501 |
| Chain | Residue |
| A | PRO286 |
| A | CYS287 |
| A | CYS367 |
| A | CYS384 |
| A | CYS424 |
| A | LEU441 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 B 501 |
| Chain | Residue |
| B | CYS367 |
| B | CYS384 |
| B | PHE386 |
| B | CYS424 |
| B | PRO444 |
| B | PRO285 |
| B | PRO286 |
| B | CYS287 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue MN C 101 |
| Chain | Residue |
| C | GTP1 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MN E 101 |
| Chain | Residue |
| B | TYR345 |
| E | GTP1 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for Di-nucleotide GTP E 1 and G E 2 |
| Chain | Residue |
| B | HIS300 |
| B | ARG302 |
| B | HIS303 |
| B | ARG306 |
| B | TYR345 |
| E | C3 |
| E | MN101 |
| F | DC5 |
| F | DC6 |
| F | DA7 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 284 |
| Details | Region: {"description":"RNA:DNA duplex-binding","evidences":[{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17893144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17893144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
