5EAF
Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Fluquinconazole
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0032259 | biological_process | methylation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016126 | biological_process | sterol biosynthetic process |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| B | 0032259 | biological_process | methylation |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue HEM A 601 |
| Chain | Residue |
| A | PHE113 |
| A | LEU374 |
| A | PRO379 |
| A | LEU383 |
| A | ARG385 |
| A | PRO462 |
| A | PHE463 |
| A | GLY464 |
| A | HIS468 |
| A | CYS470 |
| A | GLY472 |
| A | TYR126 |
| A | FQC602 |
| A | TYR140 |
| A | LEU147 |
| A | LYS151 |
| A | VAL311 |
| A | GLY315 |
| A | THR318 |
| A | THR322 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue FQC A 602 |
| Chain | Residue |
| A | TYR126 |
| A | LEU129 |
| A | THR130 |
| A | ILE139 |
| A | GLY310 |
| A | GLY314 |
| A | LEU380 |
| A | HEM601 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue HEM B 601 |
| Chain | Residue |
| B | PHE113 |
| B | TYR126 |
| B | TYR140 |
| B | LEU147 |
| B | LYS151 |
| B | VAL311 |
| B | GLY315 |
| B | THR318 |
| B | THR322 |
| B | LEU374 |
| B | PRO379 |
| B | LEU383 |
| B | ARG385 |
| B | PRO462 |
| B | PHE463 |
| B | GLY464 |
| B | HIS468 |
| B | ARG469 |
| B | CYS470 |
| B | GLY472 |
| B | FQC602 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue FQC B 602 |
| Chain | Residue |
| B | TYR126 |
| B | THR130 |
| B | PHE134 |
| B | PHE236 |
| B | PHE241 |
| B | GLY310 |
| B | GLY314 |
| B | LEU380 |
| B | HEM601 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG |
| Chain | Residue | Details |
| A | PHE463-GLY472 |
