5ERJ

X-ray structure of cisplatin-encapsulated horse spleen apoferritin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0070288	cellular_component	ferritin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 201

Chain	Residue
A	ASP80
A	CD208

---

site_id	AC2
Number of Residues	7
Details	binding site for residue CL A 202

Chain	Residue
A	GLU130
A	GLU130
A	CD212
A	CD212
A	CD212
A	HOH337
A	HOH337

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CL A 203

Chain	Residue
A	SER9
A	THR10
A	GLU11
A	CD205

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 204

Chain	Residue
A	GLU45
A	CD216
A	CD217
A	HOH504

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CD A 205

Chain	Residue
A	GLU11
A	CL203
A	HOH386
A	HOH484

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CD A 206

Chain	Residue
A	GLU53
A	GLU56
A	HOH331

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CD A 207

Chain	Residue
A	GLU56
A	GLU60
A	HOH448

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CD A 208

Chain	Residue
A	ASP80
A	CL201

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CD A 209

Chain	Residue
A	GLU88
A	HOH305
A	HOH419
A	HOH432

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CD A 210

Chain	Residue
A	ASP127
A	SER131
A	CD211
A	HOH303
A	HOH463
A	HOH465

---

site_id	AD2
Number of Residues	6
Details	binding site for residue CD A 211

Chain	Residue
A	HIS132
A	ASP135
A	CD210
A	HOH328
A	HOH463
A	HOH465

---

site_id	AD3
Number of Residues	9
Details	binding site for residue CD A 212

Chain	Residue
A	GLU130
A	GLU130
A	GLU130
A	CL202
A	CL202
A	CL202
A	HOH337
A	HOH337
A	HOH337

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CD A 213

Chain	Residue
A	HIS114
A	CYS126
A	GLU130
A	HOH502

---

site_id	AD5
Number of Residues	4
Details	binding site for residue CD A 214

Chain	Residue
A	GLU63
A	HOH314
A	HOH438
A	HOH458

---

site_id	AD6
Number of Residues	4
Details	binding site for residue CD A 215

Chain	Residue
A	CYS48
A	HIS49
A	ARG52
A	HOH442

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CD A 216

Chain	Residue
A	GLU45
A	CL204
A	HOH395
A	HOH504

---

site_id	AD8
Number of Residues	3
Details	binding site for residue CD A 217

Chain	Residue
A	GLU45
A	HIS49
A	CL204

---

site_id	AD9
Number of Residues	4
Details	binding site for residue CPT A 218

Chain	Residue
A	ARG64
A	HIS132
A	HOH332
A	HOH434

---

site_id	AE1
Number of Residues	2
Details	binding site for residue GOL A 219

Chain	Residue
A	GLY90
A	GLU163

---

site_id	AE2
Number of Residues	6
Details	binding site for residue SO4 A 220

Chain	Residue
A	GLN6
A	ASN7
A	HOH307
A	HOH315
A	HOH319
A	HOH382

---

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 A 221

Chain	Residue
A	GLN86
A	ASP87
A	GLU88
A	HOH336

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEshFLdeevklIK

Chain	Residue	Details
A	ASP122-LYS142

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EkREgaERLLkmQNqRgGR

Chain	Residue	Details
A	GLU57-ARG75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	149
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"Catalytic site for iron oxidation"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"7026284","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---