5EAN
Crystal structure of Dna2 in complex with a 5' overhang DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000076 | biological_process | DNA replication checkpoint signaling |
| A | 0000723 | biological_process | telomere maintenance |
| A | 0000729 | biological_process | DNA double-strand break processing |
| A | 0000781 | cellular_component | chromosome, telomeric region |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003678 | molecular_function | DNA helicase activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005760 | cellular_component | gamma DNA polymerase complex |
| A | 0006260 | biological_process | DNA replication |
| A | 0006264 | biological_process | mitochondrial DNA replication |
| A | 0006284 | biological_process | base-excision repair |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0017108 | molecular_function | 5'-flap endonuclease activity |
| A | 0017116 | molecular_function | single-stranded DNA helicase activity |
| A | 0032201 | biological_process | telomere maintenance via semi-conservative replication |
| A | 0033567 | biological_process | DNA replication, Okazaki fragment processing |
| A | 0033892 | molecular_function | deoxyribonuclease (pyrimidine dimer) activity |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| A | 0043137 | biological_process | DNA replication, removal of RNA primer |
| A | 0043139 | molecular_function | 5'-3' DNA helicase activity |
| A | 0043504 | biological_process | mitochondrial DNA repair |
| A | 0045740 | biological_process | positive regulation of DNA replication |
| A | 0071932 | biological_process | replication fork reversal |
| A | 1902990 | biological_process | mitotic telomere maintenance via semi-conservative replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SF4 A 1101 |
| Chain | Residue |
| A | CYS137 |
| A | ARG140 |
| A | CYS394 |
| A | CYS397 |
| A | CYS403 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 1102 |
| Chain | Residue |
| B | DA12 |
| B | HOH201 |
| A | HIS164 |
| A | ASP278 |
| A | GLU299 |
| A | LEU300 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue ADP A 1103 |
| Chain | Residue |
| A | GLY626 |
| A | LEU627 |
| A | ASN628 |
| A | GLN631 |
| A | GLY654 |
| A | THR656 |
| A | THR657 |
| A | LYS689 |
| A | TYR828 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 101 |
| Chain | Residue |
| A | LYS301 |
| A | HOH1202 |
| B | DG11 |
| B | DA12 |
| B | DG13 |
| B | HOH201 |
| B | HOH202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 198 |
| Details | Domain: {"description":"UPF1-type SF1B helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 229 |
| Details | Domain: {"description":"UPF1-type SF1B helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
