5ELN
Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016020 | cellular_component | membrane |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016020 | cellular_component | membrane |
| B | 0016874 | molecular_function | ligase activity |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0016020 | cellular_component | membrane |
| C | 0016874 | molecular_function | ligase activity |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0016020 | cellular_component | membrane |
| D | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue LYS A 601 |
| Chain | Residue |
| A | GLY249 |
| A | HOH910 |
| A | ALA250 |
| A | GLU273 |
| A | GLU311 |
| A | TYR313 |
| A | ASN467 |
| A | TYR469 |
| A | GLU471 |
| A | GLY516 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | ARG227 |
| A | ILE290 |
| A | HOH1090 |
| B | GLU237 |
| B | GLU239 |
| B | EDO602 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | GLY352 |
| A | LYS353 |
| A | CYS354 |
| A | HOH815 |
| B | SER108 |
| B | ILE114 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | HIS446 |
| A | ARG447 |
| A | GLU448 |
| A | PRO450 |
| A | HOH856 |
| A | HOH858 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue LYS B 601 |
| Chain | Residue |
| B | GLY249 |
| B | ALA250 |
| B | ALA271 |
| B | GLU273 |
| B | ARG295 |
| B | GLU311 |
| B | TYR313 |
| B | ASN467 |
| B | TYR469 |
| B | GLU471 |
| B | GLY516 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| A | ARG227 |
| A | GLU237 |
| A | EDO602 |
| B | ARG227 |
| B | ILE290 |
| B | HOH1064 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| A | MET242 |
| A | GLY291 |
| A | LYS292 |
| A | HOH859 |
| B | MET242 |
| B | GLY291 |
| B | LYS292 |
| B | HOH839 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 604 |
| Chain | Residue |
| B | ASN244 |
| B | ILE246 |
| B | GLY248 |
| B | TYR275 |
| B | HOH825 |
| B | HOH828 |
| B | HOH850 |
| B | HOH1001 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue LYS C 601 |
| Chain | Residue |
| C | GLY249 |
| C | ALA250 |
| C | ALA271 |
| C | GLU273 |
| C | GLU311 |
| C | TYR313 |
| C | ASN467 |
| C | TYR469 |
| C | GLU471 |
| C | GLY516 |
| C | HOH883 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 602 |
| Chain | Residue |
| C | ARG227 |
| C | ILE290 |
| C | HOH1103 |
| D | GLU237 |
| D | EDO602 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 603 |
| Chain | Residue |
| C | HIS338 |
| C | LEU528 |
| C | HOH1165 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 604 |
| Chain | Residue |
| A | ARG253 |
| C | ARG253 |
| D | ASN260 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue LYS D 601 |
| Chain | Residue |
| D | GLY249 |
| D | GLU273 |
| D | GLU311 |
| D | TYR313 |
| D | ASN467 |
| D | TYR469 |
| D | GLU471 |
| D | GLY516 |
| D | HOH994 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 602 |
| Chain | Residue |
| C | ARG227 |
| C | GLU237 |
| C | EDO602 |
| D | ARG227 |
| D | ILE290 |
| D | HOH1043 |
