5EG2

SET7/9 N265A in complex with AdoHcy and TAF10 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005694	cellular_component	chromosome
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0140945	molecular_function	histone H3K4 monomethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue SAH A 401

Chain	Residue
A	ALA226
A	GLU356
A	HOH515
A	HOH518
A	HOH584
A	HOH642
A	HOH653
A	HOH662
A	HOH695
B	MLZ189
A	GLU228
A	GLY264
A	HIS293
A	LYS294
A	ASN296
A	HIS297
A	TYR335
A	TRP352

---

site_id	AC2
Number of Residues	7
Details	binding site for residue NA A 402

Chain	Residue
A	TYR122
A	GLY126
A	GLY127
A	SER128
A	VAL147
A	TYR148
A	HOH607

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6,N6,N6-trimethyllysine; alternate => ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:16415881, ECO:0000269|PubMed:25959397

Chain	Residue	Details
A	HIS297
A	ASN296
B	MLZ189

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	GLU356

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	SITE: Histone H3K4 binding => ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	TYR245
A	ASP256
A	THR266
A	LYS317
A	TYR335

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 350

Chain	Residue	Details
A	TYR245	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	HIS293	electrostatic stabiliser, hydrogen bond acceptor
A	HIS297	electrostatic stabiliser, hydrogen bond acceptor
A	TYR305	activator, electrostatic stabiliser, hydrogen bond acceptor
A	TYR335	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

---