5EU6
HLA Class I antigen
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001913 | biological_process | T cell mediated cytotoxicity |
| B | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
| B | 0002237 | biological_process | response to molecule of bacterial origin |
| B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| B | 0002481 | biological_process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
| B | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0002726 | biological_process | positive regulation of T cell cytokine production |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006955 | biological_process | immune response |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0007611 | biological_process | learning or memory |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0010977 | biological_process | negative regulation of neuron projection development |
| B | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031905 | cellular_component | early endosome lumen |
| B | 0032092 | biological_process | positive regulation of protein binding |
| B | 0033077 | biological_process | T cell differentiation in thymus |
| B | 0034756 | biological_process | regulation of iron ion transport |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042026 | biological_process | protein refolding |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042824 | cellular_component | MHC class I peptide loading complex |
| B | 0045646 | biological_process | regulation of erythrocyte differentiation |
| B | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| B | 0050768 | biological_process | negative regulation of neurogenesis |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0071283 | biological_process | cellular response to iron(III) ion |
| B | 0071316 | biological_process | cellular response to nicotine |
| B | 1900121 | biological_process | negative regulation of receptor binding |
| B | 1900122 | biological_process | positive regulation of receptor binding |
| B | 1904434 | biological_process | positive regulation of ferrous iron binding |
| B | 1904437 | biological_process | positive regulation of transferrin receptor binding |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1990000 | biological_process | amyloid fibril formation |
| B | 1990712 | cellular_component | HFE-transferrin receptor complex |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
| B | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
| D | 0002250 | biological_process | adaptive immune response |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009617 | biological_process | response to bacterium |
| D | 0042101 | cellular_component | T cell receptor complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | ASP122 |
| A | TYR123 |
| A | ILE124 |
| A | ALA125 |
| A | THR134 |
| A | ALA136 |
| A | HOH472 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | LYS121 |
| A | ASP122 |
| A | ASP137 |
| A | EDO303 |
| A | TYR85 |
| A | TYR118 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | GLN87 |
| A | ASP119 |
| A | LYS121 |
| A | EDO302 |
| B | MET0 |
| D | EDO301 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ARG65 |
| A | HOH410 |
| E | ALA55 |
| E | ASP57 |
| E | ASP58 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | SER13 |
| A | ARG14 |
| A | GLU19 |
| A | PRO20 |
| A | LEU78 |
| A | SO4310 |
| A | HOH406 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | ALA150 |
| A | HIS151 |
| D | TYR32 |
| E | THR101 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | GLU58 |
| A | ASP61 |
| A | GLY62 |
| A | ARG65 |
| A | HOH401 |
| D | GLY98 |
| D | SER99 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | GLU166 |
| A | TRP167 |
| A | ARG170 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 309 |
| Chain | Residue |
| A | ASN86 |
| D | ALA10 |
| D | LYS107 |
| D | GLY108 |
| E | GLY41 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 310 |
| Chain | Residue |
| A | SER13 |
| A | GLY79 |
| A | ARG82 |
| A | EDO305 |
| A | HOH431 |
| A | HOH489 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 311 |
| Chain | Residue |
| A | TYR84 |
| A | MET138 |
| A | ALA139 |
| A | THR142 |
| A | HOH490 |
| D | PRO9 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 301 |
| Chain | Residue |
| A | ARG108 |
| B | ASN42 |
| B | GLY43 |
| B | GLU77 |
| B | TYR78 |
| B | ALA79 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| A | ARG21 |
| A | ILE23 |
| A | ASP37 |
| B | HIS51 |
| B | SER52 |
| B | ASP53 |
| B | LEU54 |
| B | HOH416 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | SER57 |
| B | LYS58 |
| B | ASP59 |
| B | HOH426 |
| site_id | AD6 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| A | TRP204 |
| A | LEU206 |
| A | ARG234 |
| A | GLN242 |
| B | TYR10 |
| B | SER11 |
| B | ARG12 |
| B | HIS13 |
| B | PRO14 |
| B | HOH411 |
| B | HOH422 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 301 |
| Chain | Residue |
| A | TYR85 |
| A | ASP137 |
| A | EDO303 |
| D | THR6 |
| D | SER25 |
| D | ARG73 |
| D | HOH403 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 302 |
| Chain | Residue |
| D | THR27 |
| D | SER29 |
| D | SER70 |
| D | SER71 |
| D | GLY72 |
| D | PHE26 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 303 |
| Chain | Residue |
| D | MET1 |
| D | GLN3 |
| D | ASP28 |
| D | SER95 |
| D | SER96 |
| D | GLY97 |
| D | LYS102 |
| D | HOH418 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO E 301 |
| Chain | Residue |
| A | GLN72 |
| A | VAL76 |
| A | HOH466 |
| E | GLY52 |
| E | THR53 |
| E | HOH442 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL E 302 |
| Chain | Residue |
| E | GLN38 |
| E | SER39 |
| E | LEU40 |
| E | GLY41 |
| E | VAL90 |
| E | SO4303 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 E 303 |
| Chain | Residue |
| E | SER88 |
| E | ALA89 |
| E | ARG111 |
| E | LEU112 |
| E | THR113 |
| E | GOL302 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH |
| Chain | Residue | Details |
| B | TYR78-HIS84 | |
| A | TYR257-HIS263 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| E | ASN185 | |
| D | ASN64 | |
| A | TYR84 | |
| A | THR143 | |
| A | LYS146 | |
| A | TYR171 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| D | ASN148 | |
| D | ASN182 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| D | ASN193 | |
| B | LYS41 | |
| B | LYS48 | |
| B | LYS58 | |
| B | LYS91 | |
| B | LYS94 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN86 |
