5EJ9
EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0009234 | biological_process | menaquinone biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0030145 | molecular_function | manganese ion binding |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0009234 | biological_process | menaquinone biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0030145 | molecular_function | manganese ion binding |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0009234 | biological_process | menaquinone biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
C | 0030145 | molecular_function | manganese ion binding |
C | 0030976 | molecular_function | thiamine pyrophosphate binding |
C | 0042803 | molecular_function | protein homodimerization activity |
C | 0046872 | molecular_function | metal ion binding |
C | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0009234 | biological_process | menaquinone biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0030145 | molecular_function | manganese ion binding |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0042803 | molecular_function | protein homodimerization activity |
D | 0046872 | molecular_function | metal ion binding |
D | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0009234 | biological_process | menaquinone biosynthetic process |
E | 0016740 | molecular_function | transferase activity |
E | 0030145 | molecular_function | manganese ion binding |
E | 0030976 | molecular_function | thiamine pyrophosphate binding |
E | 0042803 | molecular_function | protein homodimerization activity |
E | 0046872 | molecular_function | metal ion binding |
E | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
F | 0000287 | molecular_function | magnesium ion binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0009234 | biological_process | menaquinone biosynthetic process |
F | 0016740 | molecular_function | transferase activity |
F | 0030145 | molecular_function | manganese ion binding |
F | 0030976 | molecular_function | thiamine pyrophosphate binding |
F | 0042803 | molecular_function | protein homodimerization activity |
F | 0046872 | molecular_function | metal ion binding |
F | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
G | 0000287 | molecular_function | magnesium ion binding |
G | 0003824 | molecular_function | catalytic activity |
G | 0009234 | biological_process | menaquinone biosynthetic process |
G | 0016740 | molecular_function | transferase activity |
G | 0030145 | molecular_function | manganese ion binding |
G | 0030976 | molecular_function | thiamine pyrophosphate binding |
G | 0042803 | molecular_function | protein homodimerization activity |
G | 0046872 | molecular_function | metal ion binding |
G | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
H | 0000287 | molecular_function | magnesium ion binding |
H | 0003824 | molecular_function | catalytic activity |
H | 0009234 | biological_process | menaquinone biosynthetic process |
H | 0016740 | molecular_function | transferase activity |
H | 0030145 | molecular_function | manganese ion binding |
H | 0030976 | molecular_function | thiamine pyrophosphate binding |
H | 0042803 | molecular_function | protein homodimerization activity |
H | 0046872 | molecular_function | metal ion binding |
H | 0070204 | molecular_function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | binding site for residue TPP A 601 |
Chain | Residue |
A | SER391 |
A | SER444 |
A | TYR447 |
A | ASN469 |
A | GLY471 |
A | GLY472 |
A | GLN473 |
A | ILE474 |
A | MN602 |
A | HOH757 |
A | HOH862 |
A | LEU392 |
A | HOH963 |
B | PRO30 |
B | GLU55 |
B | THR81 |
B | ALA82 |
A | SER416 |
