5E9G
Structural insights of isocitrate lyases from Magnaporthe oryzae
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004451 | molecular_function | isocitrate lyase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006097 | biological_process | glyoxylate cycle |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0009514 | cellular_component | glyoxysome |
A | 0016829 | molecular_function | lyase activity |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0046421 | molecular_function | methylisocitrate lyase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004451 | molecular_function | isocitrate lyase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006097 | biological_process | glyoxylate cycle |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0009514 | cellular_component | glyoxysome |
B | 0016829 | molecular_function | lyase activity |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0046421 | molecular_function | methylisocitrate lyase activity |
B | 0046872 | molecular_function | metal ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004451 | molecular_function | isocitrate lyase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006097 | biological_process | glyoxylate cycle |
C | 0006099 | biological_process | tricarboxylic acid cycle |
C | 0009514 | cellular_component | glyoxysome |
C | 0016829 | molecular_function | lyase activity |
C | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0046421 | molecular_function | methylisocitrate lyase activity |
C | 0046872 | molecular_function | metal ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004451 | molecular_function | isocitrate lyase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006097 | biological_process | glyoxylate cycle |
D | 0006099 | biological_process | tricarboxylic acid cycle |
D | 0009514 | cellular_component | glyoxysome |
D | 0016829 | molecular_function | lyase activity |
D | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0046421 | molecular_function | methylisocitrate lyase activity |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue GLV A 601 |
Chain | Residue |
A | TYR104 |
A | MG603 |
A | SER106 |
A | GLY107 |
A | TRP108 |
A | ASP177 |
A | HIS204 |
A | ARG252 |
A | TRP403 |
A | THR467 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue GOL A 602 |
Chain | Residue |
A | TRP108 |
A | CYS215 |
A | GLY216 |
A | HIS217 |
A | ARG252 |
A | GLU405 |
A | ASN433 |
A | SER435 |
A | THR467 |
A | HOH716 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MG A 603 |
Chain | Residue |
A | ASP177 |
A | GLV601 |
A | HOH701 |
A | HOH716 |
A | HOH717 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue GLV B 601 |
Chain | Residue |
B | TYR104 |
B | SER106 |
B | GLY107 |
B | TRP108 |
B | ASP177 |
B | HIS204 |
B | ARG252 |
B | TRP403 |
B | THR467 |
B | GOL602 |
B | MG603 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue GOL B 602 |
Chain | Residue |
B | CYS215 |
B | GLY216 |
B | HIS217 |
B | ARG252 |
B | GLU405 |
B | ASN433 |
B | SER435 |
B | SER437 |
B | THR467 |
B | GLV601 |
B | HOH704 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue MG B 603 |
Chain | Residue |
B | ASP177 |
B | LYS213 |
B | GLV601 |
B | HOH702 |
B | HOH704 |
B | HOH705 |
site_id | AC7 |
Number of Residues | 11 |
Details | binding site for residue GLV C 601 |
Chain | Residue |
C | TYR104 |
C | SER106 |
C | GLY107 |
C | TRP108 |
C | ASP177 |
C | ARG252 |
C | TRP403 |
C | MG602 |
C | HOH706 |
C | HOH723 |
C | HOH728 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue MG C 602 |
Chain | Residue |
C | ASP177 |
C | GLV601 |
C | HOH706 |
C | HOH707 |
C | HOH726 |
site_id | AC9 |
Number of Residues | 11 |
Details | binding site for residue GLV D 601 |
Chain | Residue |
D | TYR104 |
D | SER106 |
D | GLY107 |
D | TRP108 |
D | ASP177 |
D | HIS204 |
D | ARG252 |
D | TRP403 |
D | THR467 |
D | GOL602 |
D | MG603 |
site_id | AD1 |
Number of Residues | 10 |
Details | binding site for residue GOL D 602 |
Chain | Residue |
D | CYS215 |
D | GLY216 |
D | HIS217 |
D | ARG252 |
D | GLU405 |
D | ASN433 |
D | SER435 |
D | SER437 |
D | GLV601 |
D | HOH703 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue MG D 603 |
Chain | Residue |
D | ASP177 |
D | GLV601 |
D | HOH703 |
D | HOH709 |
D | HOH710 |
Functional Information from PROSITE/UniProt
site_id | PS00161 |
Number of Residues | 6 |
Details | ISOCITRATE_LYASE Isocitrate lyase signature. KKCGHM |
Chain | Residue | Details |
A | LYS213-MET218 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 |
Chain | Residue | Details |
A | CYS215 | |
B | CYS215 | |
C | CYS215 | |
D | CYS215 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P9WKK7 |
Chain | Residue | Details |
A | SER106 | |
B | ARG252 | |
B | ASN433 | |
B | THR467 | |
C | SER106 | |
C | ASP177 | |
C | GLY216 | |
C | ARG252 | |
C | ASN433 | |
C | THR467 | |
D | SER106 | |
A | ASP177 | |
D | ASP177 | |
D | GLY216 | |
D | ARG252 | |
D | ASN433 | |
D | THR467 | |
A | GLY216 | |
A | ARG252 | |
A | ASN433 | |
A | THR467 | |
B | SER106 | |
B | ASP177 | |
B | GLY216 |