5F03
TRYPTASE B2 IN COMPLEX WITH 5-(3-Aminomethyl-phenoxymethyl)-3-[3-(2-chloro-pyridin-3-ylethynyl)-phenyl]-oxazolidin-2-one; compound with trifluoro-acetic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006952 | biological_process | defense response |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0006952 | biological_process | defense response |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0022617 | biological_process | extracellular matrix disassembly |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0062023 | cellular_component | collagen-containing extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 5TA A 301 |
| Chain | Residue |
| A | GLN98 |
| A | TRP215 |
| A | GLY216 |
| A | GLU217 |
| A | GLY219 |
| A | ARG224 |
| A | HOH503 |
| A | HOH554 |
| B | ASP60 |
| A | TYR172 |
| A | ILE175 |
| A | ASP189 |
| A | SER190 |
| A | CYS191 |
| A | GLN192 |
| A | SER195 |
| A | VAL213 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue 5TA B 301 |
| Chain | Residue |
| A | PRO60 |
| A | ASP60 |
| B | GLN98 |
| B | TYR172 |
| B | ILE175 |
| B | ASP189 |
| B | SER190 |
| B | CYS191 |
| B | GLN192 |
| B | SER195 |
| B | VAL213 |
| B | TRP215 |
| B | GLY216 |
| B | GLU217 |
| B | GLY219 |
| B | ARG224 |
| B | HOH540 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
| B | HIS57 | |
| B | ASP102 | |
| B | SER195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21845 |
| Chain | Residue | Details |
| A | TYR75 | |
| B | TYR75 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN204 | |
| B | ASN204 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS113 | |
| B | LYS113 |