A | GLY417 |
A | ILE418 |
A | ASP419 |
A | GLY441 |
A | ASP442 |
A | LEU443 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MN A 602 |
Chain | Residue |
A | ASP442 |
A | ASN469 |
A | GLY471 |
A | TPP601 |
A | HOH862 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue GOL A 603 |
Chain | Residue |
A | HIS49 |
A | HIS50 |
A | THR51 |
A | ARG430 |
A | LEU454 |
A | HOH723 |
A | HOH793 |
A | HOH851 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue FMT A 604 |
Chain | Residue |
A | GLY31 |
A | SER32 |
A | ARG33 |
A | THR78 |
A | ARG107 |
A | GLN118 |
A | HOH1078 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue FMT B 601 |
Chain | Residue |
B | GLY31 |
B | SER32 |
B | ARG33 |
B | THR78 |
B | ARG107 |
B | GLN118 |
B | HOH1044 |
site_id | AC6 |
Number of Residues | 24 |
Details | binding site for residue TPP B 602 |
Chain | Residue |
A | PRO30 |
A | GLU55 |
A | THR81 |
A | ALA82 |
B | SER391 |
B | LEU392 |
B | SER416 |
B | GLY417 |
B | ILE418 |
B | ASP419 |
B | GLY441 |
B | ASP442 |
B | LEU443 |
B | SER444 |
B | TYR447 |
B | ASN469 |
B | GLY471 |
B | GLY472 |
B | GLN473 |
B | ILE474 |
B | MN603 |
B | HOH767 |
B | HOH832 |
B | HOH1011 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue MN B 603 |
Chain | Residue |
B | ASP442 |
B | ASN469 |
B | GLY471 |
B | TPP602 |
B | HOH767 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue GOL B 604 |
Chain | Residue |
B | HIS49 |
B | HIS50 |
B | THR51 |
B | ARG430 |
B | LEU454 |
B | HOH750 |
B | HOH769 |
B | HOH994 |
site_id | AC9 |
Number of Residues | 25 |
Details | binding site for residue TPP C 601 |
Chain | Residue |
C | ASN469 |
C | GLY471 |
C | GLY472 |
C | GLN473 |
C | ILE474 |
C | MN602 |
C | HOH836 |
C | HOH850 |
C | HOH927 |
D | PRO30 |
D | GLU55 |
D | THR81 |
D | ALA82 |
D | HOH707 |
C | SER391 |
C | LEU392 |
C | SER416 |
C | GLY417 |
C | ILE418 |
C | ASP419 |
C | GLY441 |
C | ASP442 |
C | LEU443 |
C | SER444 |
C | TYR447 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue MN C 602 |
Chain | Residue |
C | ASP442 |
C | ASN469 |
C | GLY471 |
C | TPP601 |
C | HOH836 |
site_id | AD2 |
Number of Residues | 8 |
Details | binding site for residue GOL C 603 |
Chain | Residue |
C | HIS49 |
C | HIS50 |
C | THR51 |
C | ARG430 |
C | LEU454 |
C | HOH711 |
C | HOH728 |
D | HOH815 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue FMT C 604 |
Chain | Residue |
C | GLY31 |
C | SER32 |
C | ARG33 |
C | THR78 |
C | ARG107 |
C | GLN118 |
C | HOH996 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue FMT D 601 |
Chain | Residue |
D | GLY31 |
D | SER32 |
D | ARG33 |
D | THR78 |
D | ARG107 |
D | GLN118 |
D | HOH977 |
site_id | AD5 |
Number of Residues | 23 |
Details | binding site for residue TPP D 602 |
Chain | Residue |
C | PRO30 |
C | GLU55 |
C | THR81 |
C | ALA82 |
D | SER391 |
D | LEU392 |
D | SER416 |
D | GLY417 |
D | ILE418 |
D | ASP419 |
D | GLY441 |
D | ASP442 |
D | LEU443 |
D | SER444 |
D | ASN469 |
D | GLY471 |
D | GLY472 |
D | GLN473 |
D | ILE474 |
D | MN603 |
D | HOH820 |
D | HOH832 |
D | HOH904 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue MN D 603 |
Chain | Residue |
D | ASP442 |
D | ASN469 |
D | GLY471 |
D | TPP602 |
D | HOH820 |
site_id | AD7 |
Number of Residues | 8 |
Details | binding site for residue GOL D 604 |
Chain | Residue |
D | HIS49 |
D | HIS50 |
D | THR51 |
D | ARG430 |
D | LEU454 |
D | HOH735 |
D | HOH739 |
D | HOH766 |
site_id | AD8 |
Number of Residues | 25 |
Details | binding site for residue TPP E 601 |
Chain | Residue |
E | SER391 |
E | LEU392 |
E | SER416 |
E | GLY417 |
E | ILE418 |
E | ASP419 |
E | GLY441 |
E | ASP442 |
E | LEU443 |
E | SER444 |
E | TYR447 |
E | ASN469 |
E | GLY471 |
E | GLY472 |
