Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5EOM

Structure of full-length human MAB21L1 with bound CTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001654	biological_process	eye development
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0008283	biological_process	cell population proliferation
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009653	biological_process	anatomical structure morphogenesis
A	0016779	molecular_function	nucleotidyltransferase activity
A	0043010	biological_process	camera-type eye development
A	0046872	molecular_function	metal ion binding
B	0001654	biological_process	eye development
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0008283	biological_process	cell population proliferation
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009653	biological_process	anatomical structure morphogenesis
B	0016779	molecular_function	nucleotidyltransferase activity
B	0043010	biological_process	camera-type eye development
B	0046872	molecular_function	metal ion binding
C	0001654	biological_process	eye development
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0008283	biological_process	cell population proliferation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009653	biological_process	anatomical structure morphogenesis
C	0016779	molecular_function	nucleotidyltransferase activity
C	0043010	biological_process	camera-type eye development
C	0046872	molecular_function	metal ion binding
D	0001654	biological_process	eye development
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0008283	biological_process	cell population proliferation
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009653	biological_process	anatomical structure morphogenesis
D	0016779	molecular_function	nucleotidyltransferase activity
D	0043010	biological_process	camera-type eye development
D	0046872	molecular_function	metal ion binding
E	0001654	biological_process	eye development
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0008283	biological_process	cell population proliferation
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009653	biological_process	anatomical structure morphogenesis
E	0016779	molecular_function	nucleotidyltransferase activity
E	0043010	biological_process	camera-type eye development
E	0046872	molecular_function	metal ion binding
F	0001654	biological_process	eye development
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0008283	biological_process	cell population proliferation
F	0008284	biological_process	positive regulation of cell population proliferation
F	0009653	biological_process	anatomical structure morphogenesis
F	0016779	molecular_function	nucleotidyltransferase activity
F	0043010	biological_process	camera-type eye development
F	0046872	molecular_function	metal ion binding
G	0001654	biological_process	eye development
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0008283	biological_process	cell population proliferation
G	0008284	biological_process	positive regulation of cell population proliferation
G	0009653	biological_process	anatomical structure morphogenesis
G	0016779	molecular_function	nucleotidyltransferase activity
G	0043010	biological_process	camera-type eye development
G	0046872	molecular_function	metal ion binding
H	0001654	biological_process	eye development
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0008283	biological_process	cell population proliferation
H	0008284	biological_process	positive regulation of cell population proliferation
H	0009653	biological_process	anatomical structure morphogenesis
H	0016779	molecular_function	nucleotidyltransferase activity
H	0043010	biological_process	camera-type eye development
H	0046872	molecular_function	metal ion binding
I	0001654	biological_process	eye development
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0008283	biological_process	cell population proliferation
I	0008284	biological_process	positive regulation of cell population proliferation
I	0009653	biological_process	anatomical structure morphogenesis
I	0016779	molecular_function	nucleotidyltransferase activity
I	0043010	biological_process	camera-type eye development
I	0046872	molecular_function	metal ion binding
J	0001654	biological_process	eye development
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0008283	biological_process	cell population proliferation
J	0008284	biological_process	positive regulation of cell population proliferation
J	0009653	biological_process	anatomical structure morphogenesis
J	0016779	molecular_function	nucleotidyltransferase activity
J	0043010	biological_process	camera-type eye development
J	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue CIT A 401

Chain	Residue
A	TYR10
A	HIS11
A	LYS14
A	LYS354
A	GLU357
D	TRP343
D	ARG347

site_id	AC2
Number of Residues	5
Details	binding site for residue TMO A 402

Chain	Residue
A	PRO190
A	ILE192
A	PRO195
A	PRO188
A	LEU189

site_id	AC3
Number of Residues	14
Details	binding site for residue CTP A 403

Chain	Residue
A	ARG23
A	LYS24
A	ILE27
A	ILE31
A	ARG62
A	TYR63
A	LEU66
A	VAL68
A	LYS248
A	SER252
A	LYS255
A	HOH502
A	HOH504
A	HOH505

site_id	AC4
Number of Residues	8
Details	binding site for residue CIT B 401

Chain	Residue
B	LYS7
B	TYR10
B	HIS11
B	LYS14
B	LYS354
C	TRP343
C	ARG344
C	ARG347

site_id	AC5
Number of Residues	11
Details	binding site for residue CTP B 402

Chain	Residue
B	ARG23
B	LYS24
B	ILE27
B	ILE31
B	ASN61
B	ARG62
B	TYR63
B	LEU66
B	VAL68
B	SER252
B	LYS255

site_id	AC6
Number of Residues	6
Details	binding site for residue CIT D 401

Chain	Residue
D	TYR10
D	HIS11
D	LYS14
D	LYS354
F	LYS340
F	ARG347

site_id	AC7
Number of Residues	10
Details	binding site for residue CTP D 402

Chain	Residue
D	ARG23
D	LYS24
D	ILE31
D	ARG62
D	TYR63
D	LEU66
D	VAL68
D	LYS248
D	SER252
D	LYS255

site_id	AC8
Number of Residues	8
Details	binding site for residue CIT E 401

Chain	Residue
E	TYR10
E	HIS11
E	LYS14
E	LYS354
E	GLU357
G	TRP343
G	ARG344
G	ARG347

