5E7Y
Crystal structure of P450 BM3 heme domain M7 variant
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0020037 | molecular_function | heme binding |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | binding site for residue HEM A 501 |
Chain | Residue |
A | LYS69 |
A | PHE331 |
A | PRO392 |
A | PHE393 |
A | GLY394 |
A | ARG398 |
A | ALA399 |
A | CYS400 |
A | ILE401 |
A | GLY402 |
A | HOH602 |
A | LEU86 |
A | HOH604 |
A | HOH618 |
A | HOH637 |
A | HOH644 |
A | HOH665 |
A | ALA87 |
A | TRP96 |
A | ALA264 |
A | GLY265 |
A | THR268 |
A | THR269 |
A | THR327 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue GOL A 502 |
Chain | Residue |
A | ALA264 |
A | HOH602 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | ARG132 |
A | GOL506 |
B | ASP121 |
B | VAL124 |
B | HOH615 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | LYS41 |
A | ARG50 |
A | HOH624 |
A | HOH682 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | LYS391 |
A | GLY394 |
A | ASN395 |
A | GLY396 |
A | GLN403 |
A | HOH639 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | GLN128 |
A | ARG132 |
A | GOL503 |
B | ASP121 |
B | ARG161 |
site_id | AC7 |
Number of Residues | 26 |
Details | binding site for residue HEM B 501 |
Chain | Residue |
B | LYS69 |
B | LEU86 |
B | ALA87 |
B | TRP96 |
B | ALA264 |
B | GLY265 |
B | THR268 |
B | THR269 |
B | THR327 |
B | PHE331 |
B | PRO392 |
B | PHE393 |
B | GLY394 |
B | ARG398 |
B | ALA399 |
B | CYS400 |
B | ILE401 |
B | GLY402 |
B | ALA406 |
B | GOL502 |
B | HOH607 |
B | HOH635 |
B | HOH644 |
B | HOH648 |
B | HOH658 |
B | HOH701 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue GOL B 502 |
Chain | Residue |
B | ALA328 |
B | LEU437 |
B | HEM501 |
B | HOH635 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
B | TRP130 |
B | LEU133 |
B | ASN134 |
B | ALA448 |
B | SER450 |
B | HOH737 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue GOL B 504 |
Chain | Residue |
B | LYS391 |
B | GLY394 |
B | ASN395 |
B | GLY396 |
B | GLN403 |
B | HOH728 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGnGQRACIG |
Chain | Residue | Details |
A | PHE393-GLY402 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15020590, ECO:0007744|PDB:1SMJ |
Chain | Residue | Details |
A | TYR51 | |
B | TYR51 |
Chain | Residue | Details |
A | CYS400 | |
B | CYS400 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Important for catalytic activity => ECO:0000305|PubMed:16403573, ECO:0000305|PubMed:7578081 |
Chain | Residue | Details |
A | THR268 | |
B | THR268 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
A | THR268 | electrostatic stabiliser, steric role |
A | PHE393 | electrostatic stabiliser, steric role |
A | CYS400 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
B | THR268 | electrostatic stabiliser, steric role |
B | PHE393 | electrostatic stabiliser, steric role |
B | CYS400 | electrostatic stabiliser |