5EXI
Crystal structure of M. tuberculosis lipoyl synthase at 2.28 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009107 | biological_process | lipoate biosynthetic process |
| A | 0009249 | biological_process | protein lipoylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0016992 | molecular_function | lipoate synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SF4 A 401 |
| Chain | Residue |
| A | CYS81 |
| A | CYS85 |
| A | CYS88 |
| A | ARG192 |
| A | PHE195 |
| A | DTV403 |
| A | HOH502 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 A 402 |
| Chain | Residue |
| A | ASN62 |
| A | ILE63 |
| A | CYS66 |
| A | THR73 |
| A | ARG290 |
| A | SER292 |
| A | TYR293 |
| A | CYS55 |
| A | CYS60 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue DTV A 403 |
| Chain | Residue |
| A | GLY122 |
| A | LEU155 |
| A | SF4401 |
| A | HOH502 |
| A | HOH541 |
| A | HOH594 |
| A | HOH637 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 214 |
| Details | Domain: {"description":"Radical SAM core","evidences":[{"source":"PROSITE-ProRule","id":"PRU01266","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00206","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27506792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EXJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00206","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27506792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EXK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