site_id	AC9
Number of Residues	12
Details	binding site for residue CTP E 402

Chain	Residue
E	ARG23
E	LYS24
E	ILE27
E	ILE31
E	ARG62
E	TYR63
E	LEU66
E	VAL68
E	LYS248
E	SER252
E	LYS255
E	HOH501

site_id	AD1
Number of Residues	9
Details	binding site for residue CIT F 401

Chain	Residue
B	LYS340
B	TRP343
B	ARG347
F	TYR10
F	HIS11
F	LYS14
F	LYS354
F	HOH503
F	HOH525

site_id	AD2
Number of Residues	2
Details	binding site for residue TMO F 402

Chain	Residue
F	SER144
F	TYR145

site_id	AD3
Number of Residues	13
Details	binding site for residue CTP F 403

Chain	Residue
F	LEU66
F	VAL68
F	LYS248
F	SER252
F	LYS255
F	HOH510
F	ARG23
F	LYS24
F	ILE27
F	ILE31
F	ASN61
F	ARG62
F	TYR63

site_id	AD4
Number of Residues	6
Details	binding site for residue CIT G 401

Chain	Residue
G	TYR10
G	HIS11
G	LYS14
G	LYS354
I	LYS340
I	TRP343

site_id	AD5
Number of Residues	10
Details	binding site for residue CTP G 402

Chain	Residue
G	ARG23
G	LYS24
G	ILE31
G	ARG62
G	TYR63
G	LEU66
G	VAL68
G	SER252
G	LYS255
G	HOH507

site_id	AD6
Number of Residues	5
Details	binding site for residue CIT H 401

Chain	Residue
H	LYS340
H	ARG347
J	TYR10
J	HIS11
J	LYS354

site_id	AD7
Number of Residues	6
Details	binding site for residue CIT H 402

Chain	Residue
E	LYS340
E	TRP343
H	TYR10
H	HIS11
H	LYS354
H	GLU357

site_id	AD8
Number of Residues	13
Details	binding site for residue CTP H 403

Chain	Residue
H	ARG23
H	LYS24
H	ALA28
H	ARG62
H	TYR63
H	LEU66
H	VAL68
H	LYS248
H	SER252
H	LYS255
H	HOH502
H	HOH504
H	HOH505

site_id	AD9
Number of Residues	8
Details	binding site for residue CIT I 401

Chain	Residue
I	TYR10
I	LYS14
I	LYS354
I	HOH502
I	HOH508
J	LYS340
J	TRP343
J	ARG347

site_id	AE1
Number of Residues	9
Details	binding site for residue CTP I 402

Chain	Residue
I	ARG23
I	LYS24
I	ALA28
I	ILE31
I	ARG62
I	TYR63
I	LYS248
I	SER252
I	LYS255

site_id	AE2
Number of Residues	12
Details	binding site for residue CTP J 401

Chain	Residue
J	ARG23
J	LYS24
J	ALA28
J	ILE31
J	ARG32
J	TYR63
J	LEU66
J	VAL68
J	LYS248
J	SER252
J	LYS255
J	HOH501

site_id	AE3
Number of Residues	7
Details	binding site for residue CIT C 401

Chain	Residue
A	LYS340
A	TRP343
A	ARG344
C	TYR10
C	HIS11
C	LYS14
C	LYS354

site_id	AE4
Number of Residues	4
Details	binding site for residue TMO C 402

Chain	Residue
C	THR72
C	ARG161
C	ARG165
C	VAL167

site_id	AE5
Number of Residues	4
Details	binding site for residue TMO C 403

Chain	Residue
C	PRO188
C	LEU189
C	PRO190
C	ILE192

site_id	AE6
Number of Residues	11
Details	binding site for residue CTP C 404

Chain	Residue
C	ARG23
C	LYS24
C	ILE27
C	ILE31
C	ARG62
C	TYR63
C	LEU66
C	VAL68
C	LYS248
C	SER252
C	LYS255

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269\|PubMed:27271801, ECO:0007744\|PDB:5EOM

Chain	Residue	Details
A	ARG23
D	TYR63
D	LYS248
D	SER252
E	ARG23
E	TYR63
E	LYS248
E	SER252
F	ARG23
F	TYR63
F	LYS248
A	TYR63
F	SER252
G	ARG23
G	TYR63
G	LYS248
G	SER252
H	ARG23
H	TYR63
H	LYS248
H	SER252
I	ARG23
A	LYS248
I	TYR63
I	LYS248
I	SER252
J	ARG23
J	TYR63
J	LYS248
J	SER252
C	ARG23
C	TYR63
C	LYS248
A	SER252
C	SER252
B	ARG23
B	TYR63
B	LYS248
B	SER252
D	ARG23

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q8N884

Chain	Residue	Details
A	GLU73
F	GLU75
G	GLU73
G	GLU75
H	GLU73
H	GLU75
I	GLU73
I	GLU75
J	GLU73
J	GLU75
C	GLU73
A	GLU75
C	GLU75
B	GLU73
B	GLU75
D	GLU73
D	GLU75
E	GLU73
E	GLU75
F	GLU73

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)