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5EIR

Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000339molecular_functionRNA cap binding
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000932cellular_componentP-body
A0001662biological_processbehavioral fear response
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006406biological_processmRNA export from nucleus
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0006417biological_processregulation of translation
A0010494cellular_componentcytoplasmic stress granule
A0010507biological_processnegative regulation of autophagy
A0016281cellular_componenteukaryotic translation initiation factor 4F complex
A0016442cellular_componentRISC complex
A0016604cellular_componentnuclear body
A0016607cellular_componentnuclear speck
A0017148biological_processnegative regulation of translation
A0019827biological_processstem cell population maintenance
A0019899molecular_functionenzyme binding
A0030182biological_processneuron differentiation
A0031370molecular_functioneukaryotic initiation factor 4G binding
A0033391cellular_componentchromatoid body
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0045665biological_processnegative regulation of neuron differentiation
A0045931biological_processpositive regulation of mitotic cell cycle
A0048471cellular_componentperinuclear region of cytoplasm
A0051028biological_processmRNA transport
A0051168biological_processnuclear export
A0070062cellular_componentextracellular exosome
A0071549biological_processcellular response to dexamethasone stimulus
A0098794cellular_componentpostsynapse
A0098808molecular_functionmRNA cap binding
A0098978cellular_componentglutamatergic synapse
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residues 5O8 A 301 and SO4 A 302
ChainResidue
ATRP56
AALA204
AHOH413
AHOH416
AMET101
ATRP102
AGLU103
AARG112
AARG157
ATRP166
AHIS200
ATHR203

site_idAC2
Number of Residues12
Detailsbinding site for residues 5O8 A 301 and SO4 A 302
ChainResidue
ATRP56
AMET101
ATRP102
AGLU103
AARG112
AARG157
ATRP166
AHIS200
ATHR203
AALA204
AHOH413
AHOH416

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11879179, ECO:0000269|PubMed:12975586, ECO:0000269|PubMed:16271312
ChainResidueDetails
ATRP56
ATRP102
AARG157
ATHR205

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: (Microbial infection) Interaction with potato virus Y VPg => ECO:0000269|PubMed:31712417
ChainResidueDetails
ALYS159

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR22

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:25923732, ECO:0000269|PubMed:7665584, ECO:0000269|PubMed:7782323
ChainResidueDetails
ASER209

229183

PDB entries from 2024-12-18

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