E | GLN473 |
E | ILE474 |
E | MN602 |
E | HOH755 |
E | HOH831 |
E | HOH1021 |
F | PRO30 |
F | GLU55 |
F | THR81 |
F | ALA82 |
F | HOH703 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue MN E 602 |
Chain | Residue |
E | ASP442 |
E | ASN469 |
E | GLY471 |
E | TPP601 |
E | HOH831 |
site_id | AE1 |
Number of Residues | 9 |
Details | binding site for residue GOL E 603 |
Chain | Residue |
E | HIS49 |
E | HIS50 |
E | THR51 |
E | ARG430 |
E | LEU454 |
E | GLN457 |
E | HOH722 |
E | HOH775 |
E | HOH950 |
site_id | AE2 |
Number of Residues | 8 |
Details | binding site for residue FMT E 604 |
Chain | Residue |
E | GLY31 |
E | SER32 |
E | ARG33 |
E | THR78 |
E | ARG107 |
E | GLN118 |
E | HOH959 |
E | HOH1060 |
site_id | AE3 |
Number of Residues | 7 |
Details | binding site for residue FMT F 601 |
Chain | Residue |
F | GLY31 |
F | SER32 |
F | ARG33 |
F | THR78 |
F | ARG107 |
F | GLN118 |
F | HOH1045 |
site_id | AE4 |
Number of Residues | 22 |
Details | binding site for residue TPP F 602 |
Chain | Residue |
E | PRO30 |
E | GLU55 |
E | THR81 |
F | SER391 |
F | LEU392 |
F | SER416 |
F | GLY417 |
F | ILE418 |
F | ASP419 |
F | GLY441 |
F | ASP442 |
F | LEU443 |
F | SER444 |
F | ASN469 |
F | GLY471 |
F | GLY472 |
F | GLN473 |
F | ILE474 |
F | MN603 |
F | HOH783 |
F | HOH824 |
F | HOH993 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue MN F 603 |
Chain | Residue |
F | ASP442 |
F | ASN469 |
F | GLY471 |
F | TPP602 |
F | HOH824 |
site_id | AE6 |
Number of Residues | 9 |
Details | binding site for residue GOL F 604 |
Chain | Residue |
E | HOH910 |
F | HIS49 |
F | HIS50 |
F | THR51 |
F | ARG430 |
F | LEU454 |
F | GLN457 |
F | HOH806 |
F | HOH817 |
site_id | AE7 |
Number of Residues | 23 |
Details | binding site for residue TPP G 601 |
Chain | Residue |
G | SER391 |
G | LEU392 |
G | SER416 |
G | GLY417 |
G | ILE418 |
G | ASP419 |
G | GLY441 |
G | ASP442 |
G | LEU443 |
G | SER444 |
G | ASN469 |
G | GLY471 |
G | GLY472 |
G | GLN473 |
G | ILE474 |
G | MN602 |
G | HOH765 |
G | HOH809 |
G | HOH975 |
H | PRO30 |
H | GLU55 |
H | THR81 |
H | ALA82 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue MN G 602 |
Chain | Residue |
G | ASP442 |
G | ASN469 |
G | GLY471 |
G | TPP601 |
G | HOH765 |
site_id | AE9 |
Number of Residues | 9 |
Details | binding site for residue GOL G 603 |
Chain | Residue |
G | HIS49 |
G | HIS50 |
G | THR51 |
G | ARG430 |
G | LEU454 |
G | GLN457 |
G | HOH738 |
G | HOH740 |
G | HOH1052 |
site_id | AF1 |
Number of Residues | 8 |
Details | binding site for residue FMT G 604 |
Chain | Residue |
G | GLY31 |
G | SER32 |
G | ARG33 |
G | THR78 |
G | ARG107 |
G | GLN118 |
G | HOH1043 |
G | HOH1118 |
site_id | AF2 |
Number of Residues | 8 |
Details | binding site for residue FMT H 601 |
Chain | Residue |
H | GLY31 |
H | SER32 |
H | ARG33 |
H | THR78 |
H | ARG107 |
H | GLN118 |
H | HOH719 |
H | HOH859 |
site_id | AF3 |
Number of Residues | 24 |
Details | binding site for residue TPP H 602 |
Chain | Residue |
G | PRO30 |
G | GLU55 |
G | THR81 |
G | ALA82 |
H | SER391 |
H | LEU392 |
H | SER416 |
H | GLY417 |
H | ILE418 |
H | ASP419 |
H | GLY441 |
H | ASP442 |
H | LEU443 |
H | SER444 |
H | TYR447 |
H | ASN469 |
H | GLY471 |
H | GLY472 |
H | GLN473 |
H | ILE474 |
H | MN603 |
H | HOH834 |
H | HOH897 |
H | HOH1015 |
site_id | AF4 |
Number of Residues | 5 |
Details | binding site for residue MN H 603 |
Chain | Residue |
H | ASP442 |
H | ASN469 |
H | GLY471 |
H | TPP602 |
H | HOH834 |
site_id | AF5 |
Number of Residues | 9 |
Details | binding site for residue GOL H 604 |
Chain | Residue |
H | HIS49 |
H | HIS50 |
H | THR51 |
H | ARG430 |
H | LEU454 |
H | GLN457 |
H | HOH725 |
H | HOH789 |
H | HOH792 |