5E6U
Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand
Functional Information from GO Data
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| B | SER114 | |
| A | ASP569 | |
| A | ASP573 | |
| B | SER116 | |
| B | GLU212 | |
| A | GLU451 | |
| A | ASP505 | |
| A | ASN507 | |
| A | ASP509 | |
| A | ASP513 | |
| A | ASP565 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72 |
| Chain | Residue | Details |
| B | ASP119 | |
| A | ASN64 | |
| A | ASN624 | |
| A | ARG645 | |
| A | ARG701 | |
| A | ASN705 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| B | ASP120 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| B | ASP151 | |
| B | ASN207 | |
| B | ASP209 | |
| B | PRO211 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| B | ASP242 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH |
| Chain | Residue | Details |
| B | GLU325 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816 |
| Chain | Residue | Details |
| B | GLN1 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| B | ASN28 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN |
| Chain | Residue | Details |
| B | ASN94 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| B | ASN190 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | LYS232 |
