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5EPL

Crystal Structure of chromodomain of CBX4 in complex with inhibitor UNC3866

Functional Information from GO Data
ChainGOidnamespacecontents
A0045892biological_processnegative regulation of DNA-templated transcription
B0045892biological_processnegative regulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for UNC3866 chain C
ChainResidue
AHIS9
ALEU49
AASP50
AARG52
ALEU53
AHOH212
AHOH216
BALA12
CHOH201
CHOH202
CHOH203
AVAL10
APHE11
AALA12
AVAL13
ATRP32
ATRP35
AGLU43
AASN47

site_idAC2
Number of Residues22
Detailsbinding site for UNC3866 chain D
ChainResidue
AGLU8
AHIS9
ALEU49
APRO51
BHIS9
BVAL10
BPHE11
BALA12
BVAL13
BTRP32
BTRP35
BTYR39
BGLU43
BASN47
BLEU49
BASP50
BARG52
BLEU53
BHOH212
BHOH231
DHOH201
DHOH202

Functional Information from PROSITE/UniProt
site_idPS00598
Number of Residues21
DetailsCHROMO_1 Chromo domain signature. YlVKWrGWspkyn.TWEPeenI
ChainResidueDetails
ATYR28-ILE48

222415

PDB entries from 2024-07-10

